STRINGSTRING
AJC44591.1 AJC44591.1 AJC47416.1 AJC47416.1 AJC44425.1 AJC44425.1 AJC44546.1 AJC44546.1 AJC47431.1 AJC47431.1 dapA dapA panD panD AJC44588.1 AJC44588.1 thrB thrB mtnC mtnC mtnD mtnD mtnB mtnB AJC44611.1 AJC44611.1 carA carA carB carB AJC47468.1 AJC47468.1 folD folD AJC47470.1 AJC47470.1 pheA pheA serC serC mtnA mtnA AJC44949.1 AJC44949.1 AJC44979.1 AJC44979.1 AJC45151.1 AJC45151.1 AJC45153.1 AJC45153.1 asnB asnB dapD dapD AJC45258.1 AJC45258.1 trpA trpA trpB trpB trpF trpF asd asd AJC45399.1 AJC45399.1 AJC45434.1 AJC45434.1 AJC45462.1 AJC45462.1 AJC45517.1 AJC45517.1 AJC45592.1 AJC45592.1 AJC45683.1 AJC45683.1 AJC45792.1 AJC45792.1 AJC47556.1 AJC47556.1 metF metF glyA glyA AJC46015.1 AJC46015.1 AJC46032.1 AJC46032.1 alr alr trpC trpC trpE trpE metE metE gltB gltB glnA glnA AJC46768.1 AJC46768.1 AJC46782.1 AJC46782.1 ilvD ilvD AJC46854.1 AJC46854.1 AJC46858.1 AJC46858.1 AJC47071.1 AJC47071.1 dapF dapF leuB leuB leuD leuD leuA leuA AJC47247.1 AJC47247.1 AJC47248.1 AJC47248.1 ilvC ilvC argD argD cysK cysK cysI cysI AJC47377.1 AJC47377.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJC44591.1Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
AJC47416.1Histone acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
AJC44425.1Diaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
AJC44546.1Catalyzes the formation of O-acetyl -L-homoserine from L-homoserine and acetyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the AB hydrolase superfamily. MetX family. (345 aa)
AJC47431.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (357 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (302 aa)
panDAspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa)
AJC44588.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the homoserine dehydrogenase family. (841 aa)
thrBSerine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (322 aa)
mtnCHaloacid dehalogenase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (232 aa)
mtnDAcireductone dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (188 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (213 aa)
AJC44611.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (413 aa)
carACarbamoyl-phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (374 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1080 aa)
AJC47468.1GCN5 family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (303 aa)
AJC47470.1GNAT family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
pheAPrephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
serCMFS transporter; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
mtnAMethylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (354 aa)
AJC44949.15-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (920 aa)
AJC44979.1Prephenate dehydrogenase; Catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
AJC45151.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (460 aa)
AJC45153.1Gamma-glutamylputrescine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (459 aa)
asnBFunctions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; Derived by automated computational analysis using gene prediction method: Protein Homology. (563 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transferase hexapeptide repeat family. (331 aa)
AJC45258.1Lysine 6-aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (498 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (267 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (405 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (220 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa)
AJC45399.1Homocysteine methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (314 aa)
AJC45434.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (81 aa)
AJC45462.15'-methylthioadenosine phosphorylase; Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. (248 aa)
AJC45517.1Dihydroxy-acid dehydratase; Catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (574 aa)
AJC45592.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
AJC45683.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
AJC45792.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
AJC47556.1Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (168 aa)
metF5,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (280 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
AJC46015.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
AJC46032.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (357 aa)
trpCIndole-3-glycerol-phosphate synthase; Involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (265 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (491 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (763 aa)
gltBCatalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (1485 aa)
glnAForms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
AJC46768.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
AJC46782.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (102 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (612 aa)
AJC46854.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
AJC46858.1Integrase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1064 aa)
AJC47071.1Pyruvate dehydrogenase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (574 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (353 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (192 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (518 aa)
AJC47247.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
AJC47248.1Acetolactate synthase catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (335 aa)
argDAcetylornithine aminotransferase; Catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (410 aa)
cysKCysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (319 aa)
cysISulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (574 aa)
AJC47377.1NADP oxidoreductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (623 aa)
Your Current Organism:
Xanthomonas sacchari
NCBI taxonomy Id: 56458
Other names: CFBP 4641, ICMP 16916, LMG 471, LMG:471, X. sacchari
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.