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| | cmk | Cytidylate kinase. (179 aa) |
| | egsA | Glycerol-1-phosphate dehydrogenase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea. Belongs to the glycerol-1-phosphate dehydrogenase family. (351 aa) |
| | GACE_2182 | Butyryl-CoA dehydrogenase. (415 aa) |
| | GACE_2180 | Decarboxylase. (452 aa) |
| | GACE_2173 | Pimeloyl-CoA dehydrogenase, small subunit PimD. (383 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (220 aa) |
| | GACE_2153 | 2-ketoisovalerate ferredoxin oxidoreductase, fused subunits gamma and delta. (296 aa) |
| | GACE_2145 | Phosphorybosyl pyrophosphate synthase. (279 aa) |
| | GACE_2118 | Pimeloyl-CoA dehydrogenase, large subunit PimC. (397 aa) |
| | GACE_2076 | Rhodanese-like domain protein. (131 aa) |
| | GACE_2065 | Bifunctional sugar nucleotidyltransferase/CDP-alcohol phosphatidyltransferase synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (407 aa) |
| | GACE_2052 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (290 aa) |
| | GACE_2045 | Hypothetical protein. (123 aa) |
| | purP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (359 aa) |
| | cofC | 2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (200 aa) |
| | mptA | GTP cyclohydrolase; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin. (305 aa) |
| | GACE_2008 | Hypothetical protein. (454 aa) |
| | GACE_2007 | Molybdopterin biosynthesis protein MoeA. (535 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (277 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (760 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (90 aa) |
| | GACE_1990 | acetyl-CoA synthetase. (678 aa) |
| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (311 aa) |
| | GACE_1955 | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. (375 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (478 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (169 aa) |
| | GACE_1916 | Phosphoglycerate mutase. (380 aa) |
| | prs | Phosphorybosyl pyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (277 aa) |
| | GACE_1907 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (128 aa) |
| | GACE_1896 | Methanogenesis marker protein 2. (315 aa) |
| | GACE_1884 | Pantoate kinase, archaeal. (270 aa) |
| | GACE_1883 | Phosphopantothenoylcysteine decarboxylase. (400 aa) |
| | GACE_1860 | Hydroxymethylglutaryl-CoA reductase. (420 aa) |
| | GACE_1830 | Xanthosine/inosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (179 aa) |
| | GACE_1811 | Hypothetical protein. (174 aa) |
| | GACE_1787 | Molybdopterin-guanine dinucleotide biosynthesis protein MobB. (167 aa) |
| | pyrB | Aspartate carbamoyltransferase. (297 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain (PyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | GACE_1765 | Orotate phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (196 aa) |
| | GACE_1739 | Molybdenum cofactor biosynthesis protein MoaD. (78 aa) |
| | GACE_1738 | Molybdopterin biosynthesis protein MoeA. (388 aa) |
| | atpE | V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (183 aa) |
| | atpC | V-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (347 aa) |
| | atpF | V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (101 aa) |
| | atpA | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (578 aa) |
| | atpB | V-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (209 aa) |
| | GACE_1720 | Bifunctional acetyl-CoA decarbonylase/synthase complex subunit. (385 aa) |
| | GACE_1691 | Butyryl-CoA dehydrogenase. (390 aa) |
| | GACE_1690 | HIT family hydrolase. (163 aa) |
| | GACE_1685 | Adenylate cyclase. (175 aa) |
| | GACE_1680 | Flavoprotein. (190 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (372 aa) |
| | mobA | Molybdopterin-guanine dinucleotide biosynthesis protein MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor. (205 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family. (294 aa) |
| | GACE_1675 | Hypothetical protein. (52 aa) |
| | GACE_1673 | AMP/CMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (176 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (400 aa) |
| | carS | Phosphatidate cytidylyltransferase; Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn- glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1- phosphate (DGGGP) and CTP. This reaction is the third ether-bond- formation step in the biosynthesis of archaeal membrane lipids. (179 aa) |
| | GACE_1585 | Nicotinamide-nucleotide adenylyltransferase, NadM family. (171 aa) |
| | GACE_1576 | UbiA prenyltransferase. (280 aa) |
| | GACE_1575 | (S)-3-O-geranylgeranylglyceryl phosphate synthase; Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. (228 aa) |
| | GACE_1557 | acetyl-CoA synthetase. (646 aa) |
| | guaAA | GMP synthase [glutamine-hydrolyzing], amidotransferase subunit; Catalyzes the synthesis of GMP from XMP. (184 aa) |
| | surE | 5-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (222 aa) |
| | mptD | Hypothetical protein; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family. (108 aa) |
| | cofE | F420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (252 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (142 aa) |
| | GACE_1473 | Uncharacterized protein, contains DUF137 domain. (238 aa) |
| | GACE_1421 | Phosphohydrolase. (383 aa) |
| | nadK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (258 aa) |
| | GACE_1418 | Inositol-1-monophosphatase. (255 aa) |
| | GACE_1415 | Pyruvate ferredoxin oxidoreductase, delta subunit. (97 aa) |
| | GACE_1414 | Pyruvate ferredoxin oxidoreductase, gamma subunit. (189 aa) |
| | GACE_1413 | Glutaryl-CoA dehydrogenase. (398 aa) |
| | GACE_1369 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (452 aa) |
| | GACE_1368 | Thiamin biosynthesis protein ThiC. (426 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (456 aa) |
| | GACE_1337 | Hypothetical protein; Catalyzes the addition of 3 molecules of isopentenyl diphosphate (IPP) onto dimethylallyl diphosphate (DMAPP) to form geranylgeranyl pyrophosphate (GGPP). Catalyzes the synthesis of geranylgeranyl pyrophosphate as a major product and of farnesyl pyrophosphate in smaller amounts. (319 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa) |
| | GACE_1323 | BioD-like N-terminal domain of phosphotransacetylase. (354 aa) |
| | GACE_1320 | Molybdenum cofactor biosynthesis protein MoaB. (169 aa) |
| | GACE_1317 | Nucleoside triphosphatase; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (169 aa) |
| | GACE_1310 | Butyryl-CoA dehydrogenase. (364 aa) |
| | mvk | Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (293 aa) |
| | GACE_1242 | Hypothetical protein. (292 aa) |
| | mptE | Hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (200 aa) |
| | GACE_1206 | Molybdenum cofactor biosynthesis protein MoaE. (235 aa) |
| | GACE_1196 | Rhodanese-like domain protein. (132 aa) |
| | GACE_1179 | Inositol-1-phosphate synthase. (392 aa) |
| | cofD | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (297 aa) |
| | GACE_1100 | Molybdopterin biosynthesis protein. (89 aa) |
| | thiI | Thiamine biosynthesis ATP pyrophosphatase; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (376 aa) |
| | guaAB | GMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (304 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (412 aa) |
| | tmk | Thymidylate kinase. (220 aa) |
| | GACE_1040 | Molybdopterin binding motif, CinA N-terminal domain. (224 aa) |
| | GACE_1026 | MazG-related protein. (92 aa) |
| | GACE_0958 | Hypothetical protein. (287 aa) |
| | GACE_0951 | Phosphatidylserine decarboxylase. (188 aa) |
| | GACE_0950 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (191 aa) |
| | GACE_0921 | acetyl-CoA synthetase. (631 aa) |
| | GACE_0913 | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (188 aa) |
| | GACE_0822 | Dehydrogenase (flavoprotein)-like protein. (322 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (212 aa) |
| | GACE_0770 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa) |
| | GACE_0765 | Cyclohex-1-ene-1-carboxyl-CoA hydratase, BadK; Belongs to the enoyl-CoA hydratase/isomerase family. (659 aa) |
| | GACE_0764 | Indoleyruvate:ferredoxin oxidoreductase beta subunit. (186 aa) |
| | pyrD | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (298 aa) |
| | GACE_0751 | Methylmalonyl-CoA epimerase. (134 aa) |
| | GACE_0732 | Inosine/xanthosine triphosphatase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (174 aa) |
| | GACE_0724 | Butyryl-CoA dehydrogenase. (382 aa) |
| | GACE_0698 | Pyruvate ferredoxin oxidoreductase, gamma subunit. (162 aa) |
| | GACE_0697 | Pyruvate ferredoxin oxidoreductase, delta subunit. (83 aa) |
| | nnrE | Carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epim [...] (467 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (231 aa) |
| | GACE_0595 | Geranylgeranyl diphosphate reductase. (368 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (167 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (156 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (341 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (360 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1076 aa) |
| | GACE_0555 | 1-(5-Phosphoribosyl)-5-amino-4-imidazole- carboxylate(AIR) carboxylase. (243 aa) |
| | GACE_0546 | Uridine kinase. (307 aa) |
| | GACE_0529 | Molybdenum cofactor biosynthesis protein MoaD. (88 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase NAD(P)-dependent, phosphorylating. (335 aa) |
| | GACE_0471 | Butyryl-CoA dehydrogenase. (434 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | GACE_0401 | Uridine monophosphate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (219 aa) |
| | ribL | FAD synthase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (148 aa) |
| | apgM | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (416 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (258 aa) |
| | GACE_0363 | Glucose-6-phosphate isomerase. (236 aa) |
| | cdhA | CO dehydrogenase/acetyl-CoA synthase subunit alpha; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (803 aa) |
| | cdhC | CO dehydrogenase/acetyl-CoA synthase subunit beta; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (521 aa) |
| | cdhE | CO dehydrogenase/acetyl-CoA synthase subunit gamma; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (472 aa) |
| | GACE_0306 | Xanthine-guanine phosphoribosyltransferase. (233 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (232 aa) |
| | GACE_0280 | Phosphopantetheine adenylyltransferase. (151 aa) |
| | pdxS | Pyridoxine biosynthesis glutamine amidotransferase, synthase subunit; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (333 aa) |
| | pdxT | Pyridoxine biosynthesis glutamine amidotransferase, glutaminase subunit; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (195 aa) |
| | GACE_0249 | Thymidylate synthase. (426 aa) |
| | GACE_0217 | Dihydroorotase. (404 aa) |
| | hpt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (186 aa) |
| | GACE_0172 | acetyl-CoA synthetase. (587 aa) |
| | GACE_0161 | Hypothetical protein. (95 aa) |
| | GACE_0160 | Nicotinate phosphoribosyltransferase. (380 aa) |
| | rbcL | Ribulose bisophosphate carboxylase (large subunit); Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (444 aa) |
| | GACE_0152 | Formate dehydrogenase family accessory protein FdhD. (222 aa) |
| | thi4 | Thiazole biosynthetic enzyme; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. (257 aa) |
| | GACE_0140 | Indoleyruvate:ferredoxin oxidoreductase beta subunit. (198 aa) |
| | GACE_0138 | Protein containing rhodanese-like domain. (140 aa) |
| | GACE_0136 | Butyryl-CoA dehydrogenase. (378 aa) |
| | GACE_0123 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. (505 aa) |
| | GACE_0121 | dCMP deaminase. (152 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (326 aa) |
| | GACE_0072 | Geranylgeranyl reductase; Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3- diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di- O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. (390 aa) |
| | ribK | Riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (214 aa) |
