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| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (212 aa) |
| | GACE_0160 | Nicotinate phosphoribosyltransferase. (380 aa) |
| | GACE_0172 | acetyl-CoA synthetase. (587 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (262 aa) |
| | hpt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. (186 aa) |
| | GACE_0217 | Dihydroorotase. (404 aa) |
| | GACE_0249 | Thymidylate synthase. (426 aa) |
| | GACE_0280 | Phosphopantetheine adenylyltransferase. (151 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (232 aa) |
| | GACE_0306 | Xanthine-guanine phosphoribosyltransferase. (233 aa) |
| | mtnP | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (282 aa) |
| | nadE | NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (258 aa) |
| | polB | Archaeal DNA polymerase II small subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase; Belongs to the DNA polymerase delta/II small subunit family. (491 aa) |
| | ribL | FAD synthase; Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme. (148 aa) |
| | GACE_0401 | Uridine monophosphate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (219 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | GACE_0413 | DNA polymerase III epsilon subunit. (206 aa) |
| | GACE_0471 | Butyryl-CoA dehydrogenase. (434 aa) |
| | priS | DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...] (357 aa) |
| | GACE_0546 | Uridine kinase. (307 aa) |
| | GACE_0555 | 1-(5-Phosphoribosyl)-5-amino-4-imidazole- carboxylate(AIR) carboxylase. (243 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1076 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (360 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (341 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (156 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (167 aa) |
| | GACE_0607 | Transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (229 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). (231 aa) |
| | GACE_0697 | Pyruvate ferredoxin oxidoreductase, delta subunit. (83 aa) |
| | GACE_0698 | Pyruvate ferredoxin oxidoreductase, gamma subunit. (162 aa) |
| | GACE_0724 | Butyryl-CoA dehydrogenase. (382 aa) |
| | GACE_0743 | Archaeal DNA polymerase I. (781 aa) |
| | pyrD | Dihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (298 aa) |
| | GACE_0764 | Indoleyruvate:ferredoxin oxidoreductase beta subunit. (186 aa) |
| | GACE_0770 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa) |
| | tbp | TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (183 aa) |
| | GACE_0913 | Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (188 aa) |
| | GACE_0915 | DNA-directed RNA polymerase subunit E'. (188 aa) |
| | GACE_0921 | acetyl-CoA synthetase. (631 aa) |
| | GACE_0955 | Transcription-associated protein TFIIS; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (103 aa) |
| | GACE_1040 | Molybdopterin binding motif, CinA N-terminal domain. (224 aa) |
| | tmk | Thymidylate kinase. (220 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (337 aa) |
| | priL | DNA primase large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (387 aa) |
| | cmk | Cytidylate kinase. (179 aa) |
| | GACE_2182 | Butyryl-CoA dehydrogenase. (415 aa) |
| | GACE_2180 | Decarboxylase. (452 aa) |
| | GACE_2173 | Pimeloyl-CoA dehydrogenase, small subunit PimD. (383 aa) |
| | GACE_2153 | 2-ketoisovalerate ferredoxin oxidoreductase, fused subunits gamma and delta. (296 aa) |
| | GACE_2145 | Phosphorybosyl pyrophosphate synthase. (279 aa) |
| | GACE_2118 | Pimeloyl-CoA dehydrogenase, large subunit PimC. (397 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (412 aa) |
| | GACE_2052 | 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (290 aa) |
| | polC | Archaeal DNA polymerase II large subunit; Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. (1134 aa) |
| | purP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. (359 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ a [...] (277 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase, synthetase subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is t [...] (760 aa) |
| | purS | Phosphoribosylformylglycinamidine synthase, PurS subunit; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (90 aa) |
| | GACE_1991 | Hypothetical protein. (119 aa) |
| | GACE_1990 | acetyl-CoA synthetase. (678 aa) |
| | GACE_1955 | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. (375 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (478 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (169 aa) |
| | prs | Phosphorybosyl pyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (277 aa) |
| | GACE_1896 | Methanogenesis marker protein 2. (315 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (452 aa) |
| | tfe | Archaeal transcription factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexe [...] (172 aa) |
| | GACE_1884 | Pantoate kinase, archaeal. (270 aa) |
| | GACE_1883 | Phosphopantothenoylcysteine decarboxylase. (400 aa) |
| | pyrB | Aspartate carbamoyltransferase. (297 aa) |
| | pyrI | Aspartate carbamoyltransferase regulatory chain (PyrI); Involved in allosteric regulation of aspartate carbamoyltransferase. (152 aa) |
| | GACE_1765 | Orotate phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (196 aa) |
| | GACE_1744 | Archaeal histone. (67 aa) |
| | atpE | V-type ATP synthase subunit E; Produces ATP from ADP in the presence of a proton gradient across the membrane. (183 aa) |
| | atpC | V-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. (347 aa) |
| | atpF | V-type ATP synthase subunit F; Produces ATP from ADP in the presence of a proton gradient across the membrane. (101 aa) |
| | atpA | V-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (578 aa) |
| | atpB | V-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (463 aa) |
| | atpD | V-type ATP synthase subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. (209 aa) |
| | GACE_1702 | Ribonucleotide-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (756 aa) |
| | GACE_1691 | Butyryl-CoA dehydrogenase. (390 aa) |
| | GACE_1689 | Archaeal histone. (67 aa) |
| | GACE_1685 | Adenylate cyclase. (175 aa) |
| | mfnA | L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (372 aa) |
| | GACE_1673 | AMP/CMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (176 aa) |
| | GACE_1651 | Queuosine biosynthesis protein QueD. (111 aa) |
| | queE | Queuosine biosynthesis protein QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (225 aa) |
| | queC | Queuosine biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (246 aa) |
| | rpoK | DNA-directed RNA polymerase subunit K; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (73 aa) |
| | GACE_1585 | Nicotinamide-nucleotide adenylyltransferase, NadM family. (171 aa) |
| | lig | ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (576 aa) |
| | GACE_1557 | acetyl-CoA synthetase. (646 aa) |
| | guaAA | GMP synthase [glutamine-hydrolyzing], amidotransferase subunit; Catalyzes the synthesis of GMP from XMP. (184 aa) |
| | tfb | Transcription initiation factor B; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (331 aa) |
| | GACE_1473 | Uncharacterized protein, contains DUF137 domain. (238 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (76 aa) |
| | GACE_1467 | DNA-directed RNA polymerase subunit B''; Belongs to the RNA polymerase beta chain family. (488 aa) |
| | GACE_1466 | DNA-directed RNA polymerase subunit B; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (604 aa) |
| | GACE_1465 | DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (867 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A'; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (381 aa) |
| | nusA | NusA family KH domain; Participates in transcription termination. Belongs to the NusA family. (139 aa) |
| | nadK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (258 aa) |
| | GACE_1415 | Pyruvate ferredoxin oxidoreductase, delta subunit. (97 aa) |
| | GACE_1414 | Pyruvate ferredoxin oxidoreductase, gamma subunit. (189 aa) |
| | GACE_1413 | Glutaryl-CoA dehydrogenase. (398 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (86 aa) |
| | GACE_1387 | DNA-directed RNA polymerase subunit F. (116 aa) |
| | GACE_1373 | Replication initiation protein. (991 aa) |
| | GACE_1369 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (452 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (456 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (150 aa) |
| | GACE_1323 | BioD-like N-terminal domain of phosphotransacetylase. (354 aa) |
| | GACE_1310 | Butyryl-CoA dehydrogenase. (364 aa) |
| | GACE_1242 | Hypothetical protein. (292 aa) |
| | GACE_1226 | Iron-sulfur cluster-binding protein. (226 aa) |
| | GACE_1114 | Glucosamine-1-phosphate N-acetyltransferase. (402 aa) |
| | GACE_1113 | Glucose-1-phosphate thymidylyltransferase. (390 aa) |
| | guaAB | GMP synthase subunit B; Catalyzes the synthesis of GMP from XMP. (304 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa) |
| | GACE_0031 | Hypothetical protein. (47 aa) |
| | ribK | Riboflavin kinase; Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN); Belongs to the archaeal riboflavin kinase family. (214 aa) |
| | purM | Phosphoribosylformylglycinamidine cyclo-ligase. (326 aa) |
| | GACE_0136 | Butyryl-CoA dehydrogenase. (378 aa) |
| | GACE_0140 | Indoleyruvate:ferredoxin oxidoreductase beta subunit. (198 aa) |
| | GACE_0143 | Putative preQ0 transporter; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (233 aa) |
