(40 nodes) NAD(P)-binding domain superfamily network (Geoglobus acetivorans)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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	GACE_0770	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa)
	argC	N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (333 aa)
	hemA	Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (440 aa)
	GACE_0133	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative. (676 aa)
	GACE_0135	3-hydroxyacyl-CoA dehydrogenase. (645 aa)
	GACE_0262	Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (295 aa)
	GACE_0422	NADP-dependent malic enzyme. (431 aa)
	gap	Glyceraldehyde-3-phosphate dehydrogenase NAD(P)-dependent, phosphorylating. (335 aa)
	GACE_0572	Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
	GACE_0597	Potassium channel protein. (299 aa)
	GACE_0598	Potassium channel protein. (204 aa)
	GACE_0615	Kef-type K transport system protein. (478 aa)
	GACE_0725	3-hydroxyacyl-CoA dehydrogenase. (286 aa)
	GACE_0765	Cyclohex-1-ene-1-carboxyl-CoA hydratase, BadK; Belongs to the enoyl-CoA hydratase/isomerase family. (659 aa)
	GACE_0768	acetyl-CoA synthetase. (460 aa)
	GACE_0777	2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase, BadH. (251 aa)
	GACE_0791	3-hydroxyacyl-CoA dehydrogenase. (306 aa)
	GACE_0929	Trk system potassium uptake protein TrkA. (402 aa)
	GACE_0935	NADPH-dependent F420 reductase. (218 aa)
	GACE_0946	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (412 aa)
	asd	Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
	GACE_1117	dTDP-glucose 4,6-dehydratase. (329 aa)
	GACE_1120	dTDP-4-dehydrorhamnose reductase. (289 aa)
	GACE_1179	Inositol-1-phosphate synthase. (392 aa)
	GACE_1227	Chorismate mutase/prephenate dehydratase. (635 aa)
	GACE_1260	Siroheme synthase. (230 aa)
	GACE_1271	D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (335 aa)
	aroE	Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (267 aa)
	ala	Alanine dehydrogenase; Catalyzes the NAD(+)-dependent oxidative deamination of L- alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate; Belongs to the ornithine cyclodeaminase/mu-crystallin family. Archaeal alanine dehydrogenase subfamily. (320 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
	GACE_1662	UDP-glucose 4-epimerase. (308 aa)
	GACE_1694	3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (652 aa)
	ahcY	Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (406 aa)
	GACE_1781	Trk system potassium uptake protein TrkA. (433 aa)
	dapB	4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (245 aa)
	GACE_1898	Homoserine dehydrogenase. (331 aa)
	GACE_2052	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (290 aa)
	sucD	Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
	GACE_2156	Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (359 aa)
	GACE_2191	Pyrroline-5-carboxylate reductase. (239 aa)

Your Current Organism:

Geoglobus acetivorans

NCBI taxonomy Id: 565033
Other names: DSM 21716, G. acetivorans, Geoglobus acetivorans Slobodkina et al. 2009, Geoglobus sp. SBH6, VKM B-2522, strain SBH6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GACE_0133	GACE_0135	GACE_0133	GACE_0135	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	3-hydroxyacyl-CoA dehydrogenase.	0.566
GACE_0133	GACE_0262	GACE_0133	GACE_0262	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.568
GACE_0133	GACE_0768	GACE_0133	GACE_0768	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	acetyl-CoA synthetase.	0.999
GACE_0133	gap	GACE_0133	GACE_0477	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	Glyceraldehyde-3-phosphate dehydrogenase NAD(P)-dependent, phosphorylating.	0.698
GACE_0133	sucD	GACE_0133	GACE_2121	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.844
GACE_0135	GACE_0133	GACE_0135	GACE_0133	3-hydroxyacyl-CoA dehydrogenase.	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	0.566
GACE_0135	GACE_0765	GACE_0135	GACE_0765	3-hydroxyacyl-CoA dehydrogenase.	Cyclohex-1-ene-1-carboxyl-CoA hydratase, BadK; Belongs to the enoyl-CoA hydratase/isomerase family.	0.908
GACE_0135	GACE_1694	GACE_0135	GACE_1694	3-hydroxyacyl-CoA dehydrogenase.	3-hydroxyacyl-CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.909
GACE_0262	GACE_0133	GACE_0262	GACE_0133	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Acetyl-CoA synthetase (ADP-forming) alpha and beta chains, putative.	0.568
GACE_0262	GACE_0422	GACE_0262	GACE_0422	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	NADP-dependent malic enzyme.	0.943
GACE_0262	GACE_0768	GACE_0262	GACE_0768	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	acetyl-CoA synthetase.	0.568
GACE_0262	GACE_0777	GACE_0262	GACE_0777	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase, BadH.	0.507
GACE_0262	GACE_0946	GACE_0262	GACE_0946	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.869
GACE_0262	asd	GACE_0262	GACE_1065	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.	0.511
GACE_0262	gap	GACE_0262	GACE_0477	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Glyceraldehyde-3-phosphate dehydrogenase NAD(P)-dependent, phosphorylating.	0.911
GACE_0262	sucD	GACE_0262	GACE_2121	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.881
GACE_0422	GACE_0262	GACE_0422	GACE_0262	NADP-dependent malic enzyme.	Malate dehydrogenase; Belongs to the LDH/MDH superfamily.	0.943
GACE_0422	GACE_0777	GACE_0422	GACE_0777	NADP-dependent malic enzyme.	2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase, BadH.	0.499
GACE_0572	GACE_1898	GACE_0572	GACE_1898	Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Homoserine dehydrogenase.	0.596
GACE_0572	aroE	GACE_0572	GACE_1420	Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Shikimate 5-dehydrogenase I alpha; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).	0.756