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GACE_0127 GACE_0127 GACE_0215 GACE_0215 GACE_0250 GACE_0250 GACE_0262 GACE_0262 GACE_0274 GACE_0274 GACE_0275 GACE_0275 GACE_0276 GACE_0276 GACE_0283 GACE_0283 mch mch cdhE cdhE cdhD cdhD cdhC cdhC cdhB cdhB cdhA cdhA GACE_0361 GACE_0361 GACE_0362 GACE_0362 apgM apgM mer mer GACE_0426 GACE_0426 GACE_0439 GACE_0439 GACE_0463 GACE_0463 GACE_0464 GACE_0464 GACE_0465 GACE_0465 GACE_0466 GACE_0466 GACE_0528 GACE_0528 GACE_0572 GACE_0572 mtd mtd GACE_0695 GACE_0695 GACE_0696 GACE_0696 GACE_0697 GACE_0697 GACE_0698 GACE_0698 GACE_0706 GACE_0706 GACE_0707 GACE_0707 GACE_0708 GACE_0708 GACE_0709 GACE_0709 GACE_0710 GACE_0710 GACE_0711 GACE_0711 GACE_0818 GACE_0818 GACE_0921 GACE_0921 GACE_0931 GACE_0931 GACE_0932 GACE_0932 GACE_0967 GACE_0967 cofD cofD GACE_1230 GACE_1230 aroA-2 aroA-2 GACE_1353 GACE_1353 GACE_1414 GACE_1414 GACE_1415 GACE_1415 GACE_1416 GACE_1416 GACE_1417 GACE_1417 cofE cofE eno eno GACE_1624 GACE_1624 GACE_1625 GACE_1625 mfnA mfnA GACE_1720 GACE_1720 GACE_1724 GACE_1724 glyA glyA GACE_1880 GACE_1880 GACE_1881 GACE_1881 GACE_1882 GACE_1882 GACE_1903 GACE_1903 mfnB mfnB GACE_1916 GACE_1916 GACE_1990 GACE_1990 cofC cofC ftr ftr cofG cofG cofH cofH GACE_2153 GACE_2153 GACE_2155 GACE_2155 fae-hps fae-hps fbp fbp
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GACE_0127Carbon monoxide dehydrogenase, catalytic subunit (cooS). (619 aa)
GACE_0215Phosphoenolpyruvate synthase. (753 aa)
GACE_0250Bifunctional hexulose-6-phosphate synthase/ribonuclease regulator. (432 aa)
GACE_0262Malate dehydrogenase; Belongs to the LDH/MDH superfamily. (295 aa)
GACE_0274Glutamate synthase domain 1. (307 aa)
GACE_0275Glutamate synthase domain 3. (225 aa)
GACE_0276Glutamate synthase domain 2; Belongs to the glutamate synthase family. (483 aa)
GACE_0283Phosphoenolpyruvate carboxylase. (468 aa)
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family. (315 aa)
cdhECO dehydrogenase/acetyl-CoA synthase subunit gamma; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). (472 aa)
cdhDCO dehydrogenase/acetyl-CoA synthase subunit delta; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex. Belongs to the CdhD family. (460 aa)
cdhCCO dehydrogenase/acetyl-CoA synthase subunit beta; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex); Belongs to the CdhC family. (521 aa)
cdhBCO dehydrogenase/acetyl-CoA synthase subunit epsilon; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. Belongs to the CdhB family. (181 aa)
cdhACO dehydrogenase/acetyl-CoA synthase subunit alpha; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. (803 aa)
GACE_0361Formylmethanofuran dehydrogenase subunit B. (405 aa)
GACE_0362Formylmethanofuran dehydrogenase subunit G. (131 aa)
apgMPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (416 aa)
merMethylentetrahydromethanopterin reductase; Catalyzes the oxidation of methyl-H(4)MPT to methylene- H(4)MPT; Belongs to the mer family. (333 aa)
GACE_0426Tetrahydromethanopterin formyl transferase. (302 aa)
GACE_0439Putative ATP-utilizing enzyme. (307 aa)
GACE_0463Formylmethanofuran dehydrogenase subunit C. (234 aa)
GACE_0464Formylmethanofuran dehydrogenase subunit A. (560 aa)
GACE_0465Formylmethanofuran dehydrogenase subunit B. (417 aa)
GACE_0466Formylmethanofuran dehydrogenase subunit D. (122 aa)
GACE_0528Formylmethanofuran dehydrogenase subunit F. (337 aa)
GACE_0572Phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
mtdMethylenetetrahydromethanopterin dehydrogenase; Catalyzes the oxidation of methylene-H(4)MPT to methenyl- H(4)MPT(+). (272 aa)
GACE_0695Pyruvate ferredoxin oxidoreductase, beta subunit. (281 aa)
GACE_0696Pyruvate ferredoxin oxidoreductase, alpha subunit. (371 aa)
GACE_0697Pyruvate ferredoxin oxidoreductase, delta subunit. (83 aa)
GACE_0698Pyruvate ferredoxin oxidoreductase, gamma subunit. (162 aa)
GACE_0706CoB--CoM heterodisulfide reductase subunit A. (651 aa)
GACE_0707CoB--CoM heterodisulfide reductase subunit C. (163 aa)
GACE_0708CoB--CoM heterodisulfide reductase subunit B. (266 aa)
GACE_0709Methylviologen-reducing hydrogenase, subunit delta (MvhD). (128 aa)
GACE_0710Methylviologen-reducing hydrogenase, subunit gamma (MvhG). (299 aa)
GACE_0711Methylviologen-reducing hydrogenase, subunit alpha (MvhA). (446 aa)
GACE_08186-phospho-3-hexuloisomerase. (189 aa)
GACE_0921acetyl-CoA synthetase. (631 aa)
GACE_0931CoB--CoM heterodisulfide reductase subunit B. (266 aa)
GACE_0932CoB--CoM heterodisulfide reductase subunit C. (155 aa)
GACE_0967Sulfopyruvate decarboxylase - beta subunit. (361 aa)
cofD2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. (297 aa)
GACE_1230Fructose-1,6-bisphosphate aldolase. (255 aa)
aroA-2Fructose-1,6-bisphosphate aldolase; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. (264 aa)
GACE_1353N5-methyltetrahydromethanopterin:coenzyme M methyltransferase subunit H. (278 aa)
GACE_1414Pyruvate ferredoxin oxidoreductase, gamma subunit. (189 aa)
GACE_1415Pyruvate ferredoxin oxidoreductase, delta subunit. (97 aa)
GACE_1416Pyruvate ferredoxin oxidoreductase, alpha subunit. (387 aa)
GACE_1417Pyruvate ferredoxin oxidoreductase, beta subunit. (291 aa)
cofEF420-dependent oxidoreductase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives. (252 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (400 aa)
GACE_1624Amino acid kinase. (195 aa)
GACE_1625Hypothetical protein. (305 aa)
mfnAL-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (372 aa)
GACE_1720Bifunctional acetyl-CoA decarbonylase/synthase complex subunit. (385 aa)
GACE_1724Hydrogenase (NiFe), b-type cytochrome subunit. (218 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family. (421 aa)
GACE_1880Phosphoserine phosphatase. (389 aa)
GACE_1881Heterodisulfide reductase, subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). (779 aa)
GACE_1882Formylmethanofuran dehydrogenase subunit F. (433 aa)
GACE_1903Heterodisulfide reductase iron-sulfur subunit D. (391 aa)
mfnBDUF556 family protein; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P). (234 aa)
GACE_1916Phosphoglycerate mutase. (380 aa)
GACE_1990acetyl-CoA synthetase. (678 aa)
cofC2-phospho-L-lactate guanylyltransferase CofC; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. (200 aa)
ftrTetrahydromethanopterin formyl transferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family. (297 aa)
cofG7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (327 aa)
cofH7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. (339 aa)
GACE_21532-ketoisovalerate ferredoxin oxidoreductase, fused subunits gamma and delta. (296 aa)
GACE_21552-ketoisovalerate ferredoxin oxidoreductase, beta subunit. (275 aa)
fae-hpsBifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family. (394 aa)
fbpFructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (366 aa)
Your Current Organism:
Geoglobus acetivorans
NCBI taxonomy Id: 565033
Other names: DSM 21716, G. acetivorans, Geoglobus acetivorans Slobodkina et al. 2009, Geoglobus sp. SBH6, VKM B-2522, strain SBH6
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