(14 nodes) Pantothenate and CoA biosynthesis network (Geoglobus acetivorans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GACE_0280	Phosphopantetheine adenylyltransferase. (151 aa)
	ilvD	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (546 aa)
	GACE_0444	Acetolactate synthase small subunit. (161 aa)
	GACE_0445	Acetolactate synthase large subunit. (555 aa)
	GACE_0770	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa)
	GACE_0913	Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (188 aa)
	GACE_1272	Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (555 aa)
	GACE_1473	Uncharacterized protein, contains DUF137 domain. (238 aa)
	ilvC	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
	mfnA	L-tyrosine decarboxylase; Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily. (372 aa)
	GACE_1883	Phosphopantothenoylcysteine decarboxylase. (400 aa)
	GACE_1884	Pantoate kinase, archaeal. (270 aa)
	ilvE	Hypothetical protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
	GACE_2052	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (290 aa)

Your Current Organism:

Geoglobus acetivorans

NCBI taxonomy Id: 565033
Other names: DSM 21716, G. acetivorans, Geoglobus acetivorans Slobodkina et al. 2009, Geoglobus sp. SBH6, VKM B-2522, strain SBH6

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GACE_0280	GACE_0913	GACE_0280	GACE_0913	Phosphopantetheine adenylyltransferase.	Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	0.943
GACE_0280	GACE_1883	GACE_0280	GACE_1883	Phosphopantetheine adenylyltransferase.	Phosphopantothenoylcysteine decarboxylase.	0.917
GACE_0444	GACE_0445	GACE_0444	GACE_0445	Acetolactate synthase small subunit.	Acetolactate synthase large subunit.	0.999
GACE_0444	GACE_1272	GACE_0444	GACE_1272	Acetolactate synthase small subunit.	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	0.998
GACE_0444	ilvC	GACE_0444	GACE_1522	Acetolactate synthase small subunit.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.999
GACE_0444	ilvD	GACE_0444	GACE_0290	Acetolactate synthase small subunit.	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.	0.895
GACE_0444	ilvE	GACE_0444	GACE_1900	Acetolactate synthase small subunit.	Hypothetical protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.824
GACE_0445	GACE_0444	GACE_0445	GACE_0444	Acetolactate synthase large subunit.	Acetolactate synthase small subunit.	0.999
GACE_0445	GACE_1272	GACE_0445	GACE_1272	Acetolactate synthase large subunit.	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	0.918
GACE_0445	ilvC	GACE_0445	GACE_1522	Acetolactate synthase large subunit.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.987
GACE_0445	ilvD	GACE_0445	GACE_0290	Acetolactate synthase large subunit.	Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.	0.975
GACE_0445	ilvE	GACE_0445	GACE_1900	Acetolactate synthase large subunit.	Hypothetical protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.773
GACE_0770	GACE_1884	GACE_0770	GACE_1884	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	Pantoate kinase, archaeal.	0.918
GACE_0770	GACE_2052	GACE_0770	GACE_2052	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.	0.921
GACE_0913	GACE_0280	GACE_0913	GACE_0280	Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	Phosphopantetheine adenylyltransferase.	0.943
GACE_0913	GACE_1473	GACE_0913	GACE_1473	Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	Uncharacterized protein, contains DUF137 domain.	0.457
GACE_0913	GACE_1884	GACE_0913	GACE_1884	Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).	Pantoate kinase, archaeal.	0.453
GACE_1272	GACE_0444	GACE_1272	GACE_0444	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	Acetolactate synthase small subunit.	0.998
GACE_1272	GACE_0445	GACE_1272	GACE_0445	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	Acetolactate synthase large subunit.	0.918
GACE_1272	ilvC	GACE_1272	GACE_1522	Acetolactate synthase large subunit; Belongs to the TPP enzyme family.	Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.	0.984