145 items (Leishmania braziliensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LBRM_33_0250	Adenosine deaminase-like protein. (292 aa)
	LBRM_35_4750	Putative 60S ribosomal protein L18. (198 aa)
	LBRM_35_4640	ATP-dependent RNA helicase-like protein. (974 aa)
	LBRM_35_4460	Uncharacterized protein. (987 aa)
	LBRM_31_0820	FtsJ domain-containing protein. (331 aa)
	LBRM_24_0560	Uncharacterized protein. (437 aa)
	LBRM_20_5830	Contig, possible fusion of chromosomes 20 and 34. (316 aa)
	LBRM_20_5570	Contig, possible fusion of chromosomes 20 and 34. (403 aa)
	LBRM_20_5100	Contig, possible fusion of chromosomes 20 and 34. (598 aa)
	LBRM_20_4880	Contig, possible fusion of chromosomes 20 and 34. (742 aa)
	LBRM_20_4670	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (374 aa)
	LBRM_35_6860	Uncharacterized protein. (700 aa)
	LBRM_35_6730	Putative 40S ribosomal protein S8. (260 aa)
	LBRM_35_5140	Putative exosome-associated protein 4. (221 aa)
	LBRM_35_4960	WD_REPEATS_REGION domain-containing protein. (726 aa)
	LBRM_35_4900	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (227 aa)
	LBRM_35_4830	Uncharacterized protein. (452 aa)
	LBRM_26_0510	DNA polymerase sigma-like protein. (519 aa)
	LBRM_26_0030	Brix domain containing-like protein. (362 aa)
	LbrM_25_2130	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1567 aa)
	PUF8	PUF8 protein. (577 aa)
	LBRM_25_1280	DNA-directed RNA polymerase ii. (84 aa)
	LBRM_25_0380	Uncharacterized protein. (968 aa)
	LBRM_25_0140	Uncharacterized protein. (129 aa)
	LBRM_24_2340	Putative notchless homolog. (522 aa)
	LBRM_24_2150	40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family. (219 aa)
	LBRM_24_0550	TRM13 domain-containing protein. (399 aa)
	LBRM_24_0240	Putative ATP-dependent RNA helicase. (606 aa)
	LBRM_23_0570	Ribosomal RNA methyltransferase-like protein. (285 aa)
	LBRM_23_0320	Checkpoint protein; Belongs to the HUS1 family. (323 aa)
	LBRM_23_0040	Putative beta propeller protein. (478 aa)
	LBRM_22_1260	Protein MAK16 homolog; Belongs to the MAK16 family. (268 aa)
	LBRM_20_3910	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (225 aa)
	LBRM_20_3610	Contig, possible fusion of chromosomes 20 and 34. (148 aa)
	LBRM_20_2660	Contig, possible fusion of chromosomes 20 and 34. (735 aa)
	LBRM_20_2350	Contig, possible fusion of chromosomes 20 and 34. (602 aa)
	LBRM_20_2300	Contig, possible fusion of chromosomes 20 and 34. (425 aa)
	LBRM_20_1540	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (803 aa)
	RH-2	RH protein. (772 aa)
	LBRM_20_1140	Contig, possible fusion of chromosomes 20 and 34. (530 aa)
	RH	RH protein. (775 aa)
	LBRM_20_0860	Contig, possible fusion of chromosomes 20 and 34. (159 aa)
	LBRM_20_0670	Contig, possible fusion of chromosomes 20 and 34. (468 aa)
	LBRM_19_1360	PINc domain-containing protein. (209 aa)
	LBRM_19_0990	Putative U3 snoRNA-associated protein UTP11. (360 aa)
	LBRM_19_0980	Putative DNA-directed RNA polymerase, alpha subunit. (446 aa)
	LBRM_19_0740	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (162 aa)
	LBRM_19_0410	Putative fibrillarin. (433 aa)
	LBRM_18_1640	Uncharacterized protein. (654 aa)
	LBRM_18_1480	Uncharacterized protein. (2016 aa)
	LBRM_18_1020	Uncharacterized protein. (1268 aa)
	LBRM_18_1000	Uncharacterized protein. (120 aa)
	LBRM_18_0880	Putative DNA-directed RNA polymerase II. (322 aa)
	LBRM_18_0870	Putative DNA-directed RNA polymerases II. (239 aa)
	LBRM_17_1500	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (865 aa)
	LBRM_17_1410	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1080 aa)
	GMPR	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (492 aa)
	LBRM_16_1450	Uncharacterized protein. (287 aa)
	LBRM_16_1400	Putative DNA-directed rna polymerase I largest subunit. (1814 aa)
	LBRM_16_0060	Uncharacterized protein. (657 aa)
	LBRM_15_1470	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	LBRM_15_1380	Putative nucleolar RNA binding protein. (444 aa)
	LBRM_15_0130	Putative ATP-dependent RNA helicase. (683 aa)
	LBRM_14_1410	Uncharacterized protein. (286 aa)
	LBRM_14_0550	Uncharacterized protein. (1156 aa)
	LBRM_14_0420	Uncharacterized protein. (1068 aa)
	LBRM_14_0260	VWFA domain-containing protein. (716 aa)
	LBRM_13_1360	WD_REPEATS_REGION domain-containing protein. (758 aa)
	LBRM_13_0920	Putative DNA-directed RNA polymerase ii 8.2 Kd polypeptide. (89 aa)
	LBRM_13_0380	Putative 60S ribosomal protein L18. (198 aa)
	LBRM_12_0590	Uncharacterized protein. (1822 aa)
	LBRM_12_0580	Uncharacterized protein. (1853 aa)
	LBRM_11_0700	Putative 60S ribosomal protein L24. (190 aa)
	LBRM_11_0230	WD_REPEATS_REGION domain-containing protein. (680 aa)
	LbrM11_V2.0090	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (743 aa)
	LBRM_10_1130	RNA-binding protein-like protein. (390 aa)
	LBRM_10_0830	Uncharacterized protein. (943 aa)
	LBRM_10_0210	Putative nucleolar protein. (471 aa)
	LBRM_10_0100	SRP40_C domain-containing protein. (253 aa)
	LBRM_09_0020	Uncharacterized protein. (373 aa)
	LBRM_07_0770	Topoisomerase-related function protein-like protein. (892 aa)
	LBRM_07_0640	CLP1_P domain-containing protein. (1345 aa)
	LBRM_07_0490	Uncharacterized protein. (780 aa)
	LBRM_06_1000	G-patch domain-containing protein. (230 aa)
	LBRM_05_1110	DNA-directed RNA polymerase I largest subunit. (250 aa)
	LBRM_05_0650	Nitroreductase-like protein. (295 aa)
	LBRM_05_0470	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (640 aa)
	LBRM_05_0360	Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (630 aa)
	LbrM04_V2.0780	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (670 aa)
	LBRM_04_0170	Putative exosome complex exonuclease RRP40. (300 aa)
	LBRM_02_0640	Uncharacterized protein. (906 aa)
	LBRM_26_1270	Uncharacterized protein. (699 aa)
	LBRM_30_1270	MI domain-containing protein. (900 aa)
	LBRM_30_1420	Putative U3 small nuclear ribonucleoprotein (SnRNP). (288 aa)
	LBRM_30_3000	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (322 aa)
	LBRM_30_3290	Putative ATP-dependent RNA helicase. (1026 aa)
	LBRM_31_0310	WD_REPEATS_REGION domain-containing protein. (448 aa)
	LBRM_31_0560	Adenosine deaminase-like protein. (598 aa)
	LBRM_31_0680	CHHC U11-48K-type domain-containing protein. (705 aa)
	LBRM_31_2660	WD_REPEATS_REGION domain-containing protein. (482 aa)
	LBRM_31_3350	SMK-1 domain-containing protein. (988 aa)
	LBRM_32_0210	Uncharacterized protein. (993 aa)
	LBRM_32_0650	Putative RNA helicase. (584 aa)
	LBRM_32_0770	Uncharacterized protein. (63 aa)
	LBRM_32_3750	Putative exosome-associated protein 2. (312 aa)
	LBRM_33_1620	60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (181 aa)
	LBRM_33_2140	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (652 aa)
	LBRM_33_2190	WD_REPEATS_REGION domain-containing protein. (584 aa)
	LBRM_33_2430	WD_REPEATS_REGION domain-containing protein. (867 aa)
	LBRM_33_2680	Putative ras-like small GTPases. (565 aa)
	LBRM_34_1320	RRM domain-containing protein. (232 aa)
	LBRM_34_1730	Uncharacterized protein. (273 aa)
	LBRM_34_1900	Uncharacterized protein. (1058 aa)
	LBRM_34_2420	Uncharacterized protein. (340 aa)
	LBRM_34_2900	Uncharacterized protein. (412 aa)
	LBRM_34_3470	KH domain-containing protein. (221 aa)
	LBRM_34_3860	WD_REPEATS_REGION domain-containing protein. (444 aa)
	LBRM_34_4010	RNA helicase. (691 aa)
	LBRM_35_0430	Putative nuclear protein family a (Nop10p). (63 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (249 aa)
	LBRM_35_2070	Uncharacterized protein. (633 aa)
	LBRM_35_3240	Putative exosome complex exonuclease rrp41. (246 aa)
	LBRM_35_3290	Fibrillarin. (233 aa)
	LBRM_35_3880	Uncharacterized protein. (393 aa)
	LBRM_30_0700	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (216 aa)
	LBRM_30_0560	Putative bystin. (469 aa)
	LBRM_29_1480	Putative RNA binding protein. (287 aa)
	LBRM_29_1470	Putative RNA binding protein. (322 aa)
	LBRM_29_0770	Putative U3 small nucleolar ribonucleoprotein protein MPP10. (682 aa)
	LBRM_28_2250	DNA-directed RNA polymerase-like protein. (137 aa)
	LBRM_28_2050	Bms1-type G domain-containing protein. (1256 aa)
	LBRM_28_1910	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (583 aa)
	LBRM_28_1700	Putative DEAD box RNA helicase; Belongs to the DEAD box helicase family. (389 aa)
	LBRM_28_1410	Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (897 aa)
	LBRM_28_0850	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (149 aa)
	LBRM_28_0750	Sas10 domain-containing protein. (551 aa)
	LBRM_28_0480	WD_REPEATS_REGION domain-containing protein. (795 aa)
	LBRM_28_0130	Putative DNA-direcetd RNA polymerase II, subunit 9. (140 aa)
	LBRM_27_2430	Uncharacterized protein. (246 aa)
	LBRM_27_2160	Putative rRNA methyltransferase; Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits. (927 aa)
	LBRM_27_0540	Ribosome biogenesis protein. (330 aa)
	LBRM_27_0390	Kri1_C domain-containing protein. (1055 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	LBRM_27_0060	RNA helicase. (690 aa)
	LBRM_26_1720	Uncharacterized protein. (2767 aa)

Your Current Organism:

Leishmania braziliensis

NCBI taxonomy Id: 5660
Other names: L. braziliensis, Leishmania (V.) braziliensis, Leishmania (Viannia) braziliensis, Leishmania brasiliensis, Leishmania viannia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF6	LBRM_05_0470	A4HNU9	A4H492	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.	0.997
EIF6	LBRM_09_0020	A4HNU9	A4H5H7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.997
EIF6	LBRM_10_1130	A4HNU9	A4H691	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	RNA-binding protein-like protein.	0.996
EIF6	LBRM_11_0700	A4HNU9	A4H6L6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Putative 60S ribosomal protein L24.	0.999
EIF6	LBRM_13_0380	A4HNU9	A4H745	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Putative 60S ribosomal protein L18.	0.878
EIF6	LBRM_15_0130	A4HNU9	A4H7Y3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Putative ATP-dependent RNA helicase.	0.734
EIF6	LBRM_15_1380	A4HNU9	A4H8A6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Putative nucleolar RNA binding protein.	0.569
EIF6	LBRM_15_1470	A4HNU9	A4H8B5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.892
EIF6	LBRM_16_0060	A4HNU9	A4H8D2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.818
EIF6	LBRM_16_1450	A4HNU9	A4H8R8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.404
EIF6	LBRM_17_1500	A4HNU9	A4H993	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.778
EIF6	LBRM_18_1640	A4HNU9	A4H9R2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.956
EIF6	LBRM_19_0410	A4HNU9	A4H9W7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Putative fibrillarin.	0.651
EIF6	LBRM_19_0980	A4HNU9	A4HA24	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Putative DNA-directed RNA polymerase, alpha subunit.	0.408
EIF6	LBRM_20_1140	A4HNU9	A4HAM9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Contig, possible fusion of chromosomes 20 and 34.	0.717
EIF6	LBRM_20_1540	A4HNU9	A4HAR7	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.547
EIF6	LBRM_20_3610	A4HNU9	A4HBC1	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Contig, possible fusion of chromosomes 20 and 34.	0.881
EIF6	LBRM_20_5830	A4HNU9	E9AIL5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Contig, possible fusion of chromosomes 20 and 34.	0.945
EIF6	LBRM_22_1260	A4HNU9	A4HCH9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Protein MAK16 homolog; Belongs to the MAK16 family.	0.889
EIF6	LBRM_23_0570	A4HNU9	A4HCR8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal RNA methyltransferase-like protein.	0.775

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