(79 nodes) Nucleic acid phosphodiester bond hydrolysis network (Leishmania braziliensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	LBRM_29_0480	Exonuclease domain-containing protein. (508 aa)
	LBRM_28_2050	Bms1-type G domain-containing protein. (1256 aa)
	LBRM_28_0550	RAD50 DNA repair-like protein. (1361 aa)
	LBRM_28_0460	Putative ribonuclease II-like protein; Belongs to the RNR ribonuclease family. (929 aa)
	LBRM_28_0340	Putative rrp44p homologue; Belongs to the RNR ribonuclease family. (920 aa)
	LBRM_28_0130	Putative DNA-direcetd RNA polymerase II, subunit 9. (140 aa)
	LBRM_27_2030	Putative endo/exonuclease Mre11. (863 aa)
	LBRM_27_1080	Uncharacterized protein. (379 aa)
	LBRM_27_1020	XRN_N domain-containing protein. (592 aa)
	LBRM_27_0390	Kri1_C domain-containing protein. (1055 aa)
	FEN1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
	LBRM_26_0200	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (406 aa)
	LBRM_25_0380	Uncharacterized protein. (968 aa)
	LBRM_25_0170	Cleavage and polyadenylation specificity factor subunit 2. (829 aa)
	LBRM_24_2360	Putative TFIIH basal transcription factor complex helicase subunit. (813 aa)
	LBRM_24_1340	SAP domain-containing protein. (1144 aa)
	LBRM_24_0830	Putative phosphotransferase. (575 aa)
	LBRM_23_1390	Uncharacterized protein. (1009 aa)
	LBRM_23_0600	Putative 5'-3' exonuclease XRNC. (1065 aa)
	LBRM_22_1540	Putative CCR4 associated factor. (338 aa)
	LBRM_22_1490	Putative exosome complex exonuclease RRP45 homolog. (363 aa)
	LBRM_21_0470	Putative argonaut-like protein. (1211 aa)
	LBRM_20_3010	Contig, possible fusion of chromosomes 20 and 34. (756 aa)
	LBRM_20_2840	Contig, possible fusion of chromosomes 20 and 34. (657 aa)
	LBRM_20_2660	Contig, possible fusion of chromosomes 20 and 34. (735 aa)
	LBRM_20_1720	Contig, possible fusion of chromosomes 20 and 34. (845 aa)
	LBRM_20_1270	Contig, possible fusion of chromosomes 20 and 34. (527 aa)
	LBRM_19_0740	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (162 aa)
	LBRM_17_1260	Putative 5'-3' exonuclease. (1108 aa)
	LBRM_17_1030	Uncharacterized protein. (630 aa)
	LBRM_16_0670	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (444 aa)
	LBRM_16_0620	TP6A_N domain-containing protein. (653 aa)
	LBRM_16_0400	XRN_N domain-containing protein. (993 aa)
	LBRM_16_0200	Uncharacterized protein. (357 aa)
	LBRM_14_0010	Putative exosome complex exonuclease. (303 aa)
	LBRM_13_1040	DNA/RNA non-specific endonuclease-like protein. (877 aa)
	LBRM_13_0050	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (255 aa)
	LBRM_11_1030	Putative tatD related deoxyribonuclease. (336 aa)
	LBRM_11_0360	Uncharacterized protein. (898 aa)
	LBRM_10_0750	Putative endonuclease G. (504 aa)
	LBRM_10_0290	Exonuclease domain-containing protein. (928 aa)
	NTH1	Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (259 aa)
	LBRM_08_0730	Uncharacterized protein. (2087 aa)
	LBRM_08_0150	Putative DNA repair protein. (1261 aa)
	LBRM_07_0640	CLP1_P domain-containing protein. (1345 aa)
	LBRM_07_0490	Uncharacterized protein. (780 aa)
	LBRM_06_0550	Uncharacterized protein. (849 aa)
	LBRM_06_0240	Putative 5'-3' exonuclease. (1513 aa)
	LBRM_04_0360	Putative mitochondrial exoribonuclease DSS-1. (838 aa)
	LBRM_04_0170	Putative exosome complex exonuclease RRP40. (300 aa)
	LBRM_03_0650	Uncharacterized protein. (783 aa)
	LBRM_01_0050	Endo/exonuclease/phosphatase domain-containing protein. (553 aa)
	LBRM_35_5520	Endonuclease/exonuclease protein-like protein. (745 aa)
	LBRM_25_1030	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (701 aa)
	LBRM_20_5570	Contig, possible fusion of chromosomes 20 and 34. (403 aa)
	LBRM_35_5310	Uncharacterized protein; Belongs to the NOB1 family. (440 aa)
	LBRM_35_3000	Uncharacterized protein. (526 aa)
	LBRM_35_2830	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1744 aa)
	LBRM_35_2560	Putative endonuclease V. (395 aa)
	LBRM_35_1980	Putative exoribonuclease 2. (899 aa)
	LBRM_35_0760	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (318 aa)
	LBRM_35_0420	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (474 aa)
	LBRM_34_5110	Uncharacterized protein. (305 aa)
	LBRM_34_4340	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2305 aa)
	LBRM_34_3550	Putative DNA repair protein RAD2. (1029 aa)
	LBRM_34_2900	Uncharacterized protein. (412 aa)
	TDBP1	TDBP1 protein. (680 aa)
	LBRM_33_1960	DNA polymerase. (1032 aa)
	LBRM_32_4160	Putative DNA repair helicase. (803 aa)
	LBRM_32_3750	Putative exosome-associated protein 2. (312 aa)
	LBRM_31_3040	Uncharacterized protein. (913 aa)
	LBRM_30_0700	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (216 aa)
	LBRM_30_0260	Putative ubiquitin hydrolase. (1128 aa)
	LBRM_29_0650	zf-C2HE domain-containing protein. (265 aa)
	LBRM_29_0600	Putative DNA repair helicase. (1108 aa)
	LBRM_29_0570	Exonuclease domain-containing protein. (405 aa)
	LBRM_29_0560	Uncharacterized protein. (241 aa)
	LBRM_29_0490	Exonuclease domain-containing protein. (881 aa)
	LbrM_28_3260	Endonuclease/exonuclease/phosphatase-like protein. (1100 aa)

Your Current Organism:

Leishmania braziliensis

NCBI taxonomy Id: 5660
Other names: L. braziliensis, Leishmania (V.) braziliensis, Leishmania (Viannia) braziliensis, Leishmania brasiliensis, Leishmania viannia

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FEN1	LBRM_08_0150	A4HFE4	A4H581	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative DNA repair protein.	0.732
FEN1	LBRM_10_0750	A4HFE4	A4H653	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative endonuclease G.	0.426
FEN1	LBRM_13_1040	A4HFE4	A4H7B0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA/RNA non-specific endonuclease-like protein.	0.426
FEN1	LBRM_16_0670	A4HFE4	A4H8J0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family.	0.821
FEN1	LBRM_20_1270	A4HFE4	A4HAP1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Contig, possible fusion of chromosomes 20 and 34.	0.698
FEN1	LBRM_23_1390	A4HFE4	A4HD00	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.912
FEN1	LBRM_24_1340	A4HFE4	A4HDI9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	SAP domain-containing protein.	0.813
FEN1	LBRM_24_2360	A4HFE4	A4HDT9	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative TFIIH basal transcription factor complex helicase subunit.	0.645
FEN1	LBRM_25_1030	A4HFE4	E9AIR5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family.	0.585
FEN1	LBRM_27_2030	A4HFE4	A4HFW3	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative endo/exonuclease Mre11.	0.981
FEN1	LBRM_28_0550	A4HFE4	A4HG93	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	RAD50 DNA repair-like protein.	0.961
FEN1	LBRM_29_0600	A4HFE4	A4HH67	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative DNA repair helicase.	0.690
FEN1	LBRM_29_0650	A4HFE4	A4HH71	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	zf-C2HE domain-containing protein.	0.457
FEN1	LBRM_31_3040	A4HFE4	A4HJQ7	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.698
FEN1	LBRM_32_4160	A4HFE4	A4HL29	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Putative DNA repair helicase.	0.690
FEN1	LBRM_33_1960	A4HFE4	A4HLN0	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase.	0.993
FEN1	LBRM_34_4340	A4HFE4	A4HNA5	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.907
FEN1	LBRM_34_5110	A4HFE4	A4HNH8	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Uncharacterized protein.	0.426
FEN1	LBRM_35_0760	A4HFE4	A4HNS4	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.	0.668
FEN1	LBRM_35_5520	A4HFE4	E9AIY2	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	Endonuclease/exonuclease protein-like protein.	0.821

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