(39 nodes) Anaphase-promoting complex, and Regulation of cell cycle network (Leishmania major)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LMJF_27_0560	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (327 aa)
	LMJF_29_2720	Putative serine/threonine protein kinase. (323 aa)
	LMJF_35_3750	CULLIN_2 domain-containing protein; Belongs to the cullin family. (875 aa)
	LMJF_35_4500	Putative anaphase promoting complex subunit protein. (82 aa)
	CRK3	Cell division related protein kinase 2; Belongs to the protein kinase superfamily. (311 aa)
	LMJF_36_5350	Uncharacterized protein. (1255 aa)
	LMJF_36_2035	WD_REPEATS_REGION domain-containing protein. (682 aa)
	LMJF_36_1820	Putative ras-like small GTPases. (873 aa)
	LMJF_34_0940	Putative serine/threonine-protein kinase. (1001 aa)
	LMJF_33_2770	Putative ubiquitin-conjugating enzyme; Belongs to the ubiquitin-conjugating enzyme family. (243 aa)
	LMJF_33_0370	WD_REPEATS_REGION domain-containing protein. (728 aa)
	CKS1	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (99 aa)
	CYC6	Putative cyclin; Belongs to the cyclin family. (303 aa)
	LMJF_30_3090	Uncharacterized protein. (338 aa)
	LMJF_30_1990	Cyclosome subunit-like protein. (2162 aa)
	LMJF_30_0710	Putative CDC16. (546 aa)
	LMJF_28_1790	ATPase-like protein; Belongs to the AAA ATPase family. (591 aa)
	LMJF_26_2510	Uncharacterized protein; Belongs to the protein kinase superfamily. (481 aa)
	LMJF_26_2440	Protein kinase domain-containing protein. (1043 aa)
	LMJF_26_0370	Uncharacterized protein. (853 aa)
	CYC8	Putative mitotic cyclin. (448 aa)
	LMJF_25_1670	Putative mitotic spindle checkpoint component. (201 aa)
	CYCA	Cyclin; Belongs to the cyclin family. (309 aa)
	LMJF_24_2130	Putative ubiquitin-conjugating enzyme e2; Belongs to the ubiquitin-conjugating enzyme family. (155 aa)
	LMJF_24_1720	Putative cell division cycle protein. (838 aa)
	LMJF_20_1680	Putative separin. (1279 aa)
	LMJF_19_1470	Protein kinase domain-containing protein. (621 aa)
	LMJF_17_0790	Serine/threonine-protein kinase PLK. (702 aa)
	LMJF_17_0060	Putative mitogen-activated protein kinase kinase 3. (553 aa)
	CRK	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (466 aa)
	LMJF_16_0870	Protein kinase domain-containing protein. (684 aa)
	LMJF_16_0650	RING-type domain-containing protein. (105 aa)
	LMJF_15_0710	Uncharacterized protein. (3115 aa)
	LMJF_12_0610	TPR_REGION domain-containing protein. (1025 aa)
	LMJF_12_0470	Uncharacterized protein. (751 aa)
	LMJF_09_0420	Putative tyrosine phosphatase. (997 aa)
	LMJF_05_0550	Putative cdc2-related kinase; Belongs to the protein kinase superfamily. (319 aa)
	LMJF_05_0410	TPR_REGION domain-containing protein. (920 aa)
	LMJF_04_0400	Anaphase promoting complex, subunit 10-like protein. (340 aa)

Your Current Organism:

Leishmania major

NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CKS1	CRK	Q4Q4P3	Q4QES1	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.914
CKS1	CRK3	Q4Q4P3	O96526	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Cell division related protein kinase 2; Belongs to the protein kinase superfamily.	0.948
CKS1	CYC6	Q4Q4P3	Q4Q4U0	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative cyclin; Belongs to the cyclin family.	0.840
CKS1	CYC8	Q4Q4P3	Q4Q9F8	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative mitotic cyclin.	0.840
CKS1	CYCA	Q4Q4P3	Q4Q9U4	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Cyclin; Belongs to the cyclin family.	0.840
CKS1	LMJF_05_0550	Q4Q4P3	Q4QJE7	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative cdc2-related kinase; Belongs to the protein kinase superfamily.	0.837
CKS1	LMJF_12_0470	Q4Q4P3	Q4QGP5	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Uncharacterized protein.	0.400
CKS1	LMJF_20_1680	Q4Q4P3	Q4QCN4	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative separin.	0.537
CKS1	LMJF_24_1720	Q4Q4P3	Q4QAF9	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative cell division cycle protein.	0.636
CKS1	LMJF_24_2130	Q4Q4P3	Q4QAB7	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative ubiquitin-conjugating enzyme e2; Belongs to the ubiquitin-conjugating enzyme family.	0.589
CKS1	LMJF_25_1670	Q4Q4P3	Q4Q9S3	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative mitotic spindle checkpoint component.	0.684
CKS1	LMJF_26_2440	Q4Q4P3	Q4Q8U7	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Protein kinase domain-containing protein.	0.420
CKS1	LMJF_27_0560	Q4Q4P3	E9AD33	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.837
CKS1	LMJF_29_2720	Q4Q4P3	E9AED4	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative serine/threonine protein kinase.	0.612
CKS1	LMJF_33_0370	Q4Q4P3	Q4Q4H0	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	WD_REPEATS_REGION domain-containing protein.	0.636
CKS1	LMJF_34_0940	Q4Q4P3	Q4Q3B1	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	Putative serine/threonine-protein kinase.	0.612
CKS1	LMJF_36_2035	Q4Q4P3	Q4Q1L9	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	WD_REPEATS_REGION domain-containing protein.	0.636
CRK	CKS1	Q4QES1	Q4Q4P3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.914
CRK	CRK3	Q4QES1	O96526	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Cell division related protein kinase 2; Belongs to the protein kinase superfamily.	0.621
CRK	CYC6	Q4QES1	Q4Q4U0	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Putative cyclin; Belongs to the cyclin family.	0.839