(25 nodes) Thioredoxin domain network (Leishmania major)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TXN2	Tryparedoxin. (149 aa)
	LMJF_26_0660	Uncharacterized protein; Belongs to the protein disulfide isomerase family. (377 aa)
	TRYP1	Tryparedoxin peroxidase. (199 aa)
	LMJF_06_1190	Thioredoxin domain-containing protein. (189 aa)
	PDI-1	Protein disulfide isomerase; Belongs to the protein disulfide isomerase family. (133 aa)
	L7845.03	Uncharacterized protein L7845.03. (562 aa)
	LMJF_26_0670	Thioredoxin domain-containing protein. (167 aa)
	QSOX	Sulfhydryl oxidase. (552 aa)
	LMJF_29_1140	Tryparedoxin-like protein. (275 aa)
	LMJF_23_0040	Peroxidoxin. (226 aa)
	TXN1	Tryparedoxin. (145 aa)
	LMJF_29_1650	Thioredoxin domain-containing protein. (112 aa)
	LMJF_35_0380	Thioredoxin domain-containing protein. (616 aa)
	LMJF_35_1250	Thioredoxin-like protein. (228 aa)
	PDI-2	Protein disulfide-isomerase. (477 aa)
	LMJF_34_2200	Thioredoxin domain-containing protein. (433 aa)
	LMJF_33_1280	Thioredoxin domain-containing protein. (167 aa)
	LMJF_31_1970	Tryparedoxin-like protein. (180 aa)
	LMJF_31_1960	Tryparedoxin-like protein. (186 aa)
	LMJF_30_1010	Putative ubiquitin conjugation factor E4 B. (1022 aa)
	LMJF_27_2200	Thioredoxin domain-containing protein. (239 aa)
	LMJF_01_0270	Thioredoxin; Belongs to the thioredoxin family. (107 aa)
	TRYP4	Tryparedoxin peroxidase. (190 aa)
	TRYP7	Thiol specific antioxidant. (199 aa)
	TRYP3	Tryparedoxin peroxidase. (199 aa)

Your Current Organism:

Leishmania major

NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
L7845.03	LMJF_23_0040	Q9GRP8	Q4QBH2	Uncharacterized protein L7845.03.	Peroxidoxin.	0.498
L7845.03	TRYP1	Q9GRP8	Q4QF80	Uncharacterized protein L7845.03.	Tryparedoxin peroxidase.	0.498
L7845.03	TRYP3	Q9GRP8	Q4QF76	Uncharacterized protein L7845.03.	Tryparedoxin peroxidase.	0.498
L7845.03	TRYP4	Q9GRP8	Q4QF74	Uncharacterized protein L7845.03.	Tryparedoxin peroxidase.	0.498
L7845.03	TRYP7	Q9GRP8	Q4QF68	Uncharacterized protein L7845.03.	Thiol specific antioxidant.	0.498
LMJF_01_0270	LMJF_23_0040	E9AC16	Q4QBH2	Thioredoxin; Belongs to the thioredoxin family.	Peroxidoxin.	0.688
LMJF_01_0270	LMJF_30_1010	E9AC16	Q4Q7K2	Thioredoxin; Belongs to the thioredoxin family.	Putative ubiquitin conjugation factor E4 B.	0.451
LMJF_01_0270	QSOX	E9AC16	Q4Q7R5	Thioredoxin; Belongs to the thioredoxin family.	Sulfhydryl oxidase.	0.742
LMJF_01_0270	TRYP1	E9AC16	Q4QF80	Thioredoxin; Belongs to the thioredoxin family.	Tryparedoxin peroxidase.	0.688
LMJF_01_0270	TRYP3	E9AC16	Q4QF76	Thioredoxin; Belongs to the thioredoxin family.	Tryparedoxin peroxidase.	0.688
LMJF_01_0270	TRYP4	E9AC16	Q4QF74	Thioredoxin; Belongs to the thioredoxin family.	Tryparedoxin peroxidase.	0.688
LMJF_01_0270	TRYP7	E9AC16	Q4QF68	Thioredoxin; Belongs to the thioredoxin family.	Thiol specific antioxidant.	0.688
LMJF_01_0270	TXN1	E9AC16	E9ADX4	Thioredoxin; Belongs to the thioredoxin family.	Tryparedoxin.	0.585
LMJF_01_0270	TXN2	E9AC16	E9ADX3	Thioredoxin; Belongs to the thioredoxin family.	Tryparedoxin.	0.585
LMJF_06_1190	LMJF_23_0040	Q4QIV7	Q4QBH2	Thioredoxin domain-containing protein.	Peroxidoxin.	0.493
LMJF_06_1190	TRYP1	Q4QIV7	Q4QF80	Thioredoxin domain-containing protein.	Tryparedoxin peroxidase.	0.493
LMJF_06_1190	TRYP3	Q4QIV7	Q4QF76	Thioredoxin domain-containing protein.	Tryparedoxin peroxidase.	0.493
LMJF_06_1190	TRYP4	Q4QIV7	Q4QF74	Thioredoxin domain-containing protein.	Tryparedoxin peroxidase.	0.493
LMJF_06_1190	TRYP7	Q4QIV7	Q4QF68	Thioredoxin domain-containing protein.	Thiol specific antioxidant.	0.493
LMJF_23_0040	L7845.03	Q4QBH2	Q9GRP8	Peroxidoxin.	Uncharacterized protein L7845.03.	0.498