(15 nodes) (2015) Regulation of Leishmania (L.) amazonensis protein expression by host T cell dependent responses: differential expression of oligopeptidase B, tryparedoxin peroxidase and HSP70 isoforms in amastigotes isolated from BALBc and BALBc nude mice. network (Leishmania major)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRYP7	Thiol specific antioxidant. (199 aa)
	TRYP4	Tryparedoxin peroxidase. (190 aa)
	TRYP3	Tryparedoxin peroxidase. (199 aa)
	TRYP1	Tryparedoxin peroxidase. (199 aa)
	HSP83-2	Heat shock protein 83-1. (701 aa)
	LMJF_33_0792	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (443 aa)
	LMJF_35_4020	Serine peptidase. (394 aa)
	TXN1	Tryparedoxin. (145 aa)
	TXN2	Tryparedoxin. (149 aa)
	ALAT	Alanine aminotransferase. (497 aa)
	OPB	Oligopeptidase b. (731 aa)
	LMJF_08_1230	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (443 aa)
	TRYR	Trypanothione reductase. (491 aa)
	LMJF_23_0040	Peroxidoxin. (226 aa)
	LMJF_21_1860	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (443 aa)

Your Current Organism:

Leishmania major

NCBI taxonomy Id: 5664
Other names: L. major, Leishmania (Leishmania) major, Leishmania tropica major

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HSP83-2	LMJF_08_1230	Q4Q4I6	Q4QI42	Heat shock protein 83-1.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.562
HSP83-2	LMJF_21_1860	Q4Q4I6	Q4QBZ6	Heat shock protein 83-1.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.562
HSP83-2	LMJF_23_0040	Q4Q4I6	Q4QBH2	Heat shock protein 83-1.	Peroxidoxin.	0.424
HSP83-2	LMJF_33_0792	Q4Q4I6	Q4Q4C4	Heat shock protein 83-1.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.562
HSP83-2	TRYP1	Q4Q4I6	Q4QF80	Heat shock protein 83-1.	Tryparedoxin peroxidase.	0.579
HSP83-2	TRYP3	Q4Q4I6	Q4QF76	Heat shock protein 83-1.	Tryparedoxin peroxidase.	0.579
HSP83-2	TRYP4	Q4Q4I6	Q4QF74	Heat shock protein 83-1.	Tryparedoxin peroxidase.	0.579
HSP83-2	TRYP7	Q4Q4I6	Q4QF68	Heat shock protein 83-1.	Thiol specific antioxidant.	0.577
LMJF_08_1230	HSP83-2	Q4QI42	Q4Q4I6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Heat shock protein 83-1.	0.562
LMJF_08_1230	LMJF_21_1860	Q4QI42	Q4QBZ6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.900
LMJF_08_1230	LMJF_33_0792	Q4QI42	Q4Q4C4	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.900
LMJF_21_1860	HSP83-2	Q4QBZ6	Q4Q4I6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Heat shock protein 83-1.	0.562
LMJF_21_1860	LMJF_08_1230	Q4QBZ6	Q4QI42	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.900
LMJF_21_1860	LMJF_33_0792	Q4QBZ6	Q4Q4C4	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.900
LMJF_23_0040	HSP83-2	Q4QBH2	Q4Q4I6	Peroxidoxin.	Heat shock protein 83-1.	0.424
LMJF_23_0040	TRYR	Q4QBH2	Q4QJG7	Peroxidoxin.	Trypanothione reductase.	0.561
LMJF_23_0040	TXN1	Q4QBH2	E9ADX4	Peroxidoxin.	Tryparedoxin.	0.661
LMJF_23_0040	TXN2	Q4QBH2	E9ADX3	Peroxidoxin.	Tryparedoxin.	0.663
LMJF_33_0792	HSP83-2	Q4Q4C4	Q4Q4I6	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Heat shock protein 83-1.	0.562
LMJF_33_0792	LMJF_08_1230	Q4Q4C4	Q4QI42	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.	0.900