(27 nodes) Tricarboxylic acid cycle network (Fusarium venenatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2L2SS13	Uncharacterized protein. (188 aa)
	A0A2L2SS66	Lipoyl-binding domain-containing protein. (421 aa)
	A0A2L2SSI1	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (787 aa)
	A0A2L2SSS7	Uncharacterized protein. (475 aa)
	A0A2L2SW44	Ligase_CoA domain-containing protein. (342 aa)
	A0A2L2SW88	Uncharacterized protein. (529 aa)
	A0A2L2SWW5	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (381 aa)
	A0A2L2SY58	Uncharacterized protein. (698 aa)
	A0A2L2T0L0	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (650 aa)
	A0A2L2T527	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (329 aa)
	A0A2L2T8V2	Citrate synthase; Belongs to the citrate synthase family. (496 aa)
	A0A2L2TB58	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (463 aa)
	A0A2L2TDT2	Transket_pyr domain-containing protein. (151 aa)
	A0A2L2TE06	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (378 aa)
	A0A2L2TES0	CoA_binding domain-containing protein. (359 aa)
	A0A2L2TEY7	Uncharacterized protein. (489 aa)
	A0A2L2TGB1	FAD_binding_2 domain-containing protein. (531 aa)
	A0A2L2TIL3	FAD_binding_2 domain-containing protein. (507 aa)
	A0A2L2TJI8	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (445 aa)
	A0A2L2TK81	Uncharacterized protein. (188 aa)
	A0A2L2TP54	Lipoyl-binding domain-containing protein. (439 aa)
	A0A2L2TPB1	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (787 aa)
	A0A2L2TQ98	Transket_pyr domain-containing protein. (1051 aa)
	A0A2L2TQJ9	Uncharacterized protein. (336 aa)
	A0A2L2TR69	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (278 aa)
	A0A2L2TVK7	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit. (182 aa)
	A0A2L2U3T5	CoA_binding domain-containing protein. (655 aa)

Your Current Organism:

Fusarium venenatum

NCBI taxonomy Id: 56646
Other names: CBS 458.93, F. venenatum, Fusarium venetum

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2L2SS13	A0A2L2SS66	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.524
A0A2L2SS13	A0A2L2SSI1	Uncharacterized protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.413
A0A2L2SS13	A0A2L2SSS7	Uncharacterized protein.	Uncharacterized protein.	0.886
A0A2L2SS13	A0A2L2SW44	Uncharacterized protein.	Ligase_CoA domain-containing protein.	0.931
A0A2L2SS13	A0A2L2SW88	Uncharacterized protein.	Uncharacterized protein.	0.886
A0A2L2SS13	A0A2L2T0L0	Uncharacterized protein.	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).	0.998
A0A2L2SS13	A0A2L2T527	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.938
A0A2L2SS13	A0A2L2T8V2	Uncharacterized protein.	Citrate synthase; Belongs to the citrate synthase family.	0.738
A0A2L2SS13	A0A2L2TB58	Uncharacterized protein.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.499
A0A2L2SS13	A0A2L2TDT2	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.845
A0A2L2SS13	A0A2L2TES0	Uncharacterized protein.	CoA_binding domain-containing protein.	0.937
A0A2L2SS13	A0A2L2TEY7	Uncharacterized protein.	Uncharacterized protein.	0.882
A0A2L2SS13	A0A2L2TGB1	Uncharacterized protein.	FAD_binding_2 domain-containing protein.	0.940
A0A2L2SS13	A0A2L2TIL3	Uncharacterized protein.	FAD_binding_2 domain-containing protein.	0.940
A0A2L2SS13	A0A2L2TJI8	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.931
A0A2L2SS13	A0A2L2TK81	Uncharacterized protein.	Uncharacterized protein.	0.929
A0A2L2SS13	A0A2L2TP54	Uncharacterized protein.	Lipoyl-binding domain-containing protein.	0.524
A0A2L2SS13	A0A2L2TPB1	Uncharacterized protein.	Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family.	0.413
A0A2L2SS13	A0A2L2TQ98	Uncharacterized protein.	Transket_pyr domain-containing protein.	0.845
A0A2L2SS13	A0A2L2TQJ9	Uncharacterized protein.	Uncharacterized protein.	0.499