(70 nodes) Actin cytoskeleton, and Microtubule-based movement network (Fusarium venenatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2L2SMW0	Uncharacterized protein. (353 aa)
	A0A2L2SND3	Uncharacterized protein. (1200 aa)
	A0A2L2SR31	Uncharacterized protein. (741 aa)
	A0A2L2SR73	Uncharacterized protein. (891 aa)
	A0A2L2SRN8	Uncharacterized protein. (511 aa)
	A0A2L2STH4	Uncharacterized protein. (194 aa)
	A0A2L2STV6	Robl_LC7 domain-containing protein. (136 aa)
	A0A2L2SU92	Calponin-homology (CH) domain-containing protein. (674 aa)
	A0A2L2SUK8	Uncharacterized protein. (656 aa)
	A0A2L2SUL0	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	A0A2L2SW04	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (273 aa)
	A0A2L2SW39	Uncharacterized protein. (610 aa)
	A0A2L2SXB2	Uncharacterized protein. (542 aa)
	A0A2L2SXV0	CS domain-containing protein. (188 aa)
	A0A2L2SYK6	NUDE_C domain-containing protein. (577 aa)
	A0A2L2T0P6	Uncharacterized protein. (693 aa)
	A0A2L2T105	Uncharacterized protein; Belongs to the actin family. (555 aa)
	A0A2L2T1A7	SET domain-containing protein. (750 aa)
	A0A2L2T1P7	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (202 aa)
	A0A2L2T1R1	Amino_oxidase domain-containing protein. (733 aa)
	A0A2L2T1Z9	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (323 aa)
	A0A2L2T331	Uncharacterized protein. (832 aa)
	A0A2L2T3P7	C2H2-type domain-containing protein. (629 aa)
	A0A2L2T3U7	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (192 aa)
	A0A2L2T512	Uncharacterized protein. (353 aa)
	A0A2L2T560	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (139 aa)
	A0A2L2T584	BAR domain-containing protein. (261 aa)
	A0A2L2T5D3	SH3 domain-containing protein. (401 aa)
	A0A2L2T670	Uncharacterized protein. (1126 aa)
	A0A2L2T7F7	Uncharacterized protein. (367 aa)
	A0A2L2T7K1	Uncharacterized protein. (161 aa)
	A0A2L2T7V8	Uncharacterized protein. (434 aa)
	A0A2L2T856	ADF-H domain-containing protein. (142 aa)
	A0A2L2T8M3	Uncharacterized protein. (229 aa)
	A0A2L2T9L3	Uncharacterized protein. (265 aa)
	A0A2L2TAE4	WD_REPEATS_REGION domain-containing protein. (610 aa)
	A0A2L2TAQ3	Uncharacterized protein. (553 aa)
	A0A2L2TDY0	Uncharacterized protein. (332 aa)
	A0A2L2TF17	SH3 domain-containing protein. (1255 aa)
	A0A2L2TFC5	Uncharacterized protein. (649 aa)
	A0A2L2TFT7	Uncharacterized protein. (4347 aa)
	A0A2L2TG86	Uncharacterized protein. (618 aa)
	A0A2L2TGG4	CAP-Gly domain-containing protein. (1343 aa)
	A0A2L2THK4	Uncharacterized protein. (324 aa)
	A0A2L2TI71	Zn(2)-C6 fungal-type domain-containing protein. (558 aa)
	A0A2L2TIN5	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (131 aa)
	A0A2L2TK16	DH domain-containing protein. (2000 aa)
	A0A2L2TKJ1	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (282 aa)
	A0A2L2TKM3	Uncharacterized protein. (424 aa)
	A0A2L2TL82	Uncharacterized protein. (108 aa)
	A0A2L2TN00	Uncharacterized protein. (372 aa)
	A0A2L2TNM5	Uncharacterized protein; Belongs to the actin family. (380 aa)
	A0A2L2TNU5	ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (136 aa)
	A0A2L2TQP9	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (390 aa)
	A0A2L2TRU8	Uncharacterized protein. (507 aa)
	A0A2L2TTI7	Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. (103 aa)
	A0A2L2TU96	Urease; In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (837 aa)
	A0A2L2TUI3	ANK_REP_REGION domain-containing protein. (191 aa)
	A0A2L2TV95	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (363 aa)
	SLX4	Structure-specific endonuclease subunit SLX4; Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (885 aa)
	A0A2L2TW56	Uncharacterized protein. (860 aa)
	A0A2L2TW78	WH2 domain-containing protein. (418 aa)
	A0A2L2TY33	Adenylyl cyclase-associated protein; Belongs to the CAP family. (565 aa)
	A0A2L2U0J8	Uncharacterized protein. (737 aa)
	A0A2L2U0Y4	Uncharacterized protein. (395 aa)
	PAC1	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs. (463 aa)
	A0A2L2U2C3	Uncharacterized protein. (399 aa)
	A0A2L2U2P7	DUF2013 domain-containing protein. (499 aa)
	A0A2L2U300	Uncharacterized protein; Belongs to the actin family. (439 aa)
	A0A2L2U4P1	UNC45-central domain-containing protein. (700 aa)

Your Current Organism:

Fusarium venenatum

NCBI taxonomy Id: 56646
Other names: CBS 458.93, F. venenatum, Fusarium venetum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A2L2SMW0	A0A2L2TN00	A0A2L2SMW0	A0A2L2TN00	Uncharacterized protein.	Uncharacterized protein.	0.606
A0A2L2SMW0	A0A2L2U2C3	A0A2L2SMW0	A0A2L2U2C3	Uncharacterized protein.	Uncharacterized protein.	0.606
A0A2L2SND3	A0A2L2SW04	A0A2L2SND3	A0A2L2SW04	Uncharacterized protein.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.819
A0A2L2SND3	A0A2L2T3P7	A0A2L2SND3	A0A2L2T3P7	Uncharacterized protein.	C2H2-type domain-containing protein.	0.819
A0A2L2SND3	A0A2L2T512	A0A2L2SND3	A0A2L2T512	Uncharacterized protein.	Uncharacterized protein.	0.819
A0A2L2SND3	A0A2L2T9L3	A0A2L2SND3	A0A2L2T9L3	Uncharacterized protein.	Uncharacterized protein.	0.819
A0A2L2SND3	A0A2L2TG86	A0A2L2SND3	A0A2L2TG86	Uncharacterized protein.	Uncharacterized protein.	0.819
A0A2L2SND3	A0A2L2TI71	A0A2L2SND3	A0A2L2TI71	Uncharacterized protein.	Zn(2)-C6 fungal-type domain-containing protein.	0.819
A0A2L2SND3	A0A2L2TKJ1	A0A2L2SND3	A0A2L2TKJ1	Uncharacterized protein.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.967
A0A2L2SR31	A0A2L2SR73	A0A2L2SR31	A0A2L2SR73	Uncharacterized protein.	Uncharacterized protein.	0.699
A0A2L2SR31	A0A2L2SRN8	A0A2L2SR31	A0A2L2SRN8	Uncharacterized protein.	Uncharacterized protein.	0.770
A0A2L2SR31	A0A2L2STH4	A0A2L2SR31	A0A2L2STH4	Uncharacterized protein.	Uncharacterized protein.	0.832
A0A2L2SR31	A0A2L2SU92	A0A2L2SR31	A0A2L2SU92	Uncharacterized protein.	Calponin-homology (CH) domain-containing protein.	0.772
A0A2L2SR31	A0A2L2SUK8	A0A2L2SR31	A0A2L2SUK8	Uncharacterized protein.	Uncharacterized protein.	0.750
A0A2L2SR31	A0A2L2SUL0	A0A2L2SR31	A0A2L2SUL0	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.750
A0A2L2SR31	A0A2L2SW04	A0A2L2SR31	A0A2L2SW04	Uncharacterized protein.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.669
A0A2L2SR31	A0A2L2SW39	A0A2L2SR31	A0A2L2SW39	Uncharacterized protein.	Uncharacterized protein.	0.802
A0A2L2SR31	A0A2L2SXB2	A0A2L2SR31	A0A2L2SXB2	Uncharacterized protein.	Uncharacterized protein.	0.695
A0A2L2SR31	A0A2L2T0P6	A0A2L2SR31	A0A2L2T0P6	Uncharacterized protein.	Uncharacterized protein.	0.727
A0A2L2SR31	A0A2L2T1P7	A0A2L2SR31	A0A2L2T1P7	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.832