(14 nodes) Mixed, incl. Sensing of DNA Double Strand Breaks, and Checkpoint clamp complex network (Fusarium venenatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2L2STJ5	FHA domain-containing protein. (846 aa)
	A0A2L2SW81	Uncharacterized protein. (739 aa)
	A0A2L2SX15	Uncharacterized protein. (1565 aa)
	A0A2L2T3R4	AAA_23 domain-containing protein. (1307 aa)
	A0A2L2T6Y6	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2494 aa)
	A0A2L2TB08	ANK_REP_REGION domain-containing protein. (72 aa)
	A0A2L2TG87	Checkpoint protein; Belongs to the HUS1 family. (343 aa)
	A0A2L2TH12	Uncharacterized protein. (860 aa)
	A0A2L2TQG0	Uncharacterized protein. (791 aa)
	A0A2L2TQQ8	Uncharacterized protein. (1595 aa)
	A0A2L2TS93	Uncharacterized protein. (471 aa)
	A0A2L2TSC0	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (464 aa)
	A0A2L2TVE3	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (719 aa)
	A0A2L2U0S4	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2949 aa)

Your Current Organism:

Fusarium venenatum

NCBI taxonomy Id: 56646
Other names: CBS 458.93, F. venenatum, Fusarium venetum

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2L2STJ5	A0A2L2SW81	FHA domain-containing protein.	Uncharacterized protein.	0.743
A0A2L2STJ5	A0A2L2SX15	FHA domain-containing protein.	Uncharacterized protein.	0.788
A0A2L2STJ5	A0A2L2T3R4	FHA domain-containing protein.	AAA_23 domain-containing protein.	0.994
A0A2L2STJ5	A0A2L2T6Y6	FHA domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.970
A0A2L2STJ5	A0A2L2TB08	FHA domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.975
A0A2L2STJ5	A0A2L2TG87	FHA domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.781
A0A2L2STJ5	A0A2L2TH12	FHA domain-containing protein.	Uncharacterized protein.	0.836
A0A2L2STJ5	A0A2L2TQG0	FHA domain-containing protein.	Uncharacterized protein.	0.815
A0A2L2STJ5	A0A2L2TQQ8	FHA domain-containing protein.	Uncharacterized protein.	0.699
A0A2L2STJ5	A0A2L2TS93	FHA domain-containing protein.	Uncharacterized protein.	0.720
A0A2L2STJ5	A0A2L2TSC0	FHA domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.784
A0A2L2STJ5	A0A2L2TVE3	FHA domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.998
A0A2L2STJ5	A0A2L2U0S4	FHA domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.992
A0A2L2SW81	A0A2L2STJ5	Uncharacterized protein.	FHA domain-containing protein.	0.743
A0A2L2SW81	A0A2L2SX15	Uncharacterized protein.	Uncharacterized protein.	0.903
A0A2L2SW81	A0A2L2T3R4	Uncharacterized protein.	AAA_23 domain-containing protein.	0.851
A0A2L2SW81	A0A2L2T6Y6	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.925
A0A2L2SW81	A0A2L2TB08	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.773
A0A2L2SW81	A0A2L2TG87	Uncharacterized protein.	Checkpoint protein; Belongs to the HUS1 family.	0.779
A0A2L2SW81	A0A2L2TH12	Uncharacterized protein.	Uncharacterized protein.	0.847