(30 nodes) Cortical actin cytoskeleton organization network (Fusarium venenatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2L2SR73	Uncharacterized protein. (891 aa)
	A0A2L2SRB1	Uncharacterized protein. (375 aa)
	A0A2L2STK5	Uncharacterized protein. (1304 aa)
	A0A2L2SUK8	Uncharacterized protein. (656 aa)
	A0A2L2SUL0	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (169 aa)
	A0A2L2SWZ3	Uncharacterized protein. (1054 aa)
	A0A2L2T1P7	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (202 aa)
	A0A2L2T1Z9	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (323 aa)
	A0A2L2T3U7	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (192 aa)
	A0A2L2T670	Uncharacterized protein. (1126 aa)
	A0A2L2T6J6	Uncharacterized protein. (161 aa)
	A0A2L2T7V8	Uncharacterized protein. (434 aa)
	A0A2L2T8K9	TYR_PHOSPHATASE_2 domain-containing protein. (634 aa)
	A0A2L2T9N8	Uncharacterized protein. (332 aa)
	A0A2L2TBX7	Protein kinase domain-containing protein. (1017 aa)
	A0A2L2TC17	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1683 aa)
	A0A2L2TD69	Uncharacterized protein. (143 aa)
	A0A2L2TDB4	Uncharacterized protein. (1755 aa)
	A0A2L2TIN5	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. (131 aa)
	A0A2L2TL05	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1221 aa)
	A0A2L2TL93	Uncharacterized protein. (270 aa)
	A0A2L2TNM0	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2398 aa)
	A0A2L2TQP9	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (390 aa)
	A0A2L2TUK1	Uncharacterized protein. (791 aa)
	A0A2L2TV95	Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks; Belongs to the WD repeat ARPC1 family. (363 aa)
	A0A2L2TX57	CRIB domain-containing protein. (810 aa)
	A0A2L2U0Y4	Uncharacterized protein. (395 aa)
	A0A2L2U200	MHD domain-containing protein. (886 aa)
	A0A2L2U2P7	DUF2013 domain-containing protein. (499 aa)
	A0A2L2U300	Uncharacterized protein; Belongs to the actin family. (439 aa)

Your Current Organism:

Fusarium venenatum

NCBI taxonomy Id: 56646
Other names: CBS 458.93, F. venenatum, Fusarium venetum

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2L2SR73	A0A2L2SRB1	Uncharacterized protein.	Uncharacterized protein.	0.897
A0A2L2SR73	A0A2L2STK5	Uncharacterized protein.	Uncharacterized protein.	0.493
A0A2L2SR73	A0A2L2T670	Uncharacterized protein.	Uncharacterized protein.	0.699
A0A2L2SR73	A0A2L2T6J6	Uncharacterized protein.	Uncharacterized protein.	0.877
A0A2L2SR73	A0A2L2TIN5	Uncharacterized protein.	Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.	0.409
A0A2L2SR73	A0A2L2TL93	Uncharacterized protein.	Uncharacterized protein.	0.621
A0A2L2SR73	A0A2L2TNM0	Uncharacterized protein.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.873
A0A2L2SR73	A0A2L2TQP9	Uncharacterized protein.	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament.	0.720
A0A2L2SR73	A0A2L2TUK1	Uncharacterized protein.	Uncharacterized protein.	0.706
A0A2L2SR73	A0A2L2U300	Uncharacterized protein.	Uncharacterized protein; Belongs to the actin family.	0.696
A0A2L2SRB1	A0A2L2SR73	Uncharacterized protein.	Uncharacterized protein.	0.897
A0A2L2SRB1	A0A2L2STK5	Uncharacterized protein.	Uncharacterized protein.	0.757
A0A2L2SRB1	A0A2L2SUK8	Uncharacterized protein.	Uncharacterized protein.	0.879
A0A2L2SRB1	A0A2L2SUL0	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.	0.919
A0A2L2SRB1	A0A2L2SWZ3	Uncharacterized protein.	Uncharacterized protein.	0.747
A0A2L2SRB1	A0A2L2T1P7	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.	0.929
A0A2L2SRB1	A0A2L2T1Z9	Uncharacterized protein.	Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.960
A0A2L2SRB1	A0A2L2T3U7	Uncharacterized protein.	Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.	0.968
A0A2L2SRB1	A0A2L2T670	Uncharacterized protein.	Uncharacterized protein.	0.443
A0A2L2SRB1	A0A2L2T6J6	Uncharacterized protein.	Uncharacterized protein.	0.973