(53 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Fusarium venenatum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A2L2U1C3	Uncharacterized protein. (266 aa)
	A0A2L2TW04	Uncharacterized protein. (577 aa)
	A0A2L2TUV5	4-hydroxyphenylpyruvate dioxygenase. (424 aa)
	A0A2L2TUR2	Uncharacterized protein. (237 aa)
	A0A2L2TU39	Methyltransf_11 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family. (330 aa)
	A0A2L2TSG1	AP_endonuc_2 domain-containing protein. (351 aa)
	A0A2L2TQR5	AB hydrolase-1 domain-containing protein. (281 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (242 aa)
	A0A2L2TNI8	Uncharacterized protein. (575 aa)
	A0A2L2TJW2	Uncharacterized protein. (556 aa)
	A0A2L2TJB1	Uncharacterized protein. (553 aa)
	A0A2L2TJ05	AB hydrolase-1 domain-containing protein. (534 aa)
	A0A2L2TJ00	MR_MLE domain-containing protein. (360 aa)
	A0A2L2THT2	Uncharacterized protein. (680 aa)
	COQ5	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). (307 aa)
	A0A2L2TGB7	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (404 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (487 aa)
	A0A2L2TE37	Uncharacterized protein. (580 aa)
	A0A2L2TDI7	Uncharacterized protein. (576 aa)
	FDC1-3	Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily. (530 aa)
	PAD1-2	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (191 aa)
	FDC1-2	Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily. (503 aa)
	A0A2L2TC75	Uncharacterized protein. (528 aa)
	A0A2L2TBV4	4HBT domain-containing protein. (179 aa)
	A0A2L2TBH6	Uncharacterized protein. (227 aa)
	A0A2L2TB78	Uncharacterized protein. (568 aa)
	A0A2L2TAR9	Aminotran_1_2 domain-containing protein. (559 aa)
	A0A2L2TAJ9	4HBT domain-containing protein. (170 aa)
	A0A2L2T8S9	3-dmu-9_3-mt domain-containing protein. (161 aa)
	A0A2L2T810	Uncharacterized protein. (574 aa)
	A0A2L2T7G5	AB hydrolase-1 domain-containing protein. (284 aa)
	A0A2L2T719	Uncharacterized protein. (532 aa)
	A0A2L2T6T9	Uncharacterized protein. (157 aa)
	A0A2L2T695	Flavodoxin-like domain-containing protein. (252 aa)
	A0A2L2T3K9	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa)
	PAD1	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (257 aa)
	A0A2L2T2Y9	Uncharacterized protein. (510 aa)
	A0A2L2SZP5	AP_endonuc_2 domain-containing protein. (340 aa)
	A0A2L2SZM8	Uncharacterized protein. (1230 aa)
	A0A2L2SZF4	Uncharacterized protein. (573 aa)
	A0A2L2SYS5	Aminotran_1_2 domain-containing protein. (398 aa)
	A0A2L2SYQ0	FAD_binding_3 domain-containing protein. (600 aa)
	A0A2L2SYB0	Uncharacterized protein. (361 aa)
	A0A2L2SX18	Uncharacterized protein. (254 aa)
	COQ3	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. (304 aa)
	A0A2L2ST14	Aminotran_1_2 domain-containing protein. (371 aa)
	FDC1	Ferulic acid decarboxylase 1; Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4- vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites; Belongs to the UbiD family. UbiD-like/FDC subfamily. (506 aa)
	A0A2L2SSW6	Carrier domain-containing protein. (1649 aa)
	A0A2L2SRL2	Uncharacterized protein. (1296 aa)
	A0A2L2SR11	Aminotran_1_2 domain-containing protein. (649 aa)
	A0A2L2SQR9	Uncharacterized protein. (384 aa)
	A0A2L2SPC8	Uncharacterized protein. (614 aa)
	A0A2L2SP79	AB hydrolase-1 domain-containing protein. (264 aa)

Your Current Organism:

Fusarium venenatum

NCBI taxonomy Id: 56646
Other names: CBS 458.93, F. venenatum, Fusarium venetum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A2L2SP79	A0A2L2SZM8	A0A2L2SP79	A0A2L2SZM8	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.493
A0A2L2SQR9	A0A2L2SX18	A0A2L2SQR9	A0A2L2SX18	Uncharacterized protein.	Uncharacterized protein.	0.549
A0A2L2SQR9	A0A2L2T2Y9	A0A2L2SQR9	A0A2L2T2Y9	Uncharacterized protein.	Uncharacterized protein.	0.549
A0A2L2SQR9	A0A2L2T6T9	A0A2L2SQR9	A0A2L2T6T9	Uncharacterized protein.	Uncharacterized protein.	0.452
A0A2L2SQR9	A0A2L2T719	A0A2L2SQR9	A0A2L2T719	Uncharacterized protein.	Uncharacterized protein.	0.549
A0A2L2SQR9	A0A2L2TBH6	A0A2L2SQR9	A0A2L2TBH6	Uncharacterized protein.	Uncharacterized protein.	0.549
A0A2L2SQR9	A0A2L2TC75	A0A2L2SQR9	A0A2L2TC75	Uncharacterized protein.	Uncharacterized protein.	0.549
A0A2L2SQR9	A0A2L2TGB7	A0A2L2SQR9	A0A2L2TGB7	Uncharacterized protein.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.528
A0A2L2SQR9	A0A2L2TUR2	A0A2L2SQR9	A0A2L2TUR2	Uncharacterized protein.	Uncharacterized protein.	0.549
A0A2L2SQR9	COQ3	A0A2L2SQR9	A0A2L2SVN9	Uncharacterized protein.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.	0.549
A0A2L2SQR9	COQ5	A0A2L2SQR9	A0A2L2TH20	Uncharacterized protein.	2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2).	0.611
A0A2L2SQR9	PAD1	A0A2L2SQR9	A0A2L2T3K5	Uncharacterized protein.	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.	0.422
A0A2L2SQR9	PAD1-2	A0A2L2SQR9	A0A2L2TCX6	Uncharacterized protein.	Flavin prenyltransferase PAD1, mitochondrial; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.	0.422
A0A2L2SR11	A0A2L2SYS5	A0A2L2SR11	A0A2L2SYS5	Aminotran_1_2 domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.494
A0A2L2SR11	A0A2L2SZP5	A0A2L2SR11	A0A2L2SZP5	Aminotran_1_2 domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.579
A0A2L2SR11	A0A2L2T7G5	A0A2L2SR11	A0A2L2T7G5	Aminotran_1_2 domain-containing protein.	AB hydrolase-1 domain-containing protein.	0.783
A0A2L2SR11	A0A2L2TJ00	A0A2L2SR11	A0A2L2TJ00	Aminotran_1_2 domain-containing protein.	MR_MLE domain-containing protein.	0.783
A0A2L2SR11	A0A2L2TQR5	A0A2L2SR11	A0A2L2TQR5	Aminotran_1_2 domain-containing protein.	AB hydrolase-1 domain-containing protein.	0.783
A0A2L2SR11	A0A2L2TSG1	A0A2L2SR11	A0A2L2TSG1	Aminotran_1_2 domain-containing protein.	AP_endonuc_2 domain-containing protein.	0.579
A0A2L2SR11	A0A2L2TUV5	A0A2L2SR11	A0A2L2TUV5	Aminotran_1_2 domain-containing protein.	4-hydroxyphenylpyruvate dioxygenase.	0.770