STRINGSTRING
LINJ_35_1320 LINJ_35_1320 LINJ_19_0040 LINJ_19_0040 LINJ_02_0100 LINJ_02_0100 LINJ_05_0430 LINJ_05_0430 LINJ_05_0710 LINJ_05_0710 LINJ_06_0010 LINJ_06_0010 LINJ_06_0280 LINJ_06_0280 LINJ_09_1410 LINJ_09_1410 LINJ_10_0320 LINJ_10_0320 LINJ_11_0230 LINJ_11_0230 LINJ_13_1570 LINJ_13_1570 LINJ_14_1350 LINJ_14_1350 LINJ_15_0010 LINJ_15_0010 LINJ_16_0330 LINJ_16_0330 LINJ_17_0070 LINJ_17_0070 LINJ_17_1320 LINJ_17_1320 LINJ_19_0030 LINJ_19_0030 LINJ_19_1510 LINJ_19_1510 LINJ_20_0070 LINJ_20_0070 LINJ_21_0180 LINJ_21_0180 LINJ_36_0660 LINJ_36_0660 LINJ_23_0100 LINJ_23_0100 LINJ_24_1580 LINJ_24_1580 LINJ_24_1590 LINJ_24_1590 CYC11 CYC11 CYC10 CYC10 LinJ25.1380 LinJ25.1380 LINJ_26_1320 LINJ_26_1320 LINJ_26_1330 LINJ_26_1330 FEN1 FEN1 LINJ_27_1790 LINJ_27_1790 LINJ_28_0210 LINJ_28_0210 LINJ_28_0560 LINJ_28_0560 RAD51 RAD51 LINJ_28_1530 LINJ_28_1530 LINJ_28_1540 LINJ_28_1540 LINJ_28_1550 LINJ_28_1550 RPA1 RPA1 LINJ_28_2870 LINJ_28_2870 LINJ_29_0460 LINJ_29_0460 LINJ_29_1910 LINJ_29_1910 LINJ_30_0340 LINJ_30_0340 LINJ_30_2300 LINJ_30_2300 CYC7 CYC7 LINJ_31_2780 LINJ_31_2780 CYC2 CYC2 LINJ_32_1520 LINJ_32_1520 LINJ_32_3230 LINJ_32_3230 CYC5 CYC5 LINJ_36_3350 LINJ_36_3350 TDBP1 TDBP1 LINJ_34_1340 LINJ_34_1340 LINJ_34_2110 LINJ_34_2110 LINJ_34_3980 LINJ_34_3980 LINJ_34_4070 LINJ_34_4070
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LINJ_35_1320Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
LINJ_19_0040Histone H2B; Belongs to the histone H2B family. (107 aa)
LINJ_02_0100Putative phosphatidylinositol kinase related protein; Belongs to the PI3/PI4-kinase family. (4906 aa)
LINJ_05_0430Uncharacterized protein. (675 aa)
LINJ_05_0710Putative CYC2-like cyclin. (1400 aa)
LINJ_06_0010Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
LINJ_06_0280Uncharacterized protein. (855 aa)
LINJ_09_1410Histone H2B; Belongs to the histone H2B family. (111 aa)
LINJ_10_0320Uncharacterized protein. (765 aa)
LINJ_11_0230Uncharacterized protein. (518 aa)
LINJ_13_1570Putative phosphoprotein phosphatase. (433 aa)
LINJ_14_1350Putative ubiquitin/ribosomal protein S27a. (152 aa)
LINJ_15_0010Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (100 aa)
LINJ_16_0330Uncharacterized protein. (1270 aa)
LINJ_17_0070Putative mitogen-activated protein kinase kinase 3. (553 aa)
LINJ_17_1320Histone H2B; Belongs to the histone H2B family. (111 aa)
LINJ_19_0030Histone H2B; Belongs to the histone H2B family. (135 aa)
LINJ_19_1510Uncharacterized protein. (621 aa)
LINJ_20_0070Uncharacterized protein. (1165 aa)
LINJ_21_0180DNA topoisomerase 1A. (809 aa)
LINJ_36_0660Putative ubiquitin/ribosomal protein S27a. (152 aa)
LINJ_23_0100Uncharacterized protein. (346 aa)
LINJ_24_1580Uncharacterized protein. (1151 aa)
LINJ_24_1590Putative ATP-dependent DEAD/H DNA helicase recQ. (1946 aa)
CYC11Putative cyclin 11. (933 aa)
CYC10Cyclin 10. (658 aa)
LinJ25.1380Structure-specific endonuclease subunit SLX1 homolog; Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA; Belongs to the SLX1 family. (705 aa)
LINJ_26_1320Putative DNA ligase k alpha. (630 aa)
LINJ_26_1330Putative DNA ligase. (433 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (395 aa)
LINJ_27_1790Putative endo/exonuclease Mre11. (858 aa)
LINJ_28_0210Histone H2B; Belongs to the histone H2B family. (142 aa)
LINJ_28_0560RAD50 DNA repair-like protein. (1360 aa)
RAD51DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (376 aa)
LINJ_28_1530Putative DNA polymerase kappa. (753 aa)
LINJ_28_1540Putative DNA polymerase kappa. (598 aa)
LINJ_28_1550Putative DNA polymerase kappa. (409 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (467 aa)
LINJ_28_2870Serine/threonine-protein phosphatase. (307 aa)
LINJ_29_0460Uncharacterized protein. (649 aa)
LINJ_29_1910Uncharacterized protein. (1174 aa)
LINJ_30_0340Putative KU80 protein. (798 aa)
LINJ_30_2300ATP-dependent DEAD/H DNA helicase recQ family-like protein. (1003 aa)
CYC7Putative CYC2-like protein. (253 aa)
LINJ_31_2780Uncharacterized protein. (891 aa)
CYC2Cyclin; Belongs to the cyclin family. (164 aa)
LINJ_32_1520Putative phosphatidylinositol 3-related kinase; Belongs to the PI3/PI4-kinase family. (3211 aa)
LINJ_32_3230Serine/threonine-protein phosphatase. (308 aa)
CYC5Putative CYC2-like cyclin. (881 aa)
LINJ_36_3350DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (947 aa)
TDBP1Tyrosyl-DNA phosphodiesterase 1. (682 aa)
LINJ_34_1340Uncharacterized protein. (548 aa)
LINJ_34_2110Putative asparaginyl-tRNA synthetase. (890 aa)
LINJ_34_3980Uncharacterized protein. (658 aa)
LINJ_34_4070Uncharacterized protein. (410 aa)
Your Current Organism:
Leishmania infantum
NCBI taxonomy Id: 5671
Other names: L. infantum, Leishmania (Leishmania) infantum, Leishmania donovani infantum
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