(22 nodes) PTEN Regulation network (Leishmania infantum)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	LinJ34.0590	Translation factor GUF1 homolog, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (834 aa)
	LINJ_35_1720	Putative casein kinase II; Belongs to the protein kinase superfamily. (372 aa)
	LINJ_35_3880	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (254 aa)
	LINJ_36_0660	Putative ubiquitin/ribosomal protein S27a. (152 aa)
	LINJ_36_1670	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (264 aa)
	LINJ_36_1730	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (302 aa)
	LINJ_36_5320	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (275 aa)
	LINJ_25_0620	Uncharacterized protein. (1470 aa)
	LINJ_25_0130	Putative elongation factor. (634 aa)
	LINJ_20_1280	Uncharacterized protein. (2757 aa)
	LINJ_19_0980	Uncharacterized protein. (811 aa)
	LINJ_14_1350	Putative ubiquitin/ribosomal protein S27a. (152 aa)
	LINJ.12.0003	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family. (283 aa)
	LINJ_11_0240	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family. (247 aa)
	LINJ_07_1090	Uncharacterized protein. (2448 aa)
	LINJ_02_0330	Putative casein kinase II, alpha chain; Belongs to the protein kinase superfamily. (381 aa)
	LINJ_36_6140	Putative ras-like small GTPases. (364 aa)
	LINJ_25_2450	Putative serine/threonine-protein kinase; Belongs to the protein kinase superfamily. (389 aa)
	LINJ_26_1640	Uncharacterized protein. (328 aa)
	LINJ_28_1800	Zinc finger protein kinase-like. (1323 aa)
	LINJ_28_1850	Putative proteasome regulatory non-ATP-ase subunit 2; Belongs to the proteasome subunit S1 family. (991 aa)
	LINJ_31_2920	Uncharacterized protein. (270 aa)

Your Current Organism:

Leishmania infantum

NCBI taxonomy Id: 5671
Other names: L. infantum, Leishmania (Leishmania) infantum, Leishmania donovani infantum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LINJ.12.0003	LINJ_07_1090	A4HV47	A4HTB8	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Uncharacterized protein.	0.995
LINJ.12.0003	LINJ_11_0240	A4HV47	A4HUT6	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
LINJ.12.0003	LINJ_14_1350	A4HV47	A4HW73	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Putative ubiquitin/ribosomal protein S27a.	0.880
LINJ.12.0003	LINJ_28_1850	A4HV47	A4I3Q0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Putative proteasome regulatory non-ATP-ase subunit 2; Belongs to the proteasome subunit S1 family.	0.999
LINJ.12.0003	LINJ_35_3880	A4HV47	A4IBS2	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
LINJ.12.0003	LINJ_36_0660	A4HV47	A4ICS4	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Putative ubiquitin/ribosomal protein S27a.	0.880
LINJ.12.0003	LINJ_36_1670	A4HV47	A4IDD0	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
LINJ.12.0003	LINJ_36_1730	A4HV47	A4IDD6	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999
LINJ_02_0330	LINJ_25_2450	A4HRN3	A4I1T4	Putative casein kinase II, alpha chain; Belongs to the protein kinase superfamily.	Putative serine/threonine-protein kinase; Belongs to the protein kinase superfamily.	0.417
LINJ_02_0330	LINJ_35_1720	A4HRN3	A4IB73	Putative casein kinase II, alpha chain; Belongs to the protein kinase superfamily.	Putative casein kinase II; Belongs to the protein kinase superfamily.	0.905
LINJ_02_0330	LINJ_36_5320	A4HRN3	A4IDT1	Putative casein kinase II, alpha chain; Belongs to the protein kinase superfamily.	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family.	0.982
LINJ_07_1090	LINJ.12.0003	A4HTB8	A4HV47	Uncharacterized protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.995
LINJ_07_1090	LINJ_11_0240	A4HTB8	A4HUT6	Uncharacterized protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.993
LINJ_07_1090	LINJ_14_1350	A4HTB8	A4HW73	Uncharacterized protein.	Putative ubiquitin/ribosomal protein S27a.	0.536
LINJ_07_1090	LINJ_28_1850	A4HTB8	A4I3Q0	Uncharacterized protein.	Putative proteasome regulatory non-ATP-ase subunit 2; Belongs to the proteasome subunit S1 family.	0.750
LINJ_07_1090	LINJ_35_3880	A4HTB8	A4IBS2	Uncharacterized protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.987
LINJ_07_1090	LINJ_36_0660	A4HTB8	A4ICS4	Uncharacterized protein.	Putative ubiquitin/ribosomal protein S27a.	0.536
LINJ_07_1090	LINJ_36_1670	A4HTB8	A4IDD0	Uncharacterized protein.	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	0.999
LINJ_07_1090	LINJ_36_1730	A4HTB8	A4IDD6	Uncharacterized protein.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.994
LINJ_11_0240	LINJ.12.0003	A4HUT6	A4HV47	Proteasome subunit alpha type; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1A family.	Proteasome subunit beta; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH; Belongs to the peptidase T1B family.	0.999