(31 nodes) DNA Damage Bypass network (Leishmania infantum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LINJ_27_2560	Putative replication factor C, subunit 4. (360 aa)
	LINJ_09_1280	Putative AAA family ATPase. (1288 aa)
	LINJ_14_1350	Putative ubiquitin/ribosomal protein S27a. (152 aa)
	LINJ_15_1500	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (293 aa)
	LINJ_20_1110	Uncharacterized protein. (1953 aa)
	LINJ_23_1590	Putative DNA polymerase zeta catalytic subunit. (3085 aa)
	LINJ_24_1010	Putative replication factor C, subunit 1. (660 aa)
	LINJ_25_1310	Uncharacterized protein; Belongs to the cullin family. (1066 aa)
	LINJ_27_0370	Putative ATPase. (656 aa)
	LINJ_28_1530	Putative DNA polymerase kappa. (753 aa)
	LINJ_28_1540	Putative DNA polymerase kappa. (598 aa)
	LINJ_28_1550	Putative DNA polymerase kappa. (409 aa)
	LINJ_28_1580	Putative ATPase. (696 aa)
	LINJ_36_7020	Putative replication factor C, subunit 5. (351 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (467 aa)
	LINJ_28_2260	Uncharacterized protein; Belongs to the cullin family. (766 aa)
	LINJ_30_2520	AAA family ATPase-like protein. (1049 aa)
	LINJ_30_2620	Putative replication factor C, subunit 2. (354 aa)
	LINJ_30_3770	Putative CPSF-domain protein. (1347 aa)
	LINJ_31_1740	Uncharacterized protein; Belongs to the cullin family. (1198 aa)
	LINJ_32_1310	Putative ubiquitin hydrolase; Belongs to the peptidase C19 family. (540 aa)
	LINJ_32_1970	Uncharacterized protein. (158 aa)
	LINJ_34_3980	Uncharacterized protein. (658 aa)
	LINJ_35_1780	Putative DNA polymerase epsilon subunit b. (552 aa)
	LINJ_35_3300	Putative replication factor C, subunit 3. (364 aa)
	LINJ_35_4430	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2224 aa)
	LINJ_36_6780	Putative ubiquitin fusion degradation protein. (325 aa)
	LINJ_36_1420	Putative Transitional endoplasmic reticulum ATPase; Belongs to the AAA ATPase family. (690 aa)
	LINJ_36_0660	Putative ubiquitin/ribosomal protein S27a. (152 aa)
	LINJ_36_0110	Putative DNA damage repair protein. (619 aa)
	LINJ_24_0170	Putative ATPase domain protein. (535 aa)

Your Current Organism:

Leishmania infantum

NCBI taxonomy Id: 5671
Other names: L. infantum, Leishmania (Leishmania) infantum, Leishmania donovani infantum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LINJ_09_1280	LINJ_14_1350	A4HU44	A4HW73	Putative AAA family ATPase.	Putative ubiquitin/ribosomal protein S27a.	0.540
LINJ_09_1280	LINJ_15_1500	A4HU44	A4HWN2	Putative AAA family ATPase.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.518
LINJ_09_1280	LINJ_27_2560	A4HU44	E9AHC5	Putative AAA family ATPase.	Putative replication factor C, subunit 4.	0.469
LINJ_09_1280	LINJ_30_2620	A4HU44	A4I5T9	Putative AAA family ATPase.	Putative replication factor C, subunit 2.	0.469
LINJ_09_1280	LINJ_35_3300	A4HU44	A4IBL6	Putative AAA family ATPase.	Putative replication factor C, subunit 3.	0.470
LINJ_09_1280	LINJ_36_0660	A4HU44	A4ICS4	Putative AAA family ATPase.	Putative ubiquitin/ribosomal protein S27a.	0.540
LINJ_09_1280	LINJ_36_6780	A4HU44	A4ICA6	Putative AAA family ATPase.	Putative ubiquitin fusion degradation protein.	0.850
LINJ_09_1280	LINJ_36_7020	A4HU44	E9AI03	Putative AAA family ATPase.	Putative replication factor C, subunit 5.	0.469
LINJ_14_1350	LINJ_09_1280	A4HW73	A4HU44	Putative ubiquitin/ribosomal protein S27a.	Putative AAA family ATPase.	0.540
LINJ_14_1350	LINJ_15_1500	A4HW73	A4HWN2	Putative ubiquitin/ribosomal protein S27a.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.889
LINJ_14_1350	LINJ_20_1110	A4HW73	A4HYV1	Putative ubiquitin/ribosomal protein S27a.	Uncharacterized protein.	0.515
LINJ_14_1350	LINJ_24_0170	A4HW73	E9AH29	Putative ubiquitin/ribosomal protein S27a.	Putative ATPase domain protein.	0.540
LINJ_14_1350	LINJ_24_1010	A4HW73	A4I0T7	Putative ubiquitin/ribosomal protein S27a.	Putative replication factor C, subunit 1.	0.515
LINJ_14_1350	LINJ_25_1310	A4HW73	A4I1H2	Putative ubiquitin/ribosomal protein S27a.	Uncharacterized protein; Belongs to the cullin family.	0.511
LINJ_14_1350	LINJ_27_0370	A4HW73	A4I2M3	Putative ubiquitin/ribosomal protein S27a.	Putative ATPase.	0.540
LINJ_14_1350	LINJ_27_2560	A4HW73	E9AHC5	Putative ubiquitin/ribosomal protein S27a.	Putative replication factor C, subunit 4.	0.625
LINJ_14_1350	LINJ_28_1530	A4HW73	A4I3M0	Putative ubiquitin/ribosomal protein S27a.	Putative DNA polymerase kappa.	0.536
LINJ_14_1350	LINJ_28_1540	A4HW73	A4I3M1	Putative ubiquitin/ribosomal protein S27a.	Putative DNA polymerase kappa.	0.536
LINJ_14_1350	LINJ_28_1550	A4HW73	A4I3M2	Putative ubiquitin/ribosomal protein S27a.	Putative DNA polymerase kappa.	0.536
LINJ_14_1350	LINJ_28_1580	A4HW73	A4I3M5	Putative ubiquitin/ribosomal protein S27a.	Putative ATPase.	0.540