(47 nodes) Sphingolipid de novo biosynthesis, and Sphingomyelin catabolic process network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gba2	Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (872 aa)
	ENSLBEP00000000833	Uncharacterized protein. (50 aa)
	LOC110002256	Zgc:153896. (436 aa)
	asah1	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (392 aa)
	cers5	Uncharacterized protein. (389 aa)
	sgpp1	acidPPc domain-containing protein. (498 aa)
	sgms1	Zgc:91976. (409 aa)
	cers6	Ceramide synthase 6. (395 aa)
	CERK	Ceramide kinase. (556 aa)
	LOC109987762	Ceramide synthase 4a. (404 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (725 aa)
	ENSLBEP00000011312	Uncharacterized protein. (330 aa)
	LOC109996951	Uncharacterized protein. (444 aa)
	plpp3	Phospholipid phosphatase 3. (313 aa)
	LOC109980968	Ceramide synthase 5. (379 aa)
	LOC109994192	Si:ch211-212g7.6. (438 aa)
	acer3	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (315 aa)
	LOC109991296	Ceramide synthase 3b. (371 aa)
	LOC109995408	acidPPc domain-containing protein. (313 aa)
	LOC109989554	acidPPc domain-containing protein. (293 aa)
	LOC109994819	Zgc:158263. (585 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
	LOC110005037	PAP2_C domain-containing protein. (382 aa)
	ENSLBEP00000017825	Uncharacterized protein. (191 aa)
	cers1	Ceramide synthase 1. (253 aa)
	degs1	Delta(4)-desaturase, sphingolipid 1. (323 aa)
	LOC109991992	Ceramide synthase 4b. (406 aa)
	SGPP2	Sphingosine-1-phosphate phosphatase 2. (377 aa)
	kdsr	3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
	ugcg	UDP-glucose ceramide glucosyltransferase. (394 aa)
	ENSLBEP00000026330	Uncharacterized protein. (220 aa)
	LOC109982310	Ceramide synthase 3a. (396 aa)
	cerkl	Ceramide kinase-like. (419 aa)
	degs2	Delta(4)-desaturase, sphingolipid 2. (322 aa)
	acer2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (295 aa)
	LOC109996162	Phospholipid phosphatase 2a. (286 aa)
	LOC109989226	Phosphatidic acid phosphatase type 2D. (330 aa)
	sgpl1	Sphingosine-1-phosphate lyase 1. (565 aa)
	asah2	Neutral ceramidase. (738 aa)
	smpd2	Sphingomyelin phosphodiesterase 2b, neutral membrane (neutral sphingomyelinase). (412 aa)
	ENSLBEP00000033581	Uncharacterized protein. (377 aa)
	ENSLBEP00000033611	DAGKc domain-containing protein. (248 aa)
	LOC109986498	Ceramide synthase 2b. (384 aa)
	gba	Glucosylceramidase. (526 aa)
	LOC109988676	Ceramide synthase 2a. (382 aa)
	LOC110004136	DAGKc domain-containing protein. (399 aa)
	smpdl3b	Acid sphingomyelinase-like phosphodiesterase. (453 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CERK	ENSLBEP00000000833	ENSLBEP00000006538	ENSLBEP00000000833	Ceramide kinase.	Uncharacterized protein.	0.847
CERK	ENSLBEP00000017825	ENSLBEP00000006538	ENSLBEP00000017825	Ceramide kinase.	Uncharacterized protein.	0.856
CERK	ENSLBEP00000026330	ENSLBEP00000006538	ENSLBEP00000026330	Ceramide kinase.	Uncharacterized protein.	0.870
CERK	LOC109980968	ENSLBEP00000006538	ENSLBEP00000013548	Ceramide kinase.	Ceramide synthase 5.	0.869
CERK	LOC109982310	ENSLBEP00000006538	ENSLBEP00000027159	Ceramide kinase.	Ceramide synthase 3a.	0.857
CERK	LOC109986498	ENSLBEP00000006538	ENSLBEP00000034716	Ceramide kinase.	Ceramide synthase 2b.	0.857
CERK	LOC109987762	ENSLBEP00000006538	ENSLBEP00000006675	Ceramide kinase.	Ceramide synthase 4a.	0.869
CERK	LOC109988676	ENSLBEP00000006538	ENSLBEP00000036001	Ceramide kinase.	Ceramide synthase 2a.	0.869
CERK	LOC109989226	ENSLBEP00000006538	ENSLBEP00000031180	Ceramide kinase.	Phosphatidic acid phosphatase type 2D.	0.442
CERK	LOC109989554	ENSLBEP00000006538	ENSLBEP00000016359	Ceramide kinase.	acidPPc domain-containing protein.	0.442
CERK	LOC109991296	ENSLBEP00000006538	ENSLBEP00000015121	Ceramide kinase.	Ceramide synthase 3b.	0.857
CERK	LOC109991992	ENSLBEP00000006538	ENSLBEP00000019748	Ceramide kinase.	Ceramide synthase 4b.	0.869
CERK	LOC109994192	ENSLBEP00000006538	ENSLBEP00000014275	Ceramide kinase.	Si:ch211-212g7.6.	0.536
CERK	LOC109994819	ENSLBEP00000006538	ENSLBEP00000016818	Ceramide kinase.	Zgc:158263.	0.846
CERK	LOC109995408	ENSLBEP00000006538	ENSLBEP00000016150	Ceramide kinase.	acidPPc domain-containing protein.	0.439
CERK	LOC109996162	ENSLBEP00000006538	ENSLBEP00000029339	Ceramide kinase.	Phospholipid phosphatase 2a.	0.470
CERK	LOC109996951	ENSLBEP00000006538	ENSLBEP00000012567	Ceramide kinase.	Uncharacterized protein.	0.832
CERK	LOC110002256	ENSLBEP00000006538	ENSLBEP00000001385	Ceramide kinase.	Zgc:153896.	0.847
CERK	LOC110005037	ENSLBEP00000006538	ENSLBEP00000017201	Ceramide kinase.	PAP2_C domain-containing protein.	0.882
CERK	SGPP2	ENSLBEP00000006538	ENSLBEP00000023734	Ceramide kinase.	Sphingosine-1-phosphate phosphatase 2.	0.496