(73 nodes) Mixed, incl. Phosphotyrosine residue binding, and IRS-related events triggered by IGF1R network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC110001052	Uncharacterized protein. (407 aa)
	gab2	GRB2-associated binding protein 2. (645 aa)
	ENSLBEP00000002188	Uncharacterized protein. (94 aa)
	ENSLBEP00000002343	Ras-GEF domain-containing protein. (394 aa)
	LOC109998547	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	LOC109983599	SH2 domain-containing protein. (515 aa)
	LOC109995748	GRB2 related adaptor protein a. (216 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1423 aa)
	pten	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (445 aa)
	btk	Tyrosine-protein kinase. (615 aa)
	ENSLBEP00000006037	DDE_3 domain-containing protein. (124 aa)
	LOC109988278	GRB2 related adaptor protein b. (258 aa)
	LOC109997988	GRB2 related adaptor protein 2a. (279 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (457 aa)
	ENSLBEP00000006900	Uncharacterized protein. (114 aa)
	ENSLBEP00000007186	Uncharacterized protein. (207 aa)
	insr	Tyrosine-protein kinase receptor. (1364 aa)
	LOC109984174	Receptor protein-tyrosine kinase. (742 aa)
	LOC109979027	Uncharacterized protein. (414 aa)
	ralgps2	Ral GEF with PH domain and SH3 binding motif 2. (510 aa)
	LOC110006097	Fibroblast growth factor receptor substrate 2b. (509 aa)
	LOC109979031	Uncharacterized protein. (402 aa)
	VAV1	Vav guanine nucleotide exchange factor 1. (766 aa)
	LOC109988924	Uncharacterized protein. (875 aa)
	LOC109985484	Inositol polyphosphate phosphatase-like 1b. (1216 aa)
	ENSLBEP00000013403	Uncharacterized protein. (457 aa)
	pik3cb	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1060 aa)
	igf1r	Tyrosine-protein kinase receptor. (1417 aa)
	LOC109991029	GRB2 related adaptor protein 2b. (237 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (582 aa)
	ENSLBEP00000016740	Recep_L_domain domain-containing protein. (281 aa)
	LOC109981107	Lymphocyte cytosolic protein 2b. (402 aa)
	itk	Tyrosine-protein kinase. (562 aa)
	LOC109991970	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (738 aa)
	LOC109985568	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
	LOC109996569	Insulin receptor substrate 2a. (1029 aa)
	LOC109986582	Protein tyrosine phosphatase non-receptor type 1. (462 aa)
	LOC109981016	Vav 3 guanine nucleotide exchange factor b. (783 aa)
	ENSLBEP00000020621	Rasd family member 4. (208 aa)
	LOC109989116	Uncharacterized protein. (952 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1067 aa)
	LOC109977293	PID domain-containing protein. (403 aa)
	ENSLBEP00000021967	SH2 domain-containing protein. (102 aa)
	ENSLBEP00000022348	HTH_Tnp_Tc3_2 domain-containing protein. (121 aa)
	grb2	Growth factor receptor bound protein 2. (230 aa)
	gab1	GRB2-associated binding protein 1. (707 aa)
	ENSLBEP00000023929	SH2 domain-containing protein. (80 aa)
	LOC109990780	SHC adaptor protein 3. (359 aa)
	mst1r	Macrophage stimulating 1 receptor b. (1370 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (532 aa)
	LOC110002599	PH domain-containing protein. (761 aa)
	LOC109990363	Fibroblast growth factor receptor substrate 3. (619 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (960 aa)
	LOC109992267	Receptor protein-tyrosine kinase. (1184 aa)
	LOC109980643	Macrophage stimulating 1 receptor a. (1394 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1020 aa)
	LOC109996168	Tyrosine-protein kinase receptor. (1531 aa)
	LOC109976595	Uncharacterized protein. (221 aa)
	cblb	Cbl proto-oncogene B, E3 ubiquitin protein ligase. (955 aa)
	ENSLBEP00000029977	Uncharacterized protein. (94 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (880 aa)
	LOC109986969	IGv domain-containing protein. (239 aa)
	tec	Tyrosine-protein kinase. (646 aa)
	LOC109993293	Si:ch211-284e13.4. (1158 aa)
	LOC110001378	Son of sevenless homolog 1 (Drosophila). (967 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1104 aa)
	blnk	SH2 domain-containing protein. (512 aa)
	ENSLBEP00000035319	Insulin receptor substrate 4a. (867 aa)
	LOC109990968	Uncharacterized protein. (717 aa)
	LOC110002814	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC109980706	Si:ch73-335l21.1. (1285 aa)
	LOC109987579	Tyrosine-protein kinase. (537 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000002188	ENSLBEP00000002343	ENSLBEP00000002188	ENSLBEP00000002343	Uncharacterized protein.	Ras-GEF domain-containing protein.	0.421
ENSLBEP00000002188	ENSLBEP00000006037	ENSLBEP00000002188	ENSLBEP00000006037	Uncharacterized protein.	DDE_3 domain-containing protein.	0.439
ENSLBEP00000002188	ENSLBEP00000021967	ENSLBEP00000002188	ENSLBEP00000021967	Uncharacterized protein.	SH2 domain-containing protein.	0.436
ENSLBEP00000002188	LOC109976595	ENSLBEP00000002188	ENSLBEP00000028315	Uncharacterized protein.	Uncharacterized protein.	0.732
ENSLBEP00000002188	LOC109977293	ENSLBEP00000002188	ENSLBEP00000021938	Uncharacterized protein.	PID domain-containing protein.	0.436
ENSLBEP00000002188	LOC109981016	ENSLBEP00000002188	ENSLBEP00000020361	Uncharacterized protein.	Vav 3 guanine nucleotide exchange factor b.	0.648
ENSLBEP00000002188	LOC109981107	ENSLBEP00000002188	ENSLBEP00000017426	Uncharacterized protein.	Lymphocyte cytosolic protein 2b.	0.582
ENSLBEP00000002188	LOC109983599	ENSLBEP00000002188	ENSLBEP00000002593	Uncharacterized protein.	SH2 domain-containing protein.	0.582
ENSLBEP00000002188	LOC109985568	ENSLBEP00000002188	ENSLBEP00000018851	Uncharacterized protein.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.600
ENSLBEP00000002188	LOC109988278	ENSLBEP00000002188	ENSLBEP00000006628	Uncharacterized protein.	GRB2 related adaptor protein b.	0.420
ENSLBEP00000002188	LOC109990780	ENSLBEP00000002188	ENSLBEP00000023992	Uncharacterized protein.	SHC adaptor protein 3.	0.436
ENSLBEP00000002188	LOC109991029	ENSLBEP00000002188	ENSLBEP00000015433	Uncharacterized protein.	GRB2 related adaptor protein 2b.	0.822
ENSLBEP00000002188	LOC109995748	ENSLBEP00000002188	ENSLBEP00000003377	Uncharacterized protein.	GRB2 related adaptor protein a.	0.420
ENSLBEP00000002188	LOC109997988	ENSLBEP00000002188	ENSLBEP00000006705	Uncharacterized protein.	GRB2 related adaptor protein 2a.	0.822
ENSLBEP00000002188	LOC110001378	ENSLBEP00000002188	ENSLBEP00000034168	Uncharacterized protein.	Son of sevenless homolog 1 (Drosophila).	0.421
ENSLBEP00000002188	VAV1	ENSLBEP00000002188	ENSLBEP00000010816	Uncharacterized protein.	Vav guanine nucleotide exchange factor 1.	0.648
ENSLBEP00000002188	blnk	ENSLBEP00000002188	ENSLBEP00000034910	Uncharacterized protein.	SH2 domain-containing protein.	0.582
ENSLBEP00000002188	btk	ENSLBEP00000002188	ENSLBEP00000004910	Uncharacterized protein.	Tyrosine-protein kinase.	0.639
ENSLBEP00000002188	grb2	ENSLBEP00000002188	ENSLBEP00000022583	Uncharacterized protein.	Growth factor receptor bound protein 2.	0.732
ENSLBEP00000002188	itk	ENSLBEP00000002188	ENSLBEP00000017925	Uncharacterized protein.	Tyrosine-protein kinase.	0.639