(34 nodes) Mixed, incl. PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases, and DOCK N-terminus network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109996805	Engulfment and cell motility 3. (715 aa)
	LOC109982497	Engulfment and cell motility 1. (740 aa)
	efs	Embryonal Fyn-associated substrate. (932 aa)
	ptk2b	Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (993 aa)
	LOC109983547	Ras homolog family member Gb. (191 aa)
	LOC110001552	PDZ and LIM domain 2 (mystique). (366 aa)
	LOC110005576	Tyrosine-protein kinase. (451 aa)
	git2	G protein-coupled receptor kinase interacting ArfGAP 2a. (760 aa)
	LOC109999319	Uncharacterized protein. (923 aa)
	LOC109982075	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. (571 aa)
	ENSLBEP00000012144	Uncharacterized protein. (547 aa)
	dock5	Dedicator of cytokinesis 5; Belongs to the DOCK family. (1740 aa)
	cass4	Cas scaffold protein family member 4. (795 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (318 aa)
	dock3	Dedicator of cytokinesis 3; Belongs to the DOCK family. (1919 aa)
	DOCK2	Dedicator of cytokinesis 2; Belongs to the DOCK family. (1711 aa)
	YES1	Tyrosine-protein kinase. (534 aa)
	nedd9	Neural precursor cell expressed, developmentally down-regulated 9. (826 aa)
	LOC109981137	G protein-coupled receptor kinase interacting ArfGAP 2b. (663 aa)
	LOC109994299	Leupaxin. (395 aa)
	git1	G protein-coupled receptor kinase interacting ArfGAP 1. (787 aa)
	LOC109989160	PDZ and LIM domain 5a. (577 aa)
	LOC109990303	Engulfment and cell motility 2. (733 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (475 aa)
	ENSLBEP00000030475	Focal_AT domain-containing protein. (115 aa)
	ENSLBEP00000030697	FERM_N_2 domain-containing protein. (103 aa)
	ENSLBEP00000030746	FERM domain-containing protein. (273 aa)
	crk	CRK proto-oncogene, adaptor protein. (315 aa)
	pdlim1	PDZ and LIM domain 1 (elfin). (322 aa)
	rapgef1	Rap guanine nucleotide exchange factor (GEF) 1b. (1133 aa)
	LOC109998954	Uncharacterized protein. (322 aa)
	dock1	Dedicator of cytokinesis 1; Belongs to the DOCK family. (1948 aa)
	ENSLBEP00000034706	Ras homolog gene family, member Gd. (112 aa)
	dock4	Dedicator of cytokinesis 4b; Belongs to the DOCK family. (1978 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DOCK2	ENSLBEP00000030475	ENSLBEP00000015005	ENSLBEP00000030475	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Focal_AT domain-containing protein.	0.596
DOCK2	ENSLBEP00000030697	ENSLBEP00000015005	ENSLBEP00000030697	Dedicator of cytokinesis 2; Belongs to the DOCK family.	FERM_N_2 domain-containing protein.	0.596
DOCK2	ENSLBEP00000030746	ENSLBEP00000015005	ENSLBEP00000030746	Dedicator of cytokinesis 2; Belongs to the DOCK family.	FERM domain-containing protein.	0.543
DOCK2	ENSLBEP00000034706	ENSLBEP00000015005	ENSLBEP00000034706	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Ras homolog gene family, member Gd.	0.907
DOCK2	LOC109982075	ENSLBEP00000015005	ENSLBEP00000010922	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family.	0.610
DOCK2	LOC109982497	ENSLBEP00000015005	ENSLBEP00000001655	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Engulfment and cell motility 1.	0.923
DOCK2	LOC109983547	ENSLBEP00000015005	ENSLBEP00000002186	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Ras homolog family member Gb.	0.907
DOCK2	LOC109989160	ENSLBEP00000015005	ENSLBEP00000026754	Dedicator of cytokinesis 2; Belongs to the DOCK family.	PDZ and LIM domain 5a.	0.467
DOCK2	LOC109990303	ENSLBEP00000015005	ENSLBEP00000029039	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Engulfment and cell motility 2.	0.923
DOCK2	LOC109994299	ENSLBEP00000015005	ENSLBEP00000024633	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Leupaxin.	0.610
DOCK2	LOC109996805	ENSLBEP00000015005	ENSLBEP00000000197	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Engulfment and cell motility 3.	0.923
DOCK2	LOC109998954	ENSLBEP00000015005	ENSLBEP00000032820	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Uncharacterized protein.	0.959
DOCK2	LOC109999319	ENSLBEP00000015005	ENSLBEP00000010261	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Uncharacterized protein.	0.596
DOCK2	LOC110001552	ENSLBEP00000015005	ENSLBEP00000004759	Dedicator of cytokinesis 2; Belongs to the DOCK family.	PDZ and LIM domain 2 (mystique).	0.454
DOCK2	LOC110005576	ENSLBEP00000015005	ENSLBEP00000004760	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Tyrosine-protein kinase.	0.547
DOCK2	TGFB1I1	ENSLBEP00000015005	ENSLBEP00000029438	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways.	0.610
DOCK2	YES1	ENSLBEP00000015005	ENSLBEP00000021562	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Tyrosine-protein kinase.	0.564
DOCK2	cass4	ENSLBEP00000015005	ENSLBEP00000012722	Dedicator of cytokinesis 2; Belongs to the DOCK family.	Cas scaffold protein family member 4.	0.756
DOCK2	crk	ENSLBEP00000015005	ENSLBEP00000030787	Dedicator of cytokinesis 2; Belongs to the DOCK family.	CRK proto-oncogene, adaptor protein.	0.959
DOCK2	crkl	ENSLBEP00000015005	ENSLBEP00000012981	Dedicator of cytokinesis 2; Belongs to the DOCK family.	V-crk avian sarcoma virus CT10 oncogene homolog-like.	0.959