(42 nodes) Action potential network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC110002853	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
	LOC109977366	Uncharacterized protein. (121 aa)
	LOC110000350	Potassium voltage-gated channel, subfamily H (eag-related), member 6a. (1199 aa)
	kcnmb2	Si:ch211-247n2.1. (301 aa)
	ENSLBEP00000004737	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1723 aa)
	LOC109981471	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (310 aa)
	KCNMB4	Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (124 aa)
	LOC109991070	Sodium channel, voltage-gated, type IV, beta a. (233 aa)
	LOC109991775	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1949 aa)
	scn2b	Sodium channel, voltage-gated, type II, beta. (220 aa)
	KCNH7	Potassium voltage-gated channel subfamily H member 7. (1174 aa)
	LOC109987747	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4. (369 aa)
	LOC110001033	Guanine nucleotide binding protein (G protein), alpha 14a. (354 aa)
	LOC110001032	Uncharacterized protein. (359 aa)
	LOC110004877	Guanine nucleotide-binding protein subunit alpha-14-like. (354 aa)
	ENSLBEP00000009872	Uncharacterized protein. (77 aa)
	cldn19	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
	LOC109997516	Potassium large conductance calcium-activated channel, subfamily M, beta member 2. (216 aa)
	LOC109992373	Potassium channel, voltage gated eag related subfamily H, member 7. (1228 aa)
	LOC109992374	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2023 aa)
	ENSLBEP00000014110	Uncharacterized protein. (1089 aa)
	LOC109997594	Cyclic nucleotide-binding domain-containing protein. (970 aa)
	LOC109991920	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (306 aa)
	LOC109994800	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1796 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2492 aa)
	LOC109993120	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1951 aa)
	LOC109999449	Guanine nucleotide binding protein (G protein), alpha 11a (Gq class). (402 aa)
	scn1b	Ig-like domain-containing protein. (225 aa)
	kcne4	Potassium voltage-gated channel, Isk-related family, member 4. (180 aa)
	nup155	Nucleoporin 155. (1367 aa)
	LOC109992489	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1974 aa)
	p2rx3	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (390 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (221 aa)
	ENSLBEP00000026733	Uncharacterized protein. (115 aa)
	ENSLBEP00000028785	Ion_trans domain-containing protein. (384 aa)
	GJD2	Uncharacterized protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. (303 aa)
	LOC109996180	Guanine nucleotide binding protein (G protein), alpha 11b (Gq class). (359 aa)
	LOC110005611	Uncharacterized protein; Belongs to the potassium channel family. (724 aa)
	LOC109997883	Sodium channel, voltage-gated, type I, beta a. (231 aa)
	LOC109990924	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (586 aa)
	LOC110003590	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (225 aa)
	GJD2-2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (304 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000004737	KCNMB4	ENSLBEP00000004737	ENSLBEP00000004900	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Potassium calcium-activated channel subfamily M regulatory beta subunit 4.	0.479
ENSLBEP00000004737	LOC109977366	ENSLBEP00000004737	ENSLBEP00000000716	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Uncharacterized protein.	0.479
ENSLBEP00000004737	LOC109991070	ENSLBEP00000004737	ENSLBEP00000006637	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type IV, beta a.	0.939
ENSLBEP00000004737	LOC109997883	ENSLBEP00000004737	ENSLBEP00000032098	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type I, beta a.	0.973
ENSLBEP00000004737	scn1b	ENSLBEP00000004737	ENSLBEP00000020591	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Ig-like domain-containing protein.	0.973
ENSLBEP00000004737	scn2b	ENSLBEP00000004737	ENSLBEP00000006670	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type II, beta.	0.949
ENSLBEP00000004737	scn3b	ENSLBEP00000004737	ENSLBEP00000025727	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel, voltage-gated, type III, beta.	0.805
ENSLBEP00000009872	LOC109987747	ENSLBEP00000009872	ENSLBEP00000007265	Uncharacterized protein.	Guanine nucleotide binding protein (G protein), alpha 15 (Gq class), tandem duplicate 4.	0.738
ENSLBEP00000009872	LOC110001032	ENSLBEP00000009872	ENSLBEP00000008718	Uncharacterized protein.	Uncharacterized protein.	0.825
ENSLBEP00000014110	ENSLBEP00000026733	ENSLBEP00000014110	ENSLBEP00000026733	Uncharacterized protein.	Uncharacterized protein.	0.500
ENSLBEP00000014110	kcne4	ENSLBEP00000014110	ENSLBEP00000023324	Uncharacterized protein.	Potassium voltage-gated channel, Isk-related family, member 4.	0.557
ENSLBEP00000026733	ENSLBEP00000014110	ENSLBEP00000026733	ENSLBEP00000014110	Uncharacterized protein.	Uncharacterized protein.	0.500
ENSLBEP00000026733	ENSLBEP00000028785	ENSLBEP00000026733	ENSLBEP00000028785	Uncharacterized protein.	Ion_trans domain-containing protein.	0.500
ENSLBEP00000026733	KCNH7	ENSLBEP00000026733	ENSLBEP00000006919	Uncharacterized protein.	Potassium voltage-gated channel subfamily H member 7.	0.500
ENSLBEP00000026733	LOC109990924	ENSLBEP00000026733	ENSLBEP00000034682	Uncharacterized protein.	Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family.	0.970
ENSLBEP00000026733	LOC109991070	ENSLBEP00000026733	ENSLBEP00000006637	Uncharacterized protein.	Sodium channel, voltage-gated, type IV, beta a.	0.402
ENSLBEP00000026733	LOC109992373	ENSLBEP00000026733	ENSLBEP00000011886	Uncharacterized protein.	Potassium channel, voltage gated eag related subfamily H, member 7.	0.500
ENSLBEP00000026733	LOC109997594	ENSLBEP00000026733	ENSLBEP00000014439	Uncharacterized protein.	Cyclic nucleotide-binding domain-containing protein.	0.500
ENSLBEP00000026733	LOC110000350	ENSLBEP00000026733	ENSLBEP00000000961	Uncharacterized protein.	Potassium voltage-gated channel, subfamily H (eag-related), member 6a.	0.500
ENSLBEP00000026733	LOC110005611	ENSLBEP00000026733	ENSLBEP00000029888	Uncharacterized protein.	Uncharacterized protein; Belongs to the potassium channel family.	0.970