(38 nodes) Neural tube closure network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	abl2	Tyrosine-protein kinase. (1213 aa)
	tsc2	TSC complex subunit 2. (1316 aa)
	LOC109995658	Glomulin, FKBP associated protein a. (609 aa)
	phactr4	Phosphatase and actin regulator. (890 aa)
	ccdc85b	Coiled-coil domain containing 85B. (200 aa)
	ENSLBEP00000010675	Uncharacterized protein. (243 aa)
	mks1	MKS transition zone complex subunit 1. (564 aa)
	LOC109988331	CECR2 histone acetyl-lysine reader. (1625 aa)
	dvl1	Dishevelled segment polarity protein 1a. (747 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1010 aa)
	cobl	Uncharacterized protein. (1596 aa)
	kdm6a	Lysine (K)-specific demethylase 6A. (1455 aa)
	LOC109997643	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	tmed2	Transmembrane p24 trafficking protein 2. (235 aa)
	mthfr	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (661 aa)
	dvl3	Dishevelled segment polarity protein 3a. (684 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	LOC109985118	Phosphatase and actin regulator. (468 aa)
	bbs4	Bardet-Biedl syndrome 4. (533 aa)
	LOC109983264	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (986 aa)
	abl1	Tyrosine-protein kinase. (1132 aa)
	hectd1	HECT domain containing 1. (2038 aa)
	ENSLBEP00000025925	HECT domain-containing protein. (53 aa)
	sall4	Spalt-like transcription factor 4. (1089 aa)
	LOC109985666	TSC complex subunit 1b. (1297 aa)
	LOC109989210	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (390 aa)
	setd2	SET domain containing 2, histone lysine methyltransferase. (2606 aa)
	LOC110000974	Phosphatase and actin regulator. (555 aa)
	mthfd1	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b. (934 aa)
	spint1	Serine peptidase inhibitor, Kunitz type 1 a. (496 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	ENSLBEP00000037371	FZ domain-containing protein. (284 aa)
	LOC109995113	Lysine (K)-specific demethylase 6A, like. (1234 aa)
	dvl2	Dishevelled segment polarity protein 2. (767 aa)
	ENSLBEP00000003026	Uncharacterized protein. (193 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	deaf1	DEAF1 transcription factor. (559 aa)
	ENSLBEP00000001967	Phosphatase and actin regulator. (279 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000010675	LOC109995113	ENSLBEP00000010675	ENSLBEP00000037702	Uncharacterized protein.	Lysine (K)-specific demethylase 6A, like.	0.839
ENSLBEP00000010675	PTK7	ENSLBEP00000010675	ENSLBEP00000015043	Uncharacterized protein.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.418
ENSLBEP00000010675	abl1	ENSLBEP00000010675	ENSLBEP00000025371	Uncharacterized protein.	Tyrosine-protein kinase.	0.472
ENSLBEP00000010675	abl2	ENSLBEP00000010675	ENSLBEP00000006640	Uncharacterized protein.	Tyrosine-protein kinase.	0.472
ENSLBEP00000010675	bbs4	ENSLBEP00000010675	ENSLBEP00000023312	Uncharacterized protein.	Bardet-Biedl syndrome 4.	0.483
ENSLBEP00000010675	kdm6a	ENSLBEP00000010675	ENSLBEP00000015383	Uncharacterized protein.	Lysine (K)-specific demethylase 6A.	0.839
ENSLBEP00000010675	tsc2	ENSLBEP00000010675	ENSLBEP00000008099	Uncharacterized protein.	TSC complex subunit 2.	0.993
ENSLBEP00000037371	LOC109989210	ENSLBEP00000037371	ENSLBEP00000032294	FZ domain-containing protein.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.507
ENSLBEP00000037371	LOC109997643	ENSLBEP00000037371	ENSLBEP00000016475	FZ domain-containing protein.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.507
ENSLBEP00000037371	PTK7	ENSLBEP00000037371	ENSLBEP00000015043	FZ domain-containing protein.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.524
ENSLBEP00000037371	dvl1	ENSLBEP00000037371	ENSLBEP00000014833	FZ domain-containing protein.	Dishevelled segment polarity protein 1a.	0.662
ENSLBEP00000037371	dvl2	ENSLBEP00000037371	ENSLBEP00000037824	FZ domain-containing protein.	Dishevelled segment polarity protein 2.	0.662
ENSLBEP00000037371	dvl3	ENSLBEP00000037371	ENSLBEP00000020330	FZ domain-containing protein.	Dishevelled segment polarity protein 3a.	0.662
ENSLBEP00000037371	prkacb	ENSLBEP00000037371	ENSLBEP00000035648	FZ domain-containing protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.507
LOC109983264	mthfd1	ENSLBEP00000025180	ENSLBEP00000034000	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1b.	0.842
LOC109983264	mthfr	ENSLBEP00000025180	ENSLBEP00000019373	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.937
LOC109985666	LOC109995113	ENSLBEP00000026751	ENSLBEP00000037702	TSC complex subunit 1b.	Lysine (K)-specific demethylase 6A, like.	0.839
LOC109985666	PTK7	ENSLBEP00000026751	ENSLBEP00000015043	TSC complex subunit 1b.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.418
LOC109985666	abl1	ENSLBEP00000026751	ENSLBEP00000025371	TSC complex subunit 1b.	Tyrosine-protein kinase.	0.472
LOC109985666	abl2	ENSLBEP00000026751	ENSLBEP00000006640	TSC complex subunit 1b.	Tyrosine-protein kinase.	0.472