(146 nodes) Tissue homeostasis network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	uhrf1	Ubiquitin-like with PHD and ring finger domains 1. (782 aa)
	poc1b	POC1 centriolar protein B. (525 aa)
	cluap1	Clusterin associated protein 1. (422 aa)
	cep290	Centrosomal protein 290. (2289 aa)
	LOC109989420	Whirlin b. (840 aa)
	LOC109987712	Lebercilin LCA5. (790 aa)
	ENSLBEP00000002367	Uncharacterized protein. (238 aa)
	ENSLBEP00000002295	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (137 aa)
	HOMER1	Homer scaffold protein 1. (356 aa)
	ildr2	Immunoglobulin-like domain containing receptor 2. (588 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ENSLBEP00000001919	Bardet-Biedl syndrome 12. (623 aa)
	LOC109983007	Tight junction protein 1a; Belongs to the MAGUK family. (1532 aa)
	CYTL1	Cytokine like 1. (147 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	nox4	FAD-binding FR-type domain-containing protein. (562 aa)
	LOC109977498	Proline-rich coiled-coil 1. (436 aa)
	pth	Uncharacterized protein. (99 aa)
	crb2	Crumbs cell polarity complex component 2b. (1413 aa)
	LOC109979646	Uncharacterized protein. (342 aa)
	sash3	SAM and SH3 domain containing 3. (398 aa)
	il20rb	Cytokine receptor family member B16. (296 aa)
	spata7	Spermatogenesis associated 7. (604 aa)
	ENSLBEP00000037064	Uncharacterized protein. (91 aa)
	mtf1	Metal-regulatory transcription factor 1. (810 aa)
	crb1	Crumbs cell polarity complex component 1. (1298 aa)
	nkiras1	NFKB inhibitor interacting Ras-like 1. (192 aa)
	LOC109983368	Ciliary rootlet coiled-coil, rootletin family member 2. (1738 aa)
	clrn2	Clarin 2. (233 aa)
	ccdc66	CCDC66 domain-containing protein. (825 aa)
	rb1	Retinoblastoma 1. (899 aa)
	lrrc45	Leucine rich repeat containing 45. (675 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (782 aa)
	LOC110002776	Uncharacterized protein. (415 aa)
	LOC109997304	Uncharacterized protein. (1418 aa)
	LOC109987018	Ig-like domain-containing protein. (746 aa)
	ENSLBEP00000033897	Uncharacterized protein. (99 aa)
	KLHL10	Kelch like family member 10. (577 aa)
	LOC109997912	Tight junction protein 3; Belongs to the MAGUK family. (1324 aa)
	bbs1	Bardet-Biedl syndrome 1. (584 aa)
	rp2	Protein XRP2; Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. (372 aa)
	LOC109997882	Ig-like domain-containing protein. (578 aa)
	LOC109995597	Proline-rich coiled-coil 1. (403 aa)
	strap	Serine/threonine kinase receptor associated protein. (329 aa)
	LOC110005399	BH4_2 domain-containing protein. (194 aa)
	ccn2	Cellular communication network factor 2a. (346 aa)
	tert	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1108 aa)
	LOC109996231	Tyrosine-protein kinase. (439 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	LOC110003310	BTB domain-containing protein. (585 aa)
	ENSLBEP00000030910	Uncharacterized protein. (268 aa)
	CRB2	Uncharacterized protein. (1447 aa)
	LOC109990268	Innate immunity activator b. (576 aa)
	EZH1	Enhancer of zeste 1 polycomb repressive complex 2 subunit. (803 aa)
	ENSLBEP00000028783	TGF_BETA_2 domain-containing protein. (138 aa)
	crocc	Uncharacterized protein. (1717 aa)
	LOC110005539	C-type lectin domain-containing protein. (250 aa)
	LOC110005550	C-type lectin domain-containing protein. (227 aa)
	LOC109986980	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	lrrk1	Leucine-rich repeat kinase 1. (1935 aa)
	iqcb1	Uncharacterized protein. (698 aa)
	ENSLBEP00000026210	Si:dkeyp-117h8.2. (1042 aa)
	LOC109996630	Nephronophthisis 4. (246 aa)
	trim32	Tripartite motif containing 32. (680 aa)
	whrn	Whirlin a. (984 aa)
	nxnl2	Nucleoredoxin like 2. (181 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	LOC109982254	Cathepsin H; Belongs to the peptidase C1 family. (305 aa)
	ENSLBEP00000024592	Inhibitor_I29 domain-containing protein. (125 aa)
	LOC110000139	Lysophosphatidylcholine acyltransferase 1. (500 aa)
	LOC109983926	GATA binding protein 1a. (421 aa)
	tjp2	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1290 aa)
	LOC109998277	Growth differentiation factor 5. (495 aa)
	bbs4	Bardet-Biedl syndrome 4. (533 aa)
	nrf1	Nuclear respiratory factor 1. (545 aa)
	mkks	McKusick-Kaufman syndrome. (567 aa)
	LOC109993150	Uncharacterized protein. (286 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	prlh	Prolactin releasing hormone 2. (119 aa)
	ENSLBEP00000022015	Uncharacterized protein. (435 aa)
	ENSLBEP00000021962	Uncharacterized protein. (515 aa)
	bsg	Basigin. (273 aa)
	ENSLBEP00000020795	RP1 axonemal microtubule associated. (236 aa)
	LOC109976307	PR domain containing 14. (587 aa)
	prdm14	PR domain containing 14. (598 aa)
	LOC109998752	Homer scaffold protein 1b. (363 aa)
	LOC109993135	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (675 aa)
	inava	Innate immunity activator a. (589 aa)
	clrn1	Clarin 1. (232 aa)
	LOC110002494	Tight junction protein 1b; Belongs to the MAGUK family. (1831 aa)
	ercc6	Excision repair cross-complementation group 6. (1440 aa)
	ankrd12	Ankyrin repeat domain 12. (1951 aa)
	dctn2	Dynactin 2 (p50). (404 aa)
	ENSLBEP00000017636	Uncharacterized protein. (108 aa)
	LOC109984980	Apolipoprotein D-like. (169 aa)
	LOC109985053	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (195 aa)
	LOC109984981	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (169 aa)
	LOC109978199	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
	ENSLBEP00000016937	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	ENSLBEP00000016851	Uncharacterized protein. (1537 aa)
	ENSLBEP00000016803	Uncharacterized protein. (261 aa)
	LOC109989564	Nucleoredoxin like 1. (226 aa)
	LOC109989587	Nucleoredoxin like 1. (178 aa)
	ZNF830	Zinc finger protein 830. (333 aa)
	bbs10	Uncharacterized protein; Belongs to the TCP-1 chaperonin family. (616 aa)
	srf	Serum response factor b. (526 aa)
	LOC109987139	Uncharacterized protein. (1070 aa)
	acp5	Tartrate-resistant acid phosphatase type 5. (333 aa)
	emc3	ER membrane protein complex subunit 3; Belongs to the EMC3 family. (261 aa)
	ncdn	Neurochondrin. (893 aa)
	cln8	CLN8 transmembrane ER and ERGIC protein. (288 aa)
	ENSLBEP00000013509	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (203 aa)
	SRF	Serum response factor. (278 aa)
	ENSLBEP00000012477	Uncharacterized protein. (203 aa)
	LOC109980994	Colony stimulating factor 1b (macrophage). (271 aa)
	ENSLBEP00000012199	Uncharacterized protein. (674 aa)
	LOC109975661	Intraflagellar transport 57 homolog (Chlamydomonas). (404 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (397 aa)
	PBLD	Phenazine biosynthesis like protein domain containing. (341 aa)
	ENSLBEP00000011188	Uncharacterized protein. (164 aa)
	mks1	MKS transition zone complex subunit 1. (564 aa)
	ENSLBEP00000010546	Uncharacterized protein. (190 aa)
	ENSLBEP00000010005	Uncharacterized protein. (261 aa)
	LOC110002853	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (238 aa)
	tp53inp2	Uncharacterized protein. (182 aa)
	cd34	Si:ch211-286o17.1. (354 aa)
	ENSLBEP00000008427	Uncharacterized protein. (528 aa)
	LOC109987157	BTB domain-containing protein. (595 aa)
	LOC109984383	Uncharacterized protein. (148 aa)
	mbp	Myelin basic protein b. (148 aa)
	LOC109977538	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (169 aa)
	ENSLBEP00000006251	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (183 aa)
	ENSLBEP00000006166	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	LOC109975584	Uncharacterized protein. (645 aa)
	ENSLBEP00000005998	Uncharacterized protein. (1385 aa)
	nkiras2	NFKB inhibitor interacting Ras-like 2. (192 aa)
	LOC109983874	Growth differentiation factor 6a. (440 aa)
	LOC114920595	ANK_REP_REGION domain-containing protein. (684 aa)
	ENSLBEP00000004481	Uncharacterized protein. (380 aa)
	LOC109989415	Tight junction protein 2b (zona occludens 2); Belongs to the MAGUK family. (773 aa)
	ush1c	Usher syndrome 1C. (680 aa)
	ankrd11	Ankyrin repeat domain 11. (2723 aa)
	SRC	Tyrosine-protein kinase. (549 aa)
	usp45	Ubiquitin carboxyl-terminal hydrolase. (808 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRB2	LOC109995483	ENSLBEP00000030638	ENSLBEP00000022560	Uncharacterized protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.636
CTSH	LOC110005399	ENSLBEP00000008998	ENSLBEP00000031704	Cathepsin H; Belongs to the peptidase C1 family.	BH4_2 domain-containing protein.	0.715
CTSH	bcl2	ENSLBEP00000008998	ENSLBEP00000024923	Cathepsin H; Belongs to the peptidase C1 family.	BCL2 apoptosis regulator b.	0.715
ENSLBEP00000001919	ENSLBEP00000017636	ENSLBEP00000001919	ENSLBEP00000017636	Bardet-Biedl syndrome 12.	Uncharacterized protein.	0.844
ENSLBEP00000001919	bbs1	ENSLBEP00000001919	ENSLBEP00000032407	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 1.	0.632
ENSLBEP00000001919	bbs10	ENSLBEP00000001919	ENSLBEP00000015620	Bardet-Biedl syndrome 12.	Uncharacterized protein; Belongs to the TCP-1 chaperonin family.	0.852
ENSLBEP00000001919	bbs4	ENSLBEP00000001919	ENSLBEP00000023312	Bardet-Biedl syndrome 12.	Bardet-Biedl syndrome 4.	0.627
ENSLBEP00000001919	mkks	ENSLBEP00000001919	ENSLBEP00000022702	Bardet-Biedl syndrome 12.	McKusick-Kaufman syndrome.	0.844
ENSLBEP00000002295	ENSLBEP00000004481	ENSLBEP00000002295	ENSLBEP00000004481	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.751
ENSLBEP00000002295	LOC109983007	ENSLBEP00000002295	ENSLBEP00000001698	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1a; Belongs to the MAGUK family.	0.914
ENSLBEP00000002295	LOC109989415	ENSLBEP00000002295	ENSLBEP00000004461	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 2b (zona occludens 2); Belongs to the MAGUK family.	0.818
ENSLBEP00000002295	LOC109989420	ENSLBEP00000002295	ENSLBEP00000003111	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Whirlin b.	0.455
ENSLBEP00000002295	LOC109997912	ENSLBEP00000002295	ENSLBEP00000033035	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 3; Belongs to the MAGUK family.	0.911
ENSLBEP00000002295	LOC110002494	ENSLBEP00000002295	ENSLBEP00000019196	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 1b; Belongs to the MAGUK family.	0.913
ENSLBEP00000002295	tjp2	ENSLBEP00000002295	ENSLBEP00000023419	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family.	0.818
ENSLBEP00000002295	ush1c	ENSLBEP00000002295	ENSLBEP00000004453	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Usher syndrome 1C.	0.455
ENSLBEP00000002295	whrn	ENSLBEP00000002295	ENSLBEP00000025306	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Whirlin a.	0.455
ENSLBEP00000002367	strap	ENSLBEP00000002367	ENSLBEP00000031880	Uncharacterized protein.	Serine/threonine kinase receptor associated protein.	0.600
ENSLBEP00000004481	ENSLBEP00000002295	ENSLBEP00000004481	ENSLBEP00000002295	Uncharacterized protein.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.751
ENSLBEP00000004481	ENSLBEP00000033897	ENSLBEP00000004481	ENSLBEP00000033897	Uncharacterized protein.	Uncharacterized protein.	0.751