(50 nodes) Negative regulation of cytokine-mediated signaling pathway network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	sh2b3	SH2B adaptor protein 3. (735 aa)
	LOC109983871-2	Cylindromatosis (turban tumor syndrome), b. (705 aa)
	sigirr	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain. (400 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)
	traip	TRAF-interacting protein. (449 aa)
	LOC109993147	RING-type domain-containing protein. (298 aa)
	ENSLBEP00000025063	Mitochondrial E3 ubiquitin protein ligase 1. (335 aa)
	ENSLBEP00000026155	HD domain-containing protein. (174 aa)
	ENSLBEP00000026242	HD domain-containing protein. (489 aa)
	ENSLBEP00000027339	HD domain-containing protein. (160 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (592 aa)
	ENSLBEP00000029131	RAB guanine nucleotide exchange factor (GEF) 1, like. (563 aa)
	LOC109995595	Uncharacterized protein. (994 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (956 aa)
	LOC110005387	HD domain-containing protein. (526 aa)
	ENSLBEP00000031963	HD domain-containing protein. (529 aa)
	ENSLBEP00000032001	HD_domain domain-containing protein. (195 aa)
	ENSLBEP00000032297	HD domain-containing protein. (528 aa)
	LOC109992243	Poly [ADP-ribose] polymerase. (1642 aa)
	ENSLBEP00000034439	Extracellular matrix protein 1a. (115 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1151 aa)
	OTOP1	Otopetrin 1. (596 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (486 aa)
	ENSLBEP00000038053	DC-STAMP domain containing 1. (413 aa)
	ttll12	Tubulin tyrosine ligase-like family, member 12. (637 aa)
	adar	Adenosine deaminase RNA specific. (1348 aa)
	ENSLBEP00000001463	HD_domain domain-containing protein. (190 aa)
	ENSLBEP00000001481	HD domain-containing protein. (207 aa)
	LOC109976756	HD domain-containing protein. (502 aa)
	ENSLBEP00000003307	HD domain-containing protein. (592 aa)
	LOC109990537	YTH N(6)-methyladenosine RNA binding protein 2. (646 aa)
	rnf113a	Ring finger protein 113A. (322 aa)
	LOC109980900	HD domain-containing protein. (602 aa)
	ENSLBEP00000007637	Uncharacterized protein. (450 aa)
	rabgef1	Uncharacterized protein. (499 aa)
	ENSLBEP00000011609	RING-type domain-containing protein. (316 aa)
	ENSLBEP00000014296	HD domain-containing protein. (518 aa)
	LOC109984266	Coiled-coil domain containing 3b. (277 aa)
	LOC109990113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	gas6	Growth arrest-specific 6. (627 aa)
	LOC109991911	Uncharacterized protein. (261 aa)
	il1r2	Interleukin 1 receptor type 2. (425 aa)
	LOC109977836	RAB guanine nucleotide exchange factor (GEF) 1. (513 aa)
	ENSLBEP00000017577	HD domain-containing protein. (565 aa)
	ENSLBEP00000017934	Nuclear receptor subfamily 1, group H, member 5. (478 aa)
	LOC110005080	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSLBEP00000018615	HD domain-containing protein. (495 aa)
	LOC109977202	HD domain-containing protein. (479 aa)
	ENSLBEP00000019673	HD domain-containing protein. (186 aa)
	ythdf3	YTH N(6)-methyladenosine RNA binding protein 3. (552 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000017934	pias4	ENSLBEP00000017934	ENSLBEP00000023757	Nuclear receptor subfamily 1, group H, member 5.	Protein inhibitor of activated STAT, 4a.	0.421
ENSLBEP00000029131	LOC109977836	ENSLBEP00000029131	ENSLBEP00000017477	RAB guanine nucleotide exchange factor (GEF) 1, like.	RAB guanine nucleotide exchange factor (GEF) 1.	0.689
ENSLBEP00000029131	rabgef1	ENSLBEP00000029131	ENSLBEP00000009599	RAB guanine nucleotide exchange factor (GEF) 1, like.	Uncharacterized protein.	0.688
ENSLBEP00000029131	sigirr	ENSLBEP00000029131	ENSLBEP00000023085	RAB guanine nucleotide exchange factor (GEF) 1, like.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.425
LOC109977836	ENSLBEP00000029131	ENSLBEP00000017477	ENSLBEP00000029131	RAB guanine nucleotide exchange factor (GEF) 1.	RAB guanine nucleotide exchange factor (GEF) 1, like.	0.689
LOC109977836	rabgef1	ENSLBEP00000017477	ENSLBEP00000009599	RAB guanine nucleotide exchange factor (GEF) 1.	Uncharacterized protein.	0.685
LOC109977836	sigirr	ENSLBEP00000017477	ENSLBEP00000023085	RAB guanine nucleotide exchange factor (GEF) 1.	Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain.	0.425
LOC109983871-2	LOC109995595	ENSLBEP00000023025	ENSLBEP00000029408	Cylindromatosis (turban tumor syndrome), b.	Uncharacterized protein.	0.851
LOC109983871-2	cyld	ENSLBEP00000023025	ENSLBEP00000030547	Cylindromatosis (turban tumor syndrome), b.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.848
LOC109983871-2	traip	ENSLBEP00000023025	ENSLBEP00000024391	Cylindromatosis (turban tumor syndrome), b.	TRAF-interacting protein.	0.448
LOC109990113	adar	ENSLBEP00000015571	ENSLBEP00000000479	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Adenosine deaminase RNA specific.	0.503
LOC109990537	mettl3	ENSLBEP00000005314	ENSLBEP00000027657	YTH N(6)-methyladenosine RNA binding protein 2.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.592
LOC109995595	LOC109983871-2	ENSLBEP00000029408	ENSLBEP00000023025	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), b.	0.851
LOC109995595	cyld	ENSLBEP00000029408	ENSLBEP00000030547	Uncharacterized protein.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.848
LOC109995595	traip	ENSLBEP00000029408	ENSLBEP00000024391	Uncharacterized protein.	TRAF-interacting protein.	0.418
adar	LOC109990113	ENSLBEP00000000479	ENSLBEP00000015571	Adenosine deaminase RNA specific.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.503
cyld	LOC109983871-2	ENSLBEP00000030547	ENSLBEP00000023025	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Cylindromatosis (turban tumor syndrome), b.	0.848
cyld	LOC109995595	ENSLBEP00000030547	ENSLBEP00000029408	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.848
cyld	traip	ENSLBEP00000030547	ENSLBEP00000024391	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	TRAF-interacting protein.	0.448
mettl3	LOC109990537	ENSLBEP00000027657	ENSLBEP00000005314	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.592