(64 nodes) Learning network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	cln8	CLN8 transmembrane ER and ERGIC protein. (288 aa)
	ENSLBEP00000000453	SH3 and multiple ankyrin repeat domains 3a. (1322 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	shank2	SH3 and multiple ankyrin repeat domains 2a. (1805 aa)
	LOC109977486	Voltage-dependent anion channel 1. (282 aa)
	LOC109987702	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	LOC109981886	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	LOC109989429	3-hydroxy-3-methylglutaryl coenzyme A reductase. (885 aa)
	shank1	SH3 and multiple ankyrin repeat domains 1. (840 aa)
	ENSLBEP00000006058	Uncharacterized protein. (122 aa)
	LOC109983128	Protein phosphatase 1, regulatory (inhibitor) subunit 1B. (142 aa)
	zzef1	Zinc finger, ZZ-type with EF hand domain 1. (2851 aa)
	tanc1	Uncharacterized protein. (1933 aa)
	ENSLBEP00000007961	Pentaxin. (221 aa)
	cntn2	Contactin 2. (1069 aa)
	fosl1	FOS-like antigen 1a. (344 aa)
	LOC109980925	AXH domain-containing protein. (518 aa)
	ENSLBEP00000010675	Uncharacterized protein. (243 aa)
	LOC110000507	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	SRF	Serum response factor. (278 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (170 aa)
	aaas	Achalasia, adrenocortical insufficiency, alacrimia. (519 aa)
	nptn	Neuroplastin b. (394 aa)
	ctns	Cystinosin, lysosomal cystine transporter. (381 aa)
	htt	Huntingtin. (3002 aa)
	srf	Serum response factor b. (526 aa)
	ENSLBEP00000015105	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (291 aa)
	LOC109989027	Capicua transcriptional repressor b. (2638 aa)
	slc7a11	Solute carrier family 7 member 11. (472 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (616 aa)
	mecp2	Methyl CpG binding protein 2. (1036 aa)
	RELN	Reelin. (3414 aa)
	LOC110003082	Uncharacterized protein. (380 aa)
	neto1	Neuropilin (NRP) and tolloid (TLL)-like 1, like. (531 aa)
	LOC110004274	Si:ch73-330k17.3. (221 aa)
	LOC109986061	YTH N(6)-methyladenosine RNA binding protein 1. (614 aa)
	ENSLBEP00000021437	Uncharacterized protein. (247 aa)
	ucn	Urotensin 1. (121 aa)
	ENSLBEP00000023069	Uncharacterized protein. (86 aa)
	epm2a	EPM2A glucan phosphatase, laforin. (316 aa)
	UBE3A	Ubiquitin protein ligase E3A. (789 aa)
	NRGN	Neurogranin. (65 aa)
	nf1	Neurofibromin 1b. (2672 aa)
	LOC109985666	TSC complex subunit 1b. (1297 aa)
	LOC109988210	Translational activator of mitochondrially encoded cytochrome c oxidase I. (297 aa)
	ENSLBEP00000029429	Pentraxin 4, long. (518 aa)
	LOC109985173	Homeobox protein engrailed-like. (292 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (432 aa)
	LOC109993913	Neuropilin (NRP) and tolloid (TLL)-like 1. (573 aa)
	LOC109994981	Ataxin 1b. (836 aa)
	atxn1	Ataxin 1a. (805 aa)
	LOC109988649	Uncharacterized protein. (627 aa)
	ENSLBEP00000033183	Uncharacterized protein. (230 aa)
	APP	Amyloid beta precursor protein. (646 aa)
	LOC109982581	Ubiquitin protein ligase E3A. (827 aa)
	LOC109997314	Homeobox protein engrailed-like. (285 aa)
	LOC109995666	Si:ch73-352p4.8. (554 aa)
	atxn1l	Ataxin 1-like. (847 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1655 aa)
	nptx2	Neuronal pentraxin 2a. (449 aa)
	ENSLBEP00000036342	Uncharacterized protein. (247 aa)
	vdac1	Voltage-dependent anion channel 1. (283 aa)
	ENSLBEP00000037562	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	LOC110002065	Rap guanine nucleotide exchange factor (GEF) 3. (748 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	RELN	ENSLBEP00000033207	ENSLBEP00000016792	Amyloid beta precursor protein.	Reelin.	0.623
APP	cntn2	ENSLBEP00000033207	ENSLBEP00000008051	Amyloid beta precursor protein.	Contactin 2.	0.754
APP	prkn	ENSLBEP00000033207	ENSLBEP00000029971	Amyloid beta precursor protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.433
EIF2AK4	ENSLBEP00000010675	ENSLBEP00000035352	ENSLBEP00000010675	Eukaryotic translation initiation factor 2 alpha kinase 4.	Uncharacterized protein.	0.480
EIF2AK4	LOC109985666	ENSLBEP00000035352	ENSLBEP00000026751	Eukaryotic translation initiation factor 2 alpha kinase 4.	TSC complex subunit 1b.	0.480
ENSLBEP00000000453	ENSLBEP00000023069	ENSLBEP00000000453	ENSLBEP00000023069	SH3 and multiple ankyrin repeat domains 3a.	Uncharacterized protein.	0.878
ENSLBEP00000000453	ENSLBEP00000033183	ENSLBEP00000000453	ENSLBEP00000033183	SH3 and multiple ankyrin repeat domains 3a.	Uncharacterized protein.	0.738
ENSLBEP00000000453	prkn	ENSLBEP00000000453	ENSLBEP00000029971	SH3 and multiple ankyrin repeat domains 3a.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.530
ENSLBEP00000000453	shank1	ENSLBEP00000000453	ENSLBEP00000004795	SH3 and multiple ankyrin repeat domains 3a.	SH3 and multiple ankyrin repeat domains 1.	0.720
ENSLBEP00000000453	shank2	ENSLBEP00000000453	ENSLBEP00000002047	SH3 and multiple ankyrin repeat domains 3a.	SH3 and multiple ankyrin repeat domains 2a.	0.720
ENSLBEP00000010675	EIF2AK4	ENSLBEP00000010675	ENSLBEP00000035352	Uncharacterized protein.	Eukaryotic translation initiation factor 2 alpha kinase 4.	0.480
ENSLBEP00000010675	LOC109982581	ENSLBEP00000010675	ENSLBEP00000033424	Uncharacterized protein.	Ubiquitin protein ligase E3A.	0.839
ENSLBEP00000010675	UBE3A	ENSLBEP00000010675	ENSLBEP00000025631	Uncharacterized protein.	Ubiquitin protein ligase E3A.	0.859
ENSLBEP00000010675	prkn	ENSLBEP00000010675	ENSLBEP00000029971	Uncharacterized protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.507
ENSLBEP00000015105	LOC110002065	ENSLBEP00000015105	ENSLBEP00000037573	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Rap guanine nucleotide exchange factor (GEF) 3.	0.835
ENSLBEP00000023069	ENSLBEP00000000453	ENSLBEP00000023069	ENSLBEP00000000453	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 3a.	0.878
ENSLBEP00000023069	ENSLBEP00000033183	ENSLBEP00000023069	ENSLBEP00000033183	Uncharacterized protein.	Uncharacterized protein.	0.878
ENSLBEP00000023069	shank1	ENSLBEP00000023069	ENSLBEP00000004795	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 1.	0.878
ENSLBEP00000023069	shank2	ENSLBEP00000023069	ENSLBEP00000002047	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 2a.	0.878
ENSLBEP00000033183	ENSLBEP00000000453	ENSLBEP00000033183	ENSLBEP00000000453	Uncharacterized protein.	SH3 and multiple ankyrin repeat domains 3a.	0.738