(36 nodes) Cyclic-nucleotide-mediated signaling network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109990228	Adenylyl cyclase-associated protein; Belongs to the CAP family. (353 aa)
	ENSLBEP00000002081	Adhesion G protein-coupled receptor G4b; Belongs to the G-protein coupled receptor 2 family. (453 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1455 aa)
	PDE7B	Phosphodiesterase 7B; Belongs to the cyclic nucleotide phosphodiesterase family. (360 aa)
	LOC109975484	Phosphodiesterase. (493 aa)
	ENSLBEP00000005674	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (183 aa)
	ENSLBEP00000006245	BZIP domain-containing protein. (78 aa)
	LOC109999316	Guanylate cyclase 1, soluble, beta 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (697 aa)
	ENSLBEP00000013410	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (397 aa)
	LOC110001146	Adhesion G protein-coupled receptor G2a; Belongs to the G-protein coupled receptor 2 family. (872 aa)
	ENSLBEP00000016218	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (308 aa)
	CREB1	cAMP responsive element binding protein 1. (318 aa)
	ENSLBEP00000019932	annotation not available (396 aa)
	pde7a	Phosphodiesterase. (509 aa)
	LOC109990231	Uncharacterized protein. (251 aa)
	LOC109985061	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	LOC109975219	Uncharacterized protein. (251 aa)
	DGKQ	Diacylglycerol kinase. (840 aa)
	LOC109992527	Activating transcription factor 1. (271 aa)
	GUCY1A2	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
	LOC109999709	Phosphodiesterase. (535 aa)
	creb1	Uncharacterized protein. (329 aa)
	LOC109999589	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	ENSLBEP00000026765	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (180 aa)
	LOC109999587	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
	LOC109985114	Activity-dependent neuroprotector homeobox b. (1061 aa)
	LOC109975277	Uncharacterized protein. (265 aa)
	pde9a	Phosphodiesterase. (506 aa)
	gucy1b1	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
	gucy1a1	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (678 aa)
	LOC110003306	Uncharacterized protein. (310 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	LOC110000085	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	LOC109999084	Guanylate cyclase domain-containing protein. (565 aa)
	LOC109983459	Phosphodiesterase. (532 aa)
	LOC109992627	Guanylate cyclase domain-containing protein. (541 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	LOC110003306	ENSLBEP00000018194	ENSLBEP00000030827	cAMP responsive element binding protein 1.	Uncharacterized protein.	0.843
CREB1	creb1	ENSLBEP00000018194	ENSLBEP00000026531	cAMP responsive element binding protein 1.	Uncharacterized protein.	0.834
ENSLBEP00000005674	LOC109975277	ENSLBEP00000005674	ENSLBEP00000027739	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Uncharacterized protein.	0.541
ENSLBEP00000006245	LOC110003306	ENSLBEP00000006245	ENSLBEP00000030827	BZIP domain-containing protein.	Uncharacterized protein.	0.834
ENSLBEP00000016218	GUCY1A2	ENSLBEP00000016218	ENSLBEP00000025315	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.877
ENSLBEP00000016218	LOC109985061	ENSLBEP00000016218	ENSLBEP00000022869	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.869
ENSLBEP00000016218	LOC109992627	ENSLBEP00000016218	ENSLBEP00000037219	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein.	0.781
ENSLBEP00000016218	LOC109999084	ENSLBEP00000016218	ENSLBEP00000035729	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase domain-containing protein.	0.781
ENSLBEP00000016218	LOC109999316	ENSLBEP00000016218	ENSLBEP00000011272	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase 1, soluble, beta 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.751
ENSLBEP00000016218	LOC110000085	ENSLBEP00000016218	ENSLBEP00000033969	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.869
ENSLBEP00000016218	gucy1a1	ENSLBEP00000016218	ENSLBEP00000029918	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.877
ENSLBEP00000016218	gucy1b1	ENSLBEP00000016218	ENSLBEP00000029854	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.871
GUCY1A2	ENSLBEP00000016218	ENSLBEP00000025315	ENSLBEP00000016218	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family.	0.877
GUCY1A2	LOC109975484	ENSLBEP00000025315	ENSLBEP00000004138	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.877
GUCY1A2	LOC109983459	ENSLBEP00000025315	ENSLBEP00000036273	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.877
GUCY1A2	LOC109990228	ENSLBEP00000025315	ENSLBEP00000023846	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.586
GUCY1A2	LOC109992627	ENSLBEP00000025315	ENSLBEP00000037219	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.981
GUCY1A2	LOC109999084	ENSLBEP00000025315	ENSLBEP00000035729	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.978
GUCY1A2	LOC109999316	ENSLBEP00000025315	ENSLBEP00000011272	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase 1, soluble, beta 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.984
GUCY1A2	LOC109999709	ENSLBEP00000025315	ENSLBEP00000026172	Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Phosphodiesterase.	0.894