(72 nodes) T cell differentiation network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ptprc	Protein tyrosine phosphatase receptor type C. (1151 aa)
	sash3	SAM and SH3 domain containing 3. (398 aa)
	LOC109987580	SEFIR domain-containing protein. (448 aa)
	tcf7	Transcription factor 7. (386 aa)
	themis2	Thymocyte selection associated family member 2. (593 aa)
	LOC109994563	Ig-like domain-containing protein. (214 aa)
	LOC110001353	Tyrosine-protein kinase. (582 aa)
	ENSLBEP00000035077	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	LOC109984442	Prostaglandin E receptor 4 (subtype EP4) b. (447 aa)
	syk	Non-specific protein-tyrosine kinase. (640 aa)
	nkx2-3	NK2 homeobox 3. (343 aa)
	LOC109981931	TRAF3 interacting protein 2-like. (430 aa)
	LOC109982246	Proteasome subunit beta11b. (351 aa)
	gpr18	G protein-coupled receptor 18. (412 aa)
	LOC109983967	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	LOC109983961	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	LOC109995578	Receptor-interacting serine-threonine kinase 3. (494 aa)
	ENSLBEP00000029561	Uncharacterized protein. (289 aa)
	LOC110002643	ATP/GTP binding protein-like 1. (960 aa)
	fadd	Uncharacterized protein. (192 aa)
	LOC109995561	Ring finger and CCCH-type domains 1b. (1115 aa)
	LOC109987367-2	Rab-like protein 3. (234 aa)
	LOC109985666	TSC complex subunit 1b. (1297 aa)
	LOC109983965	Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (578 aa)
	LOC109986302	Uncharacterized protein. (819 aa)
	il7r	Fibronectin type-III domain-containing protein. (421 aa)
	abl1	Tyrosine-protein kinase. (1132 aa)
	LOC109998309	Sp3b transcription factor. (641 aa)
	ENSLBEP00000024400	Uncharacterized protein. (289 aa)
	LOC109999541	Ig-like domain-containing protein. (227 aa)
	LOC109981632	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	PRR7	Proline rich 7, synaptic. (266 aa)
	zbtb1	Zinc finger and BTB domain containing 1. (651 aa)
	ENSLBEP00000022731	SEFIR domain-containing protein. (113 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	SP3	Sp3a transcription factor. (707 aa)
	IRF1	Interferon regulatory factor. (291 aa)
	ENSLBEP00000020544	Tyrosine-protein kinase. (514 aa)
	tespa1	KRAP_IP3R_bind domain-containing protein. (678 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	lig4	DNA ligase. (827 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2492 aa)
	NKX2-3	NK2 homeobox 3. (308 aa)
	cd3e	Ig_4 domain-containing protein. (175 aa)
	ENSLBEP00000016708	Uncharacterized protein. (158 aa)
	LOC109998157	Uncharacterized protein; Belongs to the protein kinase superfamily. (449 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	srf	Serum response factor b. (526 aa)
	traf3ip2	SEFIR domain-containing protein. (444 aa)
	LOC110006230	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (484 aa)
	tbx21	T-box transcription factor 21. (616 aa)
	LOC109987367	RAB, member of RAS oncogene family-like 3. (234 aa)
	card11	Caspase recruitment domain family, member 11. (1027 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (358 aa)
	SRF	Serum response factor. (278 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (569 aa)
	ENSLBEP00000010675	Uncharacterized protein. (243 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	jak1	Tyrosine-protein kinase. (1307 aa)
	lepr	Leptin receptor. (1144 aa)
	ENSLBEP00000007781	Peptidase_M14 domain-containing protein. (205 aa)
	il6r	Interleukin 6 receptor. (592 aa)
	LOC109987107	Ring finger and CCCH-type domains 2. (866 aa)
	abl2	Tyrosine-protein kinase. (1213 aa)
	LOC109981976	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (583 aa)
	armc5	Armadillo repeat containing 5. (1267 aa)
	ENSLBEP00000004509	Chemokine (C-C motif) receptor 6b. (305 aa)
	agtpbp1	ATP/GTP binding protein 1. (1088 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (114 aa)
	rag2	Recombination activating gene 2. (533 aa)
	rag1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1066 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000004509	LOC109994563	ENSLBEP00000004509	ENSLBEP00000036345	Chemokine (C-C motif) receptor 6b.	Ig-like domain-containing protein.	0.412
ENSLBEP00000004509	jak1	ENSLBEP00000004509	ENSLBEP00000008428	Chemokine (C-C motif) receptor 6b.	Tyrosine-protein kinase.	0.699
ENSLBEP00000010675	ENSLBEP00000020544	ENSLBEP00000010675	ENSLBEP00000020544	Uncharacterized protein.	Tyrosine-protein kinase.	0.567
ENSLBEP00000010675	ENSLBEP00000022731	ENSLBEP00000010675	ENSLBEP00000022731	Uncharacterized protein.	SEFIR domain-containing protein.	0.477
ENSLBEP00000010675	LOC109981931	ENSLBEP00000010675	ENSLBEP00000031528	Uncharacterized protein.	TRAF3 interacting protein 2-like.	0.477
ENSLBEP00000010675	LOC109987367	ENSLBEP00000010675	ENSLBEP00000013756	Uncharacterized protein.	RAB, member of RAS oncogene family-like 3.	0.689
ENSLBEP00000010675	LOC109987367-2	ENSLBEP00000010675	ENSLBEP00000027123	Uncharacterized protein.	Rab-like protein 3.	0.689
ENSLBEP00000010675	LOC109987580	ENSLBEP00000010675	ENSLBEP00000038379	Uncharacterized protein.	SEFIR domain-containing protein.	0.477
ENSLBEP00000010675	LOC109995578	ENSLBEP00000010675	ENSLBEP00000029624	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 3.	0.567
ENSLBEP00000010675	LOC109998157	ENSLBEP00000010675	ENSLBEP00000016647	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.567
ENSLBEP00000010675	LOC110001353	ENSLBEP00000010675	ENSLBEP00000035798	Uncharacterized protein.	Tyrosine-protein kinase.	0.567
ENSLBEP00000010675	abl1	ENSLBEP00000010675	ENSLBEP00000025371	Uncharacterized protein.	Tyrosine-protein kinase.	0.472
ENSLBEP00000010675	abl2	ENSLBEP00000010675	ENSLBEP00000006640	Uncharacterized protein.	Tyrosine-protein kinase.	0.472
ENSLBEP00000010675	fadd	ENSLBEP00000010675	ENSLBEP00000028812	Uncharacterized protein.	Uncharacterized protein.	0.535
ENSLBEP00000010675	jak1	ENSLBEP00000010675	ENSLBEP00000008428	Uncharacterized protein.	Tyrosine-protein kinase.	0.479
ENSLBEP00000010675	mtor	ENSLBEP00000010675	ENSLBEP00000018404	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.961
ENSLBEP00000010675	ripk2	ENSLBEP00000010675	ENSLBEP00000010906	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.567
ENSLBEP00000010675	stk11	ENSLBEP00000010675	ENSLBEP00000000386	Uncharacterized protein.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.684
ENSLBEP00000010675	syk	ENSLBEP00000010675	ENSLBEP00000032585	Uncharacterized protein.	Non-specific protein-tyrosine kinase.	0.567
ENSLBEP00000010675	traf3ip2	ENSLBEP00000010675	ENSLBEP00000014943	Uncharacterized protein.	SEFIR domain-containing protein.	0.477