(82 nodes) Regulation of BMP signaling pathway network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tll1	Metalloendopeptidase. (1028 aa)
	ENSLBEP00000037371	FZ domain-containing protein. (284 aa)
	numa1	Uncharacterized protein. (1912 aa)
	ENSLBEP00000037044	Noggin; Belongs to the noggin family. (217 aa)
	LOC109998484	Ring finger protein 165a. (349 aa)
	lemd3	LEM domain containing 3. (841 aa)
	sfrp1	Secreted frizzled-related protein 1a. (308 aa)
	UBE2O	Ubiquitin conjugating enzyme E2 O. (865 aa)
	GREM1	Gremlin. (182 aa)
	ENSLBEP00000035034	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (865 aa)
	bmp2	Bone morphogenetic protein 2b. (422 aa)
	LOC109985163	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (992 aa)
	LOC109998931	Mothers against decapentaplegic homolog. (563 aa)
	sfrp5	Secreted frizzled-related protein 5. (321 aa)
	LOC109980660	V-ski avian sarcoma viral oncogene homolog b. (638 aa)
	fst	Follistatin a. (348 aa)
	tnfaip6	Tumor necrosis factor, alpha-induced protein 6. (263 aa)
	LOC110001275	E3 ubiquitin-protein ligase. (786 aa)
	SFRP1	Secreted frizzled related protein 1. (191 aa)
	ENSLBEP00000028783	TGF_BETA_2 domain-containing protein. (138 aa)
	LOC110002633	Hemojuvelin BMP co-receptor. (406 aa)
	ENSLBEP00000028437	SKI family transcriptional corepressor 2. (312 aa)
	grem2	Gremlin 2, DAN family BMP antagonist a. (192 aa)
	spart	Spartin a. (532 aa)
	HTRA3	HtrA serine peptidase 3. (469 aa)
	LOC110001197	BMP binding endothelial regulator. (651 aa)
	LOC109986900	E3 ubiquitin-protein ligase. (735 aa)
	LOC109986853	SKI family transcriptional corepressor 1. (742 aa)
	LOC109996127	Uncharacterized protein. (251 aa)
	LOC109986827	Mothers against decapentaplegic homolog. (506 aa)
	fkbp8	Peptidylprolyl isomerase. (399 aa)
	LOC109981172	Mothers against decapentaplegic homolog. (503 aa)
	smad7	Mothers against decapentaplegic homolog. (376 aa)
	LOC109981596	Ring finger protein 165b. (357 aa)
	LOC109998277	Growth differentiation factor 5. (495 aa)
	chrd	Chordin. (914 aa)
	foxh1	Forkhead box H1. (515 aa)
	LOC109982725	RGM domain family, member D. (434 aa)
	ski	V-ski avian sarcoma viral oncogene homolog a. (734 aa)
	fstl3	Follistatin-like 3 (secreted glycoprotein). (250 aa)
	LOC109988455	Gremlin 1a, DAN family BMP antagonist. (196 aa)
	smad6	Mothers against decapentaplegic homolog. (491 aa)
	skor1	SKI family transcriptional corepressor 1b. (748 aa)
	LOC109979353	UBIQUITIN_CONJUGAT_2 domain-containing protein. (879 aa)
	itga3	Integrin, alpha 3b; Belongs to the integrin alpha chain family. (979 aa)
	twsg1	Twisted gastrulation BMP signaling modulator 1. (225 aa)
	LOC110003845	FCP1 homology domain-containing protein. (475 aa)
	LOC109990758	Muscle segment homeobox 3. (250 aa)
	LOC109993646	Sclerostin domain-containing protein 1-like. (207 aa)
	ccn1	Cellular communication network factor 1. (374 aa)
	LOC109986765	Noggin; Belongs to the noggin family. (211 aa)
	skil	SKI-like proto-oncogene a. (765 aa)
	LOC109988384	Uncharacterized protein. (452 aa)
	LOC109993084	Sizzled. (282 aa)
	LOC109980950	UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5. (390 aa)
	smurf1	E3 ubiquitin-protein ligase. (739 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (397 aa)
	fbxl15	F-box and leucine-rich repeat protein 15. (292 aa)
	LOC110005727	Sclerostin domain containing 1b. (207 aa)
	LOC109991202	Mothers against decapentaplegic homolog. (521 aa)
	LOC109980199	Uncharacterized protein. (1775 aa)
	ENSLBEP00000008835	FKBP prolyl isomerase 16. (312 aa)
	cdh5	Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (787 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (261 aa)
	LOC110001634	Metalloendopeptidase. (970 aa)
	LOC109983874	Growth differentiation factor 6a. (440 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC109981886	Dickkopf WNT signaling pathway inhibitor 1a. (253 aa)
	sorl1	Sortilin-related receptor, L(DLR class) A repeats containing. (1974 aa)
	chrdl2	Chordin-like 2. (444 aa)
	LOC109984777	Spartin b. (600 aa)
	vwc2l	Von Willebrand factor C domain containing 2 like. (268 aa)
	LOC109993431	DAN domain family, member 5. (256 aa)
	LOC109976742	Cadherin_C domain-containing protein; Cadherins are calcium-dependent cell adhesion proteins. (192 aa)
	LOC109987075	T-box transcription factor Ta. (421 aa)
	sostdc1	Sclerostin domain containing 1a. (219 aa)
	ctdspl2	CTD small phosphatase like 2. (473 aa)
	LOC110000963	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 3. (376 aa)
	NBL1	NBL1, DAN family BMP antagonist. (192 aa)
	msx1	Muscle segment homeobox 1a. (278 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000028783	ENSLBEP00000037044	ENSLBEP00000028783	ENSLBEP00000037044	TGF_BETA_2 domain-containing protein.	Noggin; Belongs to the noggin family.	0.909
ENSLBEP00000028783	GREM1	ENSLBEP00000028783	ENSLBEP00000035477	TGF_BETA_2 domain-containing protein.	Gremlin.	0.825
ENSLBEP00000028783	LOC109981172	ENSLBEP00000028783	ENSLBEP00000023864	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.411
ENSLBEP00000028783	LOC109982725	ENSLBEP00000028783	ENSLBEP00000021703	TGF_BETA_2 domain-containing protein.	RGM domain family, member D.	0.597
ENSLBEP00000028783	LOC109985163	ENSLBEP00000028783	ENSLBEP00000033377	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.832
ENSLBEP00000028783	LOC109986765	ENSLBEP00000028783	ENSLBEP00000017862	TGF_BETA_2 domain-containing protein.	Noggin; Belongs to the noggin family.	0.878
ENSLBEP00000028783	LOC109988455	ENSLBEP00000028783	ENSLBEP00000020345	TGF_BETA_2 domain-containing protein.	Gremlin 1a, DAN family BMP antagonist.	0.842
ENSLBEP00000028783	LOC109991202	ENSLBEP00000028783	ENSLBEP00000009797	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.411
ENSLBEP00000028783	LOC109998931	ENSLBEP00000028783	ENSLBEP00000032363	TGF_BETA_2 domain-containing protein.	Mothers against decapentaplegic homolog.	0.411
ENSLBEP00000028783	LOC110002633	ENSLBEP00000028783	ENSLBEP00000028705	TGF_BETA_2 domain-containing protein.	Hemojuvelin BMP co-receptor.	0.597
ENSLBEP00000028783	NBL1	ENSLBEP00000028783	ENSLBEP00000000798	TGF_BETA_2 domain-containing protein.	NBL1, DAN family BMP antagonist.	0.839
ENSLBEP00000028783	bmp2	ENSLBEP00000028783	ENSLBEP00000034006	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 2b.	0.691
ENSLBEP00000028783	bmpr2	ENSLBEP00000028783	ENSLBEP00000012194	TGF_BETA_2 domain-containing protein.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.832
ENSLBEP00000028783	chrd	ENSLBEP00000028783	ENSLBEP00000022503	TGF_BETA_2 domain-containing protein.	Chordin.	0.898
ENSLBEP00000028783	fst	ENSLBEP00000028783	ENSLBEP00000031074	TGF_BETA_2 domain-containing protein.	Follistatin a.	0.459
ENSLBEP00000028783	fstl3	ENSLBEP00000028783	ENSLBEP00000021197	TGF_BETA_2 domain-containing protein.	Follistatin-like 3 (secreted glycoprotein).	0.423
ENSLBEP00000028783	grem2	ENSLBEP00000028783	ENSLBEP00000027740	TGF_BETA_2 domain-containing protein.	Gremlin 2, DAN family BMP antagonist a.	0.862
ENSLBEP00000035034	ILK	ENSLBEP00000035034	ENSLBEP00000004872	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	Integrin linked kinase.	0.591
ENSLBEP00000035034	LOC109988384	ENSLBEP00000035034	ENSLBEP00000017014	Integrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family.	Uncharacterized protein.	0.591
ENSLBEP00000037044	ENSLBEP00000028783	ENSLBEP00000037044	ENSLBEP00000028783	Noggin; Belongs to the noggin family.	TGF_BETA_2 domain-containing protein.	0.909