(40 nodes) Tumor necrosis factor-mediated signaling pathway network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (762 aa)
	LOC109983659	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (308 aa)
	LOC109976821	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (412 aa)
	ENSLBEP00000005638	IKKbetaNEMObind domain-containing protein. (509 aa)
	ENSLBEP00000005600	Uncharacterized protein. (46 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC109999248	Caspase recruitment domain family, member 14. (967 aa)
	LOC109998562	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (260 aa)
	ENSLBEP00000002674	CARD domain-containing protein. (93 aa)
	st18	ST18 C2H2C-type zinc finger transcription factor. (1013 aa)
	LOC109995112	TNF receptor-associated factor. (492 aa)
	ENSLBEP00000013847	CARD domain-containing protein. (99 aa)
	LOC109987580	SEFIR domain-containing protein. (448 aa)
	ENSLBEP00000036169	Plasmalemma vesicle associated protein b. (336 aa)
	LOC109990925	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC109991608	Inhibitor of nuclear factor kappa B kinase subunit beta. (704 aa)
	cdip1	Cell death-inducing p53 target 1. (213 aa)
	snrnp25-2	LITAF domain-containing protein. (229 aa)
	LOC110002709	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (586 aa)
	LOC109981931	TRAF3 interacting protein 2-like. (430 aa)
	LOC109998929	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (598 aa)
	ENSLBEP00000029731	CARD domain-containing protein. (92 aa)
	ENSLBEP00000029631	CARD domain-containing protein. (137 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (318 aa)
	LOC109986980	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	traf3	TNF receptor-associated factor 3. (666 aa)
	LOC109975995	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (548 aa)
	LOC109996590	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (519 aa)
	ENSLBEP00000022731	SEFIR domain-containing protein. (113 aa)
	ENSLBEP00000022369	CARD domain-containing protein. (92 aa)
	LOC109992051	Tumor necrosis factor b (TNF superfamily, member 2). (253 aa)
	ENSLBEP00000021486	CARD domain-containing protein. (103 aa)
	ENSLBEP00000017712	Protein kinase domain-containing protein. (679 aa)
	LOC109988384	Uncharacterized protein. (452 aa)
	traf3ip2	SEFIR domain-containing protein. (444 aa)
	ENSLBEP00000014596	CARD domain-containing protein. (98 aa)
	LOC109984941	Zgc:174906. (225 aa)
	ENSLBEP00000011198	Pyrin domain-containing protein. (191 aa)
	ENSLBEP00000008892	Uncharacterized protein. (305 aa)
	ENSLBEP00000008609	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (402 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSLBEP00000005638	ENSLBEP00000008404	ENSLBEP00000005638	Component of inhibitor of nuclear factor kappa B kinase complex.	IKKbetaNEMObind domain-containing protein.	0.833
CHUK	ENSLBEP00000008892	ENSLBEP00000008404	ENSLBEP00000008892	Component of inhibitor of nuclear factor kappa B kinase complex.	Uncharacterized protein.	0.805
CHUK	ENSLBEP00000017712	ENSLBEP00000008404	ENSLBEP00000017712	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein.	0.834
CHUK	LOC109975995	ENSLBEP00000008404	ENSLBEP00000023249	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.924
CHUK	LOC109976821	ENSLBEP00000008404	ENSLBEP00000006838	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.834
CHUK	LOC109983659	ENSLBEP00000008404	ENSLBEP00000007019	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.914
CHUK	LOC109990925	ENSLBEP00000008404	ENSLBEP00000034805	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.924
CHUK	LOC109991608	ENSLBEP00000008404	ENSLBEP00000033093	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.859
CHUK	LOC109995112	ENSLBEP00000008404	ENSLBEP00000001259	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor.	0.681
CHUK	LOC109996590	ENSLBEP00000008404	ENSLBEP00000023058	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.681
CHUK	LOC109998929	ENSLBEP00000008404	ENSLBEP00000030749	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.681
CHUK	LOC110002709	ENSLBEP00000008404	ENSLBEP00000031541	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.784
CHUK	nfkbia	ENSLBEP00000008404	ENSLBEP00000028970	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.914
CHUK	traf3	ENSLBEP00000008404	ENSLBEP00000024692	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor 3.	0.784
ENSLBEP00000002674	LOC109984941	ENSLBEP00000002674	ENSLBEP00000012764	CARD domain-containing protein.	Zgc:174906.	0.754
ENSLBEP00000005600	ENSLBEP00000008892	ENSLBEP00000005600	ENSLBEP00000008892	Uncharacterized protein.	Uncharacterized protein.	0.784
ENSLBEP00000005600	LOC109975995	ENSLBEP00000005600	ENSLBEP00000023249	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.782
ENSLBEP00000005600	LOC109983659	ENSLBEP00000005600	ENSLBEP00000007019	Uncharacterized protein.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.498
ENSLBEP00000005600	LOC109990925	ENSLBEP00000005600	ENSLBEP00000034805	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.782
ENSLBEP00000005600	LOC109995112	ENSLBEP00000005600	ENSLBEP00000001259	Uncharacterized protein.	TNF receptor-associated factor.	0.670