(30 nodes) Membrane protein proteolysis network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	adam10	Uncharacterized protein. (709 aa)
	LOC109998592	Uncharacterized protein. (273 aa)
	NCSTN	Nicastrin. (701 aa)
	LOC109987753	Si:ch1073-396h14.1. (677 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (238 aa)
	sppl2a	PA domain-containing protein. (537 aa)
	LOC110002853	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (574 aa)
	ENSLBEP00000011770	Rhomboid domain-containing protein. (256 aa)
	rbmx	RNA binding motif protein X-linked. (382 aa)
	clpp	ATP-dependent Clp protease proteolytic subunit. (267 aa)
	rhbdd1	Rhomboid domain containing 1. (324 aa)
	LOC109980963	Peptidase S72 domain-containing protein. (910 aa)
	LOC109990670	Beta-secretase 2; Belongs to the peptidase A1 family. (387 aa)
	bace1	Beta-secretase 1; Belongs to the peptidase A1 family. (529 aa)
	ret	Ret proto-oncogene receptor tyrosine kinase. (422 aa)
	mbtps2	Membrane-bound transcription factor peptidase, site 2. (409 aa)
	LOC109989077	ADAM metallopeptidase domain 17a. (867 aa)
	sppl2b	Signal peptide peptidase-like 2. (560 aa)
	LOC109977914	Disintegrin domain-containing protein. (453 aa)
	LOC110003142	ADAM metallopeptidase domain 10b. (789 aa)
	ENSLBEP00000020769	Peptidase S72 domain-containing protein. (893 aa)
	LOC110003829	Dystroglycan 1. (890 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	ENSLBEP00000024592	Inhibitor_I29 domain-containing protein. (125 aa)
	LOC109982254	Cathepsin H; Belongs to the peptidase C1 family. (305 aa)
	ENSLBEP00000026451	Histocompatibility (minor) 13. (195 aa)
	LOC110001224	ADAM metallopeptidase domain 17b. (898 aa)
	sppl3	Signal peptide peptidase 3. (381 aa)
	LOC110000787	Presenilin 2. (340 aa)
	LOC110002100	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (359 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSH	LOC109990670	ENSLBEP00000008998	ENSLBEP00000015992	Cathepsin H; Belongs to the peptidase C1 family.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.441
CTSH	bace1	ENSLBEP00000008998	ENSLBEP00000016031	Cathepsin H; Belongs to the peptidase C1 family.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.441
ENSLBEP00000020769	LOC109980963	ENSLBEP00000020769	ENSLBEP00000014650	Peptidase S72 domain-containing protein.	Peptidase S72 domain-containing protein.	0.891
ENSLBEP00000024592	LOC109990670	ENSLBEP00000024592	ENSLBEP00000015992	Inhibitor_I29 domain-containing protein.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.441
ENSLBEP00000024592	bace1	ENSLBEP00000024592	ENSLBEP00000016031	Inhibitor_I29 domain-containing protein.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.441
ENSLBEP00000026451	NCSTN	ENSLBEP00000026451	ENSLBEP00000005751	Histocompatibility (minor) 13.	Nicastrin.	0.418
ENSLBEP00000026451	mbtps2	ENSLBEP00000026451	ENSLBEP00000016372	Histocompatibility (minor) 13.	Membrane-bound transcription factor peptidase, site 2.	0.553
LOC109977914	LOC110003142	ENSLBEP00000019707	ENSLBEP00000020174	Disintegrin domain-containing protein.	ADAM metallopeptidase domain 10b.	0.763
LOC109977914	NCSTN	ENSLBEP00000019707	ENSLBEP00000005751	Disintegrin domain-containing protein.	Nicastrin.	0.488
LOC109977914	adam10	ENSLBEP00000019707	ENSLBEP00000033741	Disintegrin domain-containing protein.	Uncharacterized protein.	0.763
LOC109980963	ENSLBEP00000020769	ENSLBEP00000014650	ENSLBEP00000020769	Peptidase S72 domain-containing protein.	Peptidase S72 domain-containing protein.	0.891
LOC109980963	LOC110003829	ENSLBEP00000014650	ENSLBEP00000022470	Peptidase S72 domain-containing protein.	Dystroglycan 1.	0.889
LOC109982254	LOC109990670	ENSLBEP00000024653	ENSLBEP00000015992	Cathepsin H; Belongs to the peptidase C1 family.	Beta-secretase 2; Belongs to the peptidase A1 family.	0.441
LOC109982254	bace1	ENSLBEP00000024653	ENSLBEP00000016031	Cathepsin H; Belongs to the peptidase C1 family.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.441
LOC109987753	LOC110003142	ENSLBEP00000007962	ENSLBEP00000020174	Si:ch1073-396h14.1.	ADAM metallopeptidase domain 10b.	0.768
LOC109987753	NCSTN	ENSLBEP00000007962	ENSLBEP00000005751	Si:ch1073-396h14.1.	Nicastrin.	0.437
LOC109987753	adam10	ENSLBEP00000007962	ENSLBEP00000033741	Si:ch1073-396h14.1.	Uncharacterized protein.	0.770
LOC109989077	LOC110003142	ENSLBEP00000017375	ENSLBEP00000020174	ADAM metallopeptidase domain 17a.	ADAM metallopeptidase domain 10b.	0.763
LOC109989077	NCSTN	ENSLBEP00000017375	ENSLBEP00000005751	ADAM metallopeptidase domain 17a.	Nicastrin.	0.488
LOC109989077	adam10	ENSLBEP00000017375	ENSLBEP00000033741	ADAM metallopeptidase domain 17a.	Uncharacterized protein.	0.763