(52 nodes) Organ growth network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	hlx	H2.0-like homeo box 1 (Drosophila). (358 aa)
	LOC109997332	Divergent protein kinase domain 2Ab. (435 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
	map2k4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	anxa6	Annexin. (656 aa)
	ENSLBEP00000038766	Transforming growth factor, beta 2. (141 aa)
	utp25	UTP25 small subunit processor component. (772 aa)
	ENSLBEP00000028418	Uncharacterized protein. (78 aa)
	ENSLBEP00000029382	DUF3496 domain-containing protein. (482 aa)
	ENSLBEP00000029399	CCDC144C domain-containing protein. (313 aa)
	ENSLBEP00000029576	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (343 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (775 aa)
	nkx2-5	NK2 homeobox 5. (315 aa)
	LOC109997239	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
	LOC109985151	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (714 aa)
	LOC110005399	BH4_2 domain-containing protein. (194 aa)
	LOC110000840	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
	arid2	AT rich interactive domain 2 (ARID, RFX-like). (1525 aa)
	tbx20	T-box transcription factor 20. (440 aa)
	LOC109982581	Ubiquitin protein ligase E3A. (827 aa)
	ENSLBEP00000001446	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (203 aa)
	evc	Uncharacterized protein. (966 aa)
	LOC110004922	Mesoderm posterior protein 1-like. (220 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	LOC110006124	Divergent protein kinase domain 2Ab. (198 aa)
	LOC110002399	Mesoderm posterior ba. (220 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (725 aa)
	LOC109985425	Transforming growth factor beta; Belongs to the TGF-beta family. (421 aa)
	lepr	Leptin receptor. (1144 aa)
	LOC109981436	Uncharacterized protein. (790 aa)
	ENSLBEP00000007637	Uncharacterized protein. (450 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	LOC110002412	Stanniocalcin 1. (277 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	ENSLBEP00000005272	Uncharacterized protein. (339 aa)
	fxn	Frataxin. (210 aa)
	ENSLBEP00000004175	Sprouty RTK signaling antagonist 2. (376 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (388 aa)
	IER3IP1	Immediate early response 3 interacting protein 1. (73 aa)
	ENSLBEP00000001462	CNX domain-containing protein. (142 aa)
	ENSLBEP00000034439	Extracellular matrix protein 1a. (115 aa)
	LOC109986206	RAP1A, member of RAS oncogene family b. (185 aa)
	adprhl1	ADP-ribosylhydrolase like 1. (355 aa)
	LOC109998146	Uncharacterized protein. (161 aa)
	LOC109981070	Uncharacterized protein. (662 aa)
	LOC109985667	Uncharacterized protein. (185 aa)
	tgfb2	Transforming growth factor, beta 2. (275 aa)
	sav1	Salvador family WW domain containing protein 1. (400 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (348 aa)
	bcl2	BCL2 apoptosis regulator b. (229 aa)
	UBE3A	Ubiquitin protein ligase E3A. (789 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000001446	ENSLBEP00000001462	ENSLBEP00000001446	ENSLBEP00000001462	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	CNX domain-containing protein.	0.559
ENSLBEP00000001446	cav1	ENSLBEP00000001446	ENSLBEP00000003908	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.563
ENSLBEP00000001462	ENSLBEP00000001446	ENSLBEP00000001462	ENSLBEP00000001446	CNX domain-containing protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.559
ENSLBEP00000001462	ENSLBEP00000029576	ENSLBEP00000001462	ENSLBEP00000029576	CNX domain-containing protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.594
ENSLBEP00000001462	cav1	ENSLBEP00000001462	ENSLBEP00000003908	CNX domain-containing protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.563
ENSLBEP00000005272	LOC109981070	ENSLBEP00000005272	ENSLBEP00000018998	Uncharacterized protein.	Uncharacterized protein.	0.852
ENSLBEP00000005272	UBE3A	ENSLBEP00000005272	ENSLBEP00000025631	Uncharacterized protein.	Ubiquitin protein ligase E3A.	0.433
ENSLBEP00000005272	cav1	ENSLBEP00000005272	ENSLBEP00000003908	Uncharacterized protein.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.468
ENSLBEP00000029382	ENSLBEP00000029399	ENSLBEP00000029382	ENSLBEP00000029399	DUF3496 domain-containing protein.	CCDC144C domain-containing protein.	0.917
ENSLBEP00000029382	arid2	ENSLBEP00000029382	ENSLBEP00000033342	DUF3496 domain-containing protein.	AT rich interactive domain 2 (ARID, RFX-like).	0.657
ENSLBEP00000029399	ENSLBEP00000029382	ENSLBEP00000029399	ENSLBEP00000029382	CCDC144C domain-containing protein.	DUF3496 domain-containing protein.	0.917
ENSLBEP00000029399	arid2	ENSLBEP00000029399	ENSLBEP00000033342	CCDC144C domain-containing protein.	AT rich interactive domain 2 (ARID, RFX-like).	0.657
ENSLBEP00000029399	evc	ENSLBEP00000029399	ENSLBEP00000000817	CCDC144C domain-containing protein.	Uncharacterized protein.	0.418
ENSLBEP00000029576	ENSLBEP00000001462	ENSLBEP00000029576	ENSLBEP00000001462	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	CNX domain-containing protein.	0.594
ENSLBEP00000029576	cav1	ENSLBEP00000029576	ENSLBEP00000003908	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.563
ENSLBEP00000038766	LOC109985151	ENSLBEP00000038766	ENSLBEP00000031679	Transforming growth factor, beta 2.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.962
ENSLBEP00000038766	LOC109985425	ENSLBEP00000038766	ENSLBEP00000008551	Transforming growth factor, beta 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.834
ENSLBEP00000038766	LOC110000840	ENSLBEP00000038766	ENSLBEP00000032116	Transforming growth factor, beta 2.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.970
ENSLBEP00000038766	TGFBR2	ENSLBEP00000038766	ENSLBEP00000036684	Transforming growth factor, beta 2.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.970
ENSLBEP00000038766	tgfb2	ENSLBEP00000038766	ENSLBEP00000022373	Transforming growth factor, beta 2.	Transforming growth factor, beta 2.	0.927