(94 nodes) Endocrine system development network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (247 aa)
	LOC109987197	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC109998758	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (374 aa)
	ENSLBEP00000019834	Hcy-binding domain-containing protein; Involved in the regulation of homocysteine metabolism. (321 aa)
	LOC110002970	Uncharacterized protein. (329 aa)
	LOC109998011	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	LOC109981109	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (109 aa)
	LOC109997775	Uncharacterized protein. (411 aa)
	LOC109994230	Hcy-binding domain-containing protein. (455 aa)
	LOC109992429	Insulinoma-associated 1b. (384 aa)
	nkx2-2	NK2 homeobox 2a. (254 aa)
	LOC109991911	Uncharacterized protein. (261 aa)
	LOC109991924	Uncharacterized protein. (325 aa)
	srf	Serum response factor b. (526 aa)
	tbx1	T-box transcription factor 1. (519 aa)
	SRF	Serum response factor. (278 aa)
	PROP1	PROP paired-like homeobox 1. (225 aa)
	LOC109978094	GCM domain-containing protein. (329 aa)
	mnx1	Motor neuron and pancreas homeobox 1. (313 aa)
	nkx6-2	NK6 homeobox 2. (303 aa)
	ENSLBEP00000011847	Achaete-scute family bHLH transcription factor 1a. (210 aa)
	ENSLBEP00000011805	Paired domain-containing protein. (246 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (397 aa)
	LOC109996929	Uncharacterized protein. (442 aa)
	LOC109992992	Paired box 2b. (391 aa)
	LOC110006110	Insulin-like. (121 aa)
	dlx3	Distal-less homeobox 3b. (280 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (293 aa)
	LOC109981424	T-box transcription factor 2a. (621 aa)
	TBX2	T-box transcription factor 2. (686 aa)
	LOC110006056	Insulinoma-associated 1a. (440 aa)
	LOC109997493	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (524 aa)
	il6r	Interleukin 6 receptor. (592 aa)
	LOC109995271	Preproinsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (121 aa)
	LOC109975600	Homeobox domain-containing protein. (232 aa)
	eif2ak3	Eukaryotic translation initiation factor 2-alpha kinase 3. (1036 aa)
	armc5	Armadillo repeat containing 5. (1267 aa)
	LOC110000962	WT1 transcription factor a. (224 aa)
	gsx1	GS homeobox 1. (242 aa)
	ENSLBEP00000025001	Calponin-homology (CH) domain-containing protein. (272 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	LOC109981171	Regulatory factor X, 3 (influences HLA class II expression). (670 aa)
	GATA2	GATA binding protein 2. (451 aa)
	LOC109990805	Retinal homeobox gene 3. (300 aa)
	LOC109990259	Endothelin 1. (196 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (257 aa)
	LOC109996609	Paired box 8. (475 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	ENSLBEP00000022374	Uncharacterized protein. (194 aa)
	arx	Aristaless related homeobox a. (462 aa)
	LOC109988436	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	nf1	Neurofibromin 1b. (2672 aa)
	neurod1	Neurogenic differentiation factor. (347 aa)
	hand2	Heart and neural crest derivatives expressed 2. (250 aa)
	bsx	Brain-specific homeobox. (229 aa)
	hnf1b	HNF1 homeobox Ba. (576 aa)
	LOC110002626	ATP-binding cassette, sub-family D (ALD), member 1. (762 aa)
	LOC109995565	T-cell acute lymphocytic leukemia 1. (356 aa)
	disp1	Dispatched homolog 1 (Drosophila). (1610 aa)
	LOC109998905	Uncharacterized protein. (204 aa)
	LOC109998896	Zgc:153993. (205 aa)
	cdkal1	CDK5 regulatory subunit associated protein 1-like 1. (522 aa)
	ENSLBEP00000029843	Homeobox domain-containing protein. (194 aa)
	nkx2-5	NK2 homeobox 5. (315 aa)
	six6	SIX homeobox 6a. (245 aa)
	LOC109975600-2	NK2 homeobox 2b. (258 aa)
	LOC110000815	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (188 aa)
	LOC109986393	Regulatory factor X, 6. (990 aa)
	LOC109988649	Uncharacterized protein. (627 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1060 aa)
	fitm2	Fat storage inducing transmembrane protein 2. (260 aa)
	LOC110001952	GCM domain-containing protein. (449 aa)
	LOC110001377	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	LOC110001396	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (464 aa)
	ENSLBEP00000035060	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (522 aa)
	LOC109983387	GATA binding protein 2a. (457 aa)
	LOC109988666	Homeobox domain-containing protein. (279 aa)
	dkk3	Dickkopf WNT signaling pathway inhibitor 3a. (290 aa)
	LOC109993326	SIX homeobox 3b. (271 aa)
	six3	SIX homeobox 3a. (294 aa)
	ENSLBEP00000037495	SIX homeobox 7. (308 aa)
	LOC109976748	Homeobox protein. (294 aa)
	ENSLBEP00000038588	Dickkopf WNT signaling pathway inhibitor 3b. (271 aa)
	nkx6-1	NK6 homeobox 1. (335 aa)
	LOC109988849	Mediator complex subunit 12. (2054 aa)
	pax5	Paired box 5. (396 aa)
	LOC109977896	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1236 aa)
	LOC109983905	P/Homo B domain-containing protein. (539 aa)
	wt1	WT1 transcription factor b. (427 aa)
	pax6	Paired box 6b. (457 aa)
	LOC109990602	Achaete-scute family bHLH transcription factor 1b. (204 aa)
	LOC110000915	Betaine-homocysteine methyltransferase. (435 aa)
	LOC109981909	Paired box 2a. (417 aa)
	pcsk1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (781 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000011847	GATA2	ENSLBEP00000011847	ENSLBEP00000023306	Achaete-scute family bHLH transcription factor 1a.	GATA binding protein 2.	0.456
ENSLBEP00000011847	LOC109983387	ENSLBEP00000011847	ENSLBEP00000035267	Achaete-scute family bHLH transcription factor 1a.	GATA binding protein 2a.	0.456
ENSLBEP00000011847	arx	ENSLBEP00000011847	ENSLBEP00000022233	Achaete-scute family bHLH transcription factor 1a.	Aristaless related homeobox a.	0.408
ENSLBEP00000011847	gsx1	ENSLBEP00000011847	ENSLBEP00000004705	Achaete-scute family bHLH transcription factor 1a.	GS homeobox 1.	0.442
ENSLBEP00000011847	neurod1	ENSLBEP00000011847	ENSLBEP00000027225	Achaete-scute family bHLH transcription factor 1a.	Neurogenic differentiation factor.	0.467
ENSLBEP00000029843	GATA2	ENSLBEP00000029843	ENSLBEP00000023306	Homeobox domain-containing protein.	GATA binding protein 2.	0.410
ENSLBEP00000029843	LOC109983387	ENSLBEP00000029843	ENSLBEP00000035267	Homeobox domain-containing protein.	GATA binding protein 2a.	0.410
ENSLBEP00000029843	SRF	ENSLBEP00000029843	ENSLBEP00000012673	Homeobox domain-containing protein.	Serum response factor.	0.575
ENSLBEP00000029843	srf	ENSLBEP00000029843	ENSLBEP00000015093	Homeobox domain-containing protein.	Serum response factor b.	0.575
ENSLBEP00000035060	LOC109988849	ENSLBEP00000035060	ENSLBEP00000004642	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family.	Mediator complex subunit 12.	0.536
ENSLBEP00000035060	il6r	ENSLBEP00000035060	ENSLBEP00000007297	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family.	Interleukin 6 receptor.	0.450
GATA2	ENSLBEP00000011847	ENSLBEP00000023306	ENSLBEP00000011847	GATA binding protein 2.	Achaete-scute family bHLH transcription factor 1a.	0.456
GATA2	ENSLBEP00000029843	ENSLBEP00000023306	ENSLBEP00000029843	GATA binding protein 2.	Homeobox domain-containing protein.	0.410
GATA2	LOC109981424	ENSLBEP00000023306	ENSLBEP00000010243	GATA binding protein 2.	T-box transcription factor 2a.	0.459
GATA2	LOC109990602	ENSLBEP00000023306	ENSLBEP00000002191	GATA binding protein 2.	Achaete-scute family bHLH transcription factor 1b.	0.456
GATA2	LOC109990805	ENSLBEP00000023306	ENSLBEP00000022827	GATA binding protein 2.	Retinal homeobox gene 3.	0.410
GATA2	LOC109995565	ENSLBEP00000023306	ENSLBEP00000027978	GATA binding protein 2.	T-cell acute lymphocytic leukemia 1.	0.840
GATA2	PROP1	ENSLBEP00000023306	ENSLBEP00000012555	GATA binding protein 2.	PROP paired-like homeobox 1.	0.424
GATA2	SRF	ENSLBEP00000023306	ENSLBEP00000012673	GATA binding protein 2.	Serum response factor.	0.717
GATA2	TBX2	ENSLBEP00000023306	ENSLBEP00000010068	GATA binding protein 2.	T-box transcription factor 2.	0.459