(25 nodes) CD4-positive, alpha-beta T cell activation network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NKX2-3	NK2 homeobox 3. (308 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2492 aa)
	lef1	Lymphoid enhancer-binding factor 1. (379 aa)
	ENSLBEP00000021346	Uncharacterized protein. (535 aa)
	LOC109985574	E3 ubiquitin-protein ligase. (880 aa)
	LOC109981632	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	LOC109999541	Ig-like domain-containing protein. (227 aa)
	LOC109995561	Ring finger and CCCH-type domains 1b. (1115 aa)
	LOC109983961	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	LOC109983967	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	nkx2-3	NK2 homeobox 3. (343 aa)
	LOC109984442	Prostaglandin E receptor 4 (subtype EP4) b. (447 aa)
	sash3	SAM and SH3 domain containing 3. (398 aa)
	batf	Basic leucine zipper transcription factor, ATF-like. (114 aa)
	armc5	Armadillo repeat containing 5. (1267 aa)
	LOC109980837	E3 ubiquitin-protein ligase. (867 aa)
	LOC109987107	Ring finger and CCCH-type domains 2. (866 aa)
	il6r	Interleukin 6 receptor. (592 aa)
	tmem98	Transmembrane protein 98. (224 aa)
	cdh26	Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (829 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (569 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (358 aa)
	card11	Caspase recruitment domain family, member 11. (1027 aa)
	tbx21	T-box transcription factor 21. (616 aa)
	LOC110006230	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (484 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC109980837	lef1	ENSLBEP00000005882	ENSLBEP00000019554	E3 ubiquitin-protein ligase.	Lymphoid enhancer-binding factor 1.	0.409
LOC109980837	ripk2	ENSLBEP00000005882	ENSLBEP00000010906	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.705
LOC109985574	lef1	ENSLBEP00000021857	ENSLBEP00000019554	E3 ubiquitin-protein ligase.	Lymphoid enhancer-binding factor 1.	0.409
LOC109985574	ripk2	ENSLBEP00000021857	ENSLBEP00000010906	E3 ubiquitin-protein ligase.	Receptor-interacting serine-threonine kinase 2.	0.705
LOC109987107	LOC109995561	ENSLBEP00000006700	ENSLBEP00000028578	Ring finger and CCCH-type domains 2.	Ring finger and CCCH-type domains 1b.	0.860
LOC109995561	LOC109987107	ENSLBEP00000028578	ENSLBEP00000006700	Ring finger and CCCH-type domains 1b.	Ring finger and CCCH-type domains 2.	0.860
batf	tbx21	ENSLBEP00000001904	ENSLBEP00000013757	Basic leucine zipper transcription factor, ATF-like.	T-box transcription factor 21.	0.444
card11	ripk2	ENSLBEP00000013436	ENSLBEP00000010906	Caspase recruitment domain family, member 11.	Receptor-interacting serine-threonine kinase 2.	0.744
hlx	tbx21	ENSLBEP00000013002	ENSLBEP00000013757	H2.0-like homeo box 1 (Drosophila).	T-box transcription factor 21.	0.590
lef1	LOC109980837	ENSLBEP00000019554	ENSLBEP00000005882	Lymphoid enhancer-binding factor 1.	E3 ubiquitin-protein ligase.	0.409
lef1	LOC109985574	ENSLBEP00000019554	ENSLBEP00000021857	Lymphoid enhancer-binding factor 1.	E3 ubiquitin-protein ligase.	0.409
lef1	tbx21	ENSLBEP00000019554	ENSLBEP00000013757	Lymphoid enhancer-binding factor 1.	T-box transcription factor 21.	0.444
ripk2	LOC109980837	ENSLBEP00000010906	ENSLBEP00000005882	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.705
ripk2	LOC109985574	ENSLBEP00000010906	ENSLBEP00000021857	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase.	0.705
ripk2	card11	ENSLBEP00000010906	ENSLBEP00000013436	Receptor-interacting serine-threonine kinase 2.	Caspase recruitment domain family, member 11.	0.744
tbx21	batf	ENSLBEP00000013757	ENSLBEP00000001904	T-box transcription factor 21.	Basic leucine zipper transcription factor, ATF-like.	0.444
tbx21	hlx	ENSLBEP00000013757	ENSLBEP00000013002	T-box transcription factor 21.	H2.0-like homeo box 1 (Drosophila).	0.590
tbx21	lef1	ENSLBEP00000013757	ENSLBEP00000019554	T-box transcription factor 21.	Lymphoid enhancer-binding factor 1.	0.444