(21 nodes) Regulation of isotype switching network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rif1	Replication timing regulatory factor 1. (2650 aa)
	ENSLBEP00000000333	Uncharacterized protein. (270 aa)
	hmces	Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (354 aa)
	LOC109993446	AAA domain-containing protein. (835 aa)
	LOC109992925	Lysine methyltransferase 5C. (480 aa)
	kmt5b	Lysine methyltransferase 5B. (860 aa)
	LOC109995824	Uncharacterized protein. (1402 aa)
	LOC109977677	Uncharacterized protein. (277 aa)
	ENSLBEP00000011876	Uncharacterized protein. (726 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1151 aa)
	MSH2	MutS homolog 2. (600 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (935 aa)
	LOC109990953	Uncharacterized protein. (277 aa)
	tbx21	T-box transcription factor 21. (616 aa)
	parp3	Poly [ADP-ribose] polymerase. (527 aa)
	LOC109996990	CD40 molecule, TNF receptor superfamily member 5. (308 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (648 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1256 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	exosc3	Exosome component 3. (245 aa)
	thoc1	THO complex 1. (667 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000000333	MSH2	ENSLBEP00000000333	ENSLBEP00000000272	Uncharacterized protein.	MutS homolog 2.	0.944
ENSLBEP00000000333	mlh1	ENSLBEP00000000333	ENSLBEP00000017339	Uncharacterized protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.992
ENSLBEP00000011876	mlh1	ENSLBEP00000011876	ENSLBEP00000017339	Uncharacterized protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.412
LOC109977677	tp53bp1	ENSLBEP00000011665	ENSLBEP00000021742	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.419
LOC109990953	tp53bp1	ENSLBEP00000035546	ENSLBEP00000021742	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.419
LOC109992925	LOC109995824	ENSLBEP00000004862	ENSLBEP00000007510	Lysine methyltransferase 5C.	Uncharacterized protein.	0.723
LOC109992925	tp53bp1	ENSLBEP00000004862	ENSLBEP00000021742	Lysine methyltransferase 5C.	Tumor protein p53 binding protein, 1.	0.532
LOC109993446	mlh1	ENSLBEP00000002521	ENSLBEP00000017339	AAA domain-containing protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.412
LOC109995483	tbx21	ENSLBEP00000022560	ENSLBEP00000013757	Transforming growth factor beta; Belongs to the TGF-beta family.	T-box transcription factor 21.	0.404
LOC109995824	LOC109992925	ENSLBEP00000007510	ENSLBEP00000004862	Uncharacterized protein.	Lysine methyltransferase 5C.	0.723
LOC109995824	kmt5b	ENSLBEP00000007510	ENSLBEP00000007143	Uncharacterized protein.	Lysine methyltransferase 5B.	0.749
LOC109995824	rif1	ENSLBEP00000007510	ENSLBEP00000030714	Uncharacterized protein.	Replication timing regulatory factor 1.	0.704
LOC109995824	tp53bp1	ENSLBEP00000007510	ENSLBEP00000021742	Uncharacterized protein.	Tumor protein p53 binding protein, 1.	0.800
LOC109996990	ptprc	ENSLBEP00000016101	ENSLBEP00000036424	CD40 molecule, TNF receptor superfamily member 5.	Protein tyrosine phosphatase receptor type C.	0.523
MSH2	ENSLBEP00000000333	ENSLBEP00000000272	ENSLBEP00000000333	MutS homolog 2.	Uncharacterized protein.	0.944
MSH2	mlh1	ENSLBEP00000000272	ENSLBEP00000017339	MutS homolog 2.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.994
kmt5b	LOC109995824	ENSLBEP00000007143	ENSLBEP00000007510	Lysine methyltransferase 5B.	Uncharacterized protein.	0.749
kmt5b	tp53bp1	ENSLBEP00000007143	ENSLBEP00000021742	Lysine methyltransferase 5B.	Tumor protein p53 binding protein, 1.	0.532
mlh1	ENSLBEP00000000333	ENSLBEP00000017339	ENSLBEP00000000333	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Uncharacterized protein.	0.992
mlh1	ENSLBEP00000011876	ENSLBEP00000017339	ENSLBEP00000011876	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	Uncharacterized protein.	0.412