(47 nodes) Positive regulation of endocytosis network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC110002615	Uncharacterized protein. (1201 aa)
	LOC109985336	Vitronectin b. (445 aa)
	LOC109990192	Zgc:123278. (191 aa)
	LOC109990188	Tumor susceptibility 101a. (422 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2422 aa)
	ptpn5	Protein tyrosine phosphatase non-receptor type 5. (573 aa)
	vps28	Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. (223 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC110005588	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (163 aa)
	ankfy1	Ankyrin repeat and FYVE domain containing 1. (957 aa)
	ENSLBEP00000007328	TBC1 domain family, member 5. (764 aa)
	ENSLBEP00000008003	Abelson helper integration site 1. (858 aa)
	serpine1	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (391 aa)
	pcsk9	Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (662 aa)
	LOC109994148	Cell division cycle 42. (191 aa)
	CDC42	Cell division cycle 42. (203 aa)
	ENSLBEP00000014280	Uncharacterized protein. (87 aa)
	LOC109995395	Uncharacterized protein. (191 aa)
	appl2	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2. (665 aa)
	smpd1	Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
	fmr1	Fragile X mental retardation 1. (583 aa)
	ldlrap1	Low density lipoprotein receptor adaptor protein 1b. (313 aa)
	LOC109985036	Clusterin; Belongs to the clusterin family. (464 aa)
	LOC109988455	Gremlin 1a, DAN family BMP antagonist. (196 aa)
	cd63	Tetraspanin. (239 aa)
	clu	Clusterin; Belongs to the clusterin family. (505 aa)
	LOC109994268	Clusterin; Belongs to the clusterin family. (463 aa)
	dab2	DAB adaptor protein 2. (764 aa)
	scyl2	SCY1 like pseudokinase 2. (922 aa)
	LOC109989114	SCY domain-containing protein. (112 aa)
	LOC109981028	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (584 aa)
	LOC109990231	Uncharacterized protein. (251 aa)
	LOC109975219	Uncharacterized protein. (251 aa)
	ppt1	Palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile). (303 aa)
	LOC109978574	Rab-GAP TBC domain-containing protein. (321 aa)
	LOC109998849	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1316 aa)
	ENSLBEP00000027466	PDZ domain-containing protein. (150 aa)
	LOC110003296	Uncharacterized protein. (138 aa)
	LOC109982914	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (232 aa)
	LOC109993319	Eukaryotic elongation factor 2 kinase. (709 aa)
	LOC109993962	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase. (462 aa)
	GREM1	Gremlin. (182 aa)
	LOC109987997	Vitronectin a. (560 aa)
	appl1	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1. (705 aa)
	LOC110002047	PDZ domain-containing protein. (164 aa)
	cln3	Battenin. (436 aa)
	ano6	Anoctamin. (920 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	ENSLBEP00000027466	ENSLBEP00000014221	ENSLBEP00000027466	Cell division cycle 42.	PDZ domain-containing protein.	0.599
CDC42	LOC109995395	ENSLBEP00000014221	ENSLBEP00000015957	Cell division cycle 42.	Uncharacterized protein.	0.815
CDC42	LOC109998849	ENSLBEP00000014221	ENSLBEP00000025285	Cell division cycle 42.	Membrane associated guanylate kinase, WW and PDZ domain containing 2a.	0.599
CDC42	LOC110002047	ENSLBEP00000014221	ENSLBEP00000037198	Cell division cycle 42.	PDZ domain-containing protein.	0.599
CDC42	LOC110002615	ENSLBEP00000014221	ENSLBEP00000027222	Cell division cycle 42.	Uncharacterized protein.	0.599
CDC42	LOC110003296	ENSLBEP00000014221	ENSLBEP00000030398	Cell division cycle 42.	Uncharacterized protein.	0.816
CDC42	ankfy1	ENSLBEP00000014221	ENSLBEP00000006704	Cell division cycle 42.	Ankyrin repeat and FYVE domain containing 1.	0.640
CDC42	appl1	ENSLBEP00000014221	ENSLBEP00000036322	Cell division cycle 42.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.400
CDC42	appl2	ENSLBEP00000014221	ENSLBEP00000016480	Cell division cycle 42.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.	0.400
ENSLBEP00000014280	cln3	ENSLBEP00000014280	ENSLBEP00000038307	Uncharacterized protein.	Battenin.	0.585
ENSLBEP00000027466	CDC42	ENSLBEP00000027466	ENSLBEP00000014221	PDZ domain-containing protein.	Cell division cycle 42.	0.599
ENSLBEP00000027466	LOC109994148	ENSLBEP00000027466	ENSLBEP00000013739	PDZ domain-containing protein.	Cell division cycle 42.	0.599
ENSLBEP00000027466	LOC109995395	ENSLBEP00000027466	ENSLBEP00000015957	PDZ domain-containing protein.	Uncharacterized protein.	0.599
ENSLBEP00000027466	LOC110002615	ENSLBEP00000027466	ENSLBEP00000027222	PDZ domain-containing protein.	Uncharacterized protein.	0.579
ENSLBEP00000027466	LOC110003296	ENSLBEP00000027466	ENSLBEP00000030398	PDZ domain-containing protein.	Uncharacterized protein.	0.599
GREM1	LOC109988455	ENSLBEP00000035477	ENSLBEP00000020345	Gremlin.	Gremlin 1a, DAN family BMP antagonist.	0.842
LOC109975219	LOC109981028	ENSLBEP00000023316	ENSLBEP00000022031	Uncharacterized protein.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.406
LOC109975219	LOC109985336	ENSLBEP00000023316	ENSLBEP00000000708	Uncharacterized protein.	Vitronectin b.	0.536
LOC109975219	LOC109987997	ENSLBEP00000023316	ENSLBEP00000036040	Uncharacterized protein.	Vitronectin a.	0.536
LOC109975219	appl1	ENSLBEP00000023316	ENSLBEP00000036322	Uncharacterized protein.	Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1.	0.411