(21 nodes) Negative regulation of smoothened signaling pathway network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpr161	G protein-coupled receptor 161. (536 aa)
	IFT122	Intraflagellar transport 122. (1184 aa)
	LOC109991929	GLIS family zinc finger 2a. (484 aa)
	RFX4	Regulatory factor X4. (302 aa)
	LOC109997643	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	mgrn1	Mahogunin, ring finger 1b. (511 aa)
	LOC109981028	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (584 aa)
	ptch2	Patched 2. (1491 aa)
	serpine2	Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2; Belongs to the serpin family. (397 aa)
	ENSLBEP00000023548	Uncharacterized protein. (250 aa)
	ulk3	Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (491 aa)
	hhip	Hedgehog interacting protein. (697 aa)
	rest	RE1-silencing transcription factor. (1018 aa)
	LOC109976615	Uncharacterized protein. (281 aa)
	kif7	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1399 aa)
	LOC109989210	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (390 aa)
	LOC109985874	Uncharacterized protein. (167 aa)
	rfx4	Regulatory factor X, 4. (737 aa)
	glis2	GLIS family zinc finger 2b. (484 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	rb1	Retinoblastoma 1. (899 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000023548	hhip	ENSLBEP00000023548	ENSLBEP00000023832	Uncharacterized protein.	Hedgehog interacting protein.	0.472
ENSLBEP00000023548	ptch2	ENSLBEP00000023548	ENSLBEP00000022822	Uncharacterized protein.	Patched 2.	0.912
IFT122	LOC109989210	ENSLBEP00000007257	ENSLBEP00000032294	Intraflagellar transport 122.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.521
IFT122	LOC109991929	ENSLBEP00000007257	ENSLBEP00000013984	Intraflagellar transport 122.	GLIS family zinc finger 2a.	0.404
IFT122	LOC109997643	ENSLBEP00000007257	ENSLBEP00000016475	Intraflagellar transport 122.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.521
IFT122	glis2	ENSLBEP00000007257	ENSLBEP00000035418	Intraflagellar transport 122.	GLIS family zinc finger 2b.	0.404
IFT122	gpr161	ENSLBEP00000007257	ENSLBEP00000001780	Intraflagellar transport 122.	G protein-coupled receptor 161.	0.767
IFT122	kif7	ENSLBEP00000007257	ENSLBEP00000031167	Intraflagellar transport 122.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.476
IFT122	prkacb	ENSLBEP00000007257	ENSLBEP00000035648	Intraflagellar transport 122.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.521
IFT122	rb1	ENSLBEP00000007257	ENSLBEP00000035832	Intraflagellar transport 122.	Retinoblastoma 1.	0.474
LOC109981028	ptch2	ENSLBEP00000022031	ENSLBEP00000022822	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Patched 2.	0.455
LOC109989210	IFT122	ENSLBEP00000032294	ENSLBEP00000007257	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Intraflagellar transport 122.	0.521
LOC109989210	LOC109997643	ENSLBEP00000032294	ENSLBEP00000016475	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.832
LOC109989210	gpr161	ENSLBEP00000032294	ENSLBEP00000001780	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	G protein-coupled receptor 161.	0.847
LOC109989210	kif7	ENSLBEP00000032294	ENSLBEP00000031167	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.761
LOC109989210	ulk3	ENSLBEP00000032294	ENSLBEP00000023656	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Unc-51 like kinase 3; Belongs to the protein kinase superfamily.	0.520
LOC109991929	IFT122	ENSLBEP00000013984	ENSLBEP00000007257	GLIS family zinc finger 2a.	Intraflagellar transport 122.	0.404
LOC109997643	IFT122	ENSLBEP00000016475	ENSLBEP00000007257	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Intraflagellar transport 122.	0.521
LOC109997643	LOC109989210	ENSLBEP00000016475	ENSLBEP00000032294	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.832
LOC109997643	gpr161	ENSLBEP00000016475	ENSLBEP00000001780	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	G protein-coupled receptor 161.	0.847