(82 nodes) Developmental cell growth network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109996037	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (566 aa)
	LOC110003002	Uncharacterized protein; Belongs to the semaphorin family. (592 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (606 aa)
	LOC109990259	Endothelin 1. (196 aa)
	SPAST	Spastin; Belongs to the AAA ATPase family. (462 aa)
	LOC110002537	Vinculin a. (596 aa)
	tnn	Tenascin N. (1119 aa)
	mycbp2	MYC binding protein 2. (4537 aa)
	EIF2AK4	Eukaryotic translation initiation factor 2 alpha kinase 4. (1655 aa)
	LOC110001396	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (464 aa)
	fam53b	Family with sequence similarity 53 member B. (413 aa)
	raph1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b. (570 aa)
	APP	Amyloid beta precursor protein. (646 aa)
	LOC109983354	Unc-51 like autophagy activating kinase 1a. (917 aa)
	LOC109996721	Slit homolog 1a (Drosophila). (1384 aa)
	cyfip1	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
	LOC110000840	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
	LOC110005739	Neuritin 1-like b. (162 aa)
	ENSLBEP00000004382	LRRNT domain-containing protein. (166 aa)
	LOC109991013	Fibronectin type-III domain-containing protein. (685 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	ubap1	Ubiquitin associated protein 1. (465 aa)
	LOC109987072	Endothelin 2. (219 aa)
	ENSLBEP00000002337	Uncharacterized protein. (423 aa)
	LOC109984747	Doublecortin-like kinase 1b. (752 aa)
	dcx	Uncharacterized protein. (346 aa)
	ist1	IST1 factor associated with ESCRT-III. (359 aa)
	ENSLBEP00000003753	Uncharacterized protein. (481 aa)
	LOC109984777	Spartin b. (600 aa)
	LOC109985151	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (714 aa)
	LOC110000785	Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Required for membrane traffic from the endoplasmic reticulum (ER) to the Go [...] (553 aa)
	LOC109986946	Uncharacterized protein. (564 aa)
	LOC110003289	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (593 aa)
	LOC109996690	Survival of motor neuron 1, telomeric. (284 aa)
	FAM53B	Uncharacterized protein. (446 aa)
	LOC109980617	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (789 aa)
	dclk1	Doublecortin-like kinase 1a. (722 aa)
	c9orf72	Zgc:100846. (462 aa)
	LOC110002606	Si:ch211-113g11.6; Belongs to the semaphorin family. (488 aa)
	llph	LLP homolog, long-term synaptic facilitation factor. (126 aa)
	LOC110005162	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2388 aa)
	nrn1	Neuritin 1a. (143 aa)
	LOC109983903	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (701 aa)
	ssna1	Sjogren syndrome nuclear autoantigen 1. (112 aa)
	impact	Impact RWD domain protein. (337 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (447 aa)
	LOC109975235	Sema domain-containing protein; Belongs to the semaphorin family. (465 aa)
	LOC109986856	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2207 aa)
	spag6	Sperm associated antigen 6. (507 aa)
	LOC109988217	Slit homolog 1b (Drosophila). (1474 aa)
	thsd7a	Thrombospondin, type I, domain containing 7Aa. (1583 aa)
	ENSLBEP00000037106	LAM_G_DOMAIN domain-containing protein. (156 aa)
	jade2	Jade family PHD finger 2. (688 aa)
	map2k4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
	ryk	Receptor like tyrosine kinase. (630 aa)
	gdf9	Growth differentiation factor 9. (434 aa)
	LOC109985368	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (411 aa)
	vcl	Vinculin. (1066 aa)
	LOC109996877	Rho family GTPase 2. (231 aa)
	LOC109985430	Fibronectin leucine rich transmembrane protein 1b. (702 aa)
	LOC109983070	Rho family GTPase 2. (234 aa)
	ENSLBEP00000007759	Neuritin 1-like a. (119 aa)
	spg11	SPG11 vesicle trafficking associated, spatacsin. (2367 aa)
	sema5b	Sema domain-containing protein. (1015 aa)
	flrt3	Fibronectin leucine rich transmembrane 3. (651 aa)
	ENSLBEP00000010466	Uncharacterized protein. (61 aa)
	arih2	RBR-type E3 ubiquitin transferase. (508 aa)
	ulk2	Unc-51 like autophagy activating kinase 2. (1030 aa)
	LOC109999320	Sema domain-containing protein. (1092 aa)
	ENSLBEP00000012133	Neuritin 1-like a. (195 aa)
	SRF	Serum response factor. (278 aa)
	ulk1	Unc-51 like autophagy activating kinase 1. (1019 aa)
	LOC109986709	Slit homolog 3 (Drosophila). (1430 aa)
	srf	Serum response factor b. (526 aa)
	cobl	Uncharacterized protein. (1596 aa)
	tmem108	Transmembrane protein 108. (519 aa)
	LOC110002886	Slit homolog 2 (Drosophila). (1465 aa)
	LOC110002895	Uncharacterized protein. (1207 aa)
	ENSLBEP00000017406	Si:dkey-33o22.1. (90 aa)
	sema5a	Sema domain-containing protein. (1078 aa)
	cyfip2	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LOC109990259	ENSLBEP00000033207	ENSLBEP00000022803	Amyloid beta precursor protein.	Endothelin 1.	0.464
EIF2AK4	impact	ENSLBEP00000035352	ENSLBEP00000024442	Eukaryotic translation initiation factor 2 alpha kinase 4.	Impact RWD domain protein.	0.576
ENSLBEP00000004382	LOC109986709	ENSLBEP00000004382	ENSLBEP00000014642	LRRNT domain-containing protein.	Slit homolog 3 (Drosophila).	0.597
ENSLBEP00000004382	LOC109986856	ENSLBEP00000004382	ENSLBEP00000023664	LRRNT domain-containing protein.	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.528
ENSLBEP00000004382	LOC110002886	ENSLBEP00000004382	ENSLBEP00000015647	LRRNT domain-containing protein.	Slit homolog 2 (Drosophila).	0.823
ENSLBEP00000004382	LOC110005162	ENSLBEP00000004382	ENSLBEP00000025910	LRRNT domain-containing protein.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.528
ENSLBEP00000010466	LOC109986946	ENSLBEP00000010466	ENSLBEP00000030898	Uncharacterized protein.	Uncharacterized protein.	0.560
ENSLBEP00000010466	raph1	ENSLBEP00000010466	ENSLBEP00000033748	Uncharacterized protein.	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1b.	0.560
ENSLBEP00000010466	vcl	ENSLBEP00000010466	ENSLBEP00000005597	Uncharacterized protein.	Vinculin.	0.719
FAM53B	cyfip2	ENSLBEP00000029653	ENSLBEP00000018096	Uncharacterized protein.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.485
LOC109983070	LOC109984747	ENSLBEP00000007204	ENSLBEP00000003571	Rho family GTPase 2.	Doublecortin-like kinase 1b.	0.408
LOC109983070	LOC109986856	ENSLBEP00000007204	ENSLBEP00000023664	Rho family GTPase 2.	Myosin IXAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.857
LOC109983070	LOC110005162	ENSLBEP00000007204	ENSLBEP00000025910	Rho family GTPase 2.	Myosin IXAb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.857
LOC109983070	c9orf72	ENSLBEP00000007204	ENSLBEP00000027165	Rho family GTPase 2.	Zgc:100846.	0.506
LOC109983070	cyfip1	ENSLBEP00000007204	ENSLBEP00000032588	Rho family GTPase 2.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.649
LOC109983070	cyfip2	ENSLBEP00000007204	ENSLBEP00000018096	Rho family GTPase 2.	Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family.	0.660
LOC109983070	dclk1	ENSLBEP00000007204	ENSLBEP00000027362	Rho family GTPase 2.	Doublecortin-like kinase 1a.	0.408
LOC109983354	c9orf72	ENSLBEP00000032915	ENSLBEP00000027165	Unc-51 like autophagy activating kinase 1a.	Zgc:100846.	0.937
LOC109983354	ist1	ENSLBEP00000032915	ENSLBEP00000003681	Unc-51 like autophagy activating kinase 1a.	IST1 factor associated with ESCRT-III.	0.595
LOC109983354	stk11	ENSLBEP00000032915	ENSLBEP00000000386	Unc-51 like autophagy activating kinase 1a.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.503