(78 nodes) Positive regulation of epithelial cell proliferation network (Labrus bergylta)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109978280	Prokineticin 1. (106 aa)
	il10	Interleukin 10. (187 aa)
	LOC109992014	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (556 aa)
	LOC109996964	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (513 aa)
	hlx	H2.0-like homeo box 1 (Drosophila). (358 aa)
	wnt2b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	ENSLBEP00000012261	Granulin b. (593 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	xbp1	X-box binding protein 1. (264 aa)
	prok1	Prokineticin 1. (136 aa)
	ENSLBEP00000006735	Vasoactive intestinal peptide. (195 aa)
	fgf7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
	ENSLBEP00000006085	GRANULINS domain-containing protein. (80 aa)
	ENSLBEP00000006003	GRANULINS domain-containing protein. (142 aa)
	ENSLBEP00000005272	Uncharacterized protein. (339 aa)
	mydgf	Myeloid-derived growth factor. (166 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC109975478	Cytochrome P450, family 7, subfamily B, polypeptide 1. (537 aa)
	igf2	Insulin-like growth factor 2b. (215 aa)
	LOC109981365	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (206 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	sirt6	Sirtuin 6. (351 aa)
	apela	Apelin receptor early endogenous ligand. (54 aa)
	tgfa	Transforming growth factor, alpha. (254 aa)
	LOC109985909	Zinc finger protein 703. (591 aa)
	ENSLBEP00000010472	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (320 aa)
	LOC109996245	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (297 aa)
	ENSLBEP00000008481	Uncharacterized protein. (1179 aa)
	hpn	Hepsin; Belongs to the peptidase S1 family. (427 aa)
	LOC109981436	Uncharacterized protein. (790 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	ENSLBEP00000036472	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (131 aa)
	LOC109994508	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (153 aa)
	ENSLBEP00000034439	Extracellular matrix protein 1a. (115 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (153 aa)
	LOC109985163	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (992 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	LOC110000815	Vascular endothelial growth factor Aa; Belongs to the PDGF/VEGF growth factor family. (188 aa)
	LOC109982398	Uncharacterized protein. (301 aa)
	LOC109997239	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (390 aa)
	LOC109998921	C2H2-type domain-containing protein. (587 aa)
	epgn	Epithelial mitogen homolog (mouse). (164 aa)
	LOC109983338	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	LOC109984085	Secretogranin II (chromogranin C), b. (578 aa)
	ENSLBEP00000007637	Uncharacterized protein. (450 aa)
	nkx2-5	NK2 homeobox 5. (315 aa)
	tnfaip3	Tumor necrosis factor, alpha-induced protein 3. (867 aa)
	ENSLBEP00000028772	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	LOC109988511	JunE proto-oncogene, AP-1 transcription factor subunit. (344 aa)
	LOC109998335	Vasoactive intestinal peptide. (152 aa)
	LOC110001224	ADAM metallopeptidase domain 17b. (898 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (394 aa)
	LOC109985782	Bone morphogenetic protein 16. (520 aa)
	ENSLBEP00000026279	Uncharacterized protein. (338 aa)
	LOC109989690	LRRCT domain-containing protein. (332 aa)
	nf1	Neurofibromin 1b. (2672 aa)
	agtr1	Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	map2k5	Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (449 aa)
	st8sia1	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
	ENSLBEP00000023548	Uncharacterized protein. (250 aa)
	LOC109981497	Uncharacterized protein. (290 aa)
	scg2	Uncharacterized protein. (608 aa)
	LOC109993761	Prokineticin 2. (106 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (257 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	LOC109983917	Inhibitor of DNA binding 1, HLH protein. (177 aa)
	bad	BCL2 associated agonist of cell death b. (221 aa)
	ENSLBEP00000020423	Prokineticin 1. (117 aa)
	LOC109977914	Disintegrin domain-containing protein. (453 aa)
	aggf1	Angiogenic factor with G patch and FHA domains 1. (756 aa)
	sp1	Sp1 transcription factor. (700 aa)
	LOC109981070	Uncharacterized protein. (662 aa)
	stxbp4	Syntaxin binding protein 4. (704 aa)
	rreb1	Ras responsive element binding protein 1a. (1593 aa)
	LOC109989077	ADAM metallopeptidase domain 17a. (867 aa)
	sirt1	Sirtuin 1. (681 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1274 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000005272	ENSLBEP00000010472	ENSLBEP00000005272	ENSLBEP00000010472	Uncharacterized protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.450
ENSLBEP00000005272	LOC109981070	ENSLBEP00000005272	ENSLBEP00000018998	Uncharacterized protein.	Uncharacterized protein.	0.852
ENSLBEP00000005272	LOC109988511	ENSLBEP00000005272	ENSLBEP00000028589	Uncharacterized protein.	JunE proto-oncogene, AP-1 transcription factor subunit.	0.450
ENSLBEP00000005272	rptor	ENSLBEP00000005272	ENSLBEP00000017019	Uncharacterized protein.	Regulatory associated protein of MTOR, complex 1.	0.508
ENSLBEP00000005272	sirt1	ENSLBEP00000005272	ENSLBEP00000017123	Uncharacterized protein.	Sirtuin 1.	0.544
ENSLBEP00000005272	sp1	ENSLBEP00000005272	ENSLBEP00000019659	Uncharacterized protein.	Sp1 transcription factor.	0.529
ENSLBEP00000010472	ENSLBEP00000005272	ENSLBEP00000010472	ENSLBEP00000005272	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Uncharacterized protein.	0.450
ENSLBEP00000010472	LOC109981070	ENSLBEP00000010472	ENSLBEP00000018998	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Uncharacterized protein.	0.450
ENSLBEP00000010472	LOC109981436	ENSLBEP00000010472	ENSLBEP00000007964	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Uncharacterized protein.	0.450
ENSLBEP00000010472	rreb1	ENSLBEP00000010472	ENSLBEP00000017558	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Ras responsive element binding protein 1a.	0.879
ENSLBEP00000010472	sirt1	ENSLBEP00000010472	ENSLBEP00000017123	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Sirtuin 1.	0.771
ENSLBEP00000010472	sirt6	ENSLBEP00000010472	ENSLBEP00000001638	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Sirtuin 6.	0.472
ENSLBEP00000010472	sp1	ENSLBEP00000010472	ENSLBEP00000019659	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Sp1 transcription factor.	0.968
ENSLBEP00000023548	smo	ENSLBEP00000023548	ENSLBEP00000022377	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.603
ENSLBEP00000028772	LOC109983338	ENSLBEP00000028772	ENSLBEP00000030362	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor a; Belongs to the G-protein coupled receptor 1 family.	0.840
ENSLBEP00000028772	agtr1	ENSLBEP00000028772	ENSLBEP00000025586	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family.	0.788
ENSLBEP00000028772	apela	ENSLBEP00000028772	ENSLBEP00000001369	Apelin receptor b; Belongs to the G-protein coupled receptor 1 family.	Apelin receptor early endogenous ligand.	0.937
LOC109977914	tgfa	ENSLBEP00000019707	ENSLBEP00000001187	Disintegrin domain-containing protein.	Transforming growth factor, alpha.	0.542
LOC109981070	ENSLBEP00000005272	ENSLBEP00000018998	ENSLBEP00000005272	Uncharacterized protein.	Uncharacterized protein.	0.852
LOC109981070	ENSLBEP00000010472	ENSLBEP00000018998	ENSLBEP00000010472	Uncharacterized protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.450