(42 nodes) Stress-activated MAPK cascade network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109989501	Protein kinase domain-containing protein. (505 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (569 aa)
	LOC109996927	Uncharacterized protein. (322 aa)
	LOC110006071	Daxx domain-containing protein. (746 aa)
	LOC109993502	Mitogen-activated protein kinase. (369 aa)
	gadd45a	Growth arrest and DNA-damage-inducible, alpha, a. (163 aa)
	nphs1	NPHS1 adhesion molecule, nephrin. (1187 aa)
	map3k13	Mitogen-activated protein kinase kinase kinase. (1013 aa)
	LOC109984106	Protein kinase domain-containing protein. (670 aa)
	LOC109991015	Si:dkey-175m17.7. (883 aa)
	GADD45A	Growth arrest and DNA-damage-inducible, alpha, b. (154 aa)
	LOC109979646	Uncharacterized protein. (342 aa)
	ENSLBEP00000038324	Uncharacterized protein. (378 aa)
	LOC109987300	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily. (426 aa)
	mapk11	Mitogen-activated protein kinase. (361 aa)
	map2k4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (432 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (602 aa)
	LOC110003529	Death-domain associated protein. (755 aa)
	ENSLBEP00000002780	Uncharacterized protein. (87 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2422 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (941 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (982 aa)
	LOC109986980	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	MAPK8IP1	Mitogen-activated protein kinase 8 interacting protein 1. (803 aa)
	pbk	PDZ binding kinase. (322 aa)
	LOC109990779	Mitogen-activated protein kinase. (476 aa)
	cdc42ep5	CDC42 effector protein (Rho GTPase binding) 5. (297 aa)
	card9	CARD domain-containing protein. (470 aa)
	map3k20	Uncharacterized protein. (803 aa)
	LOC109992271	Mitogen-activated protein kinase. (381 aa)
	ENSLBEP00000019973	NACHT domain-containing protein. (1428 aa)
	LOC109994795	Mitogen-activated protein kinase. (360 aa)
	LOC109990744	Mitogen-activated protein kinase. (381 aa)
	mapk8ip2	Mitogen-activated protein kinase 8 interacting protein 2. (1218 aa)
	ercc6	Excision repair cross-complementation group 6. (1440 aa)
	LOC109985578	Mitogen-activated protein kinase. (363 aa)
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (384 aa)
	LOC109984231	Mitogen-activated protein kinase. (361 aa)
	dusp10	Dual specificity phosphatase 10. (469 aa)
	LOC109980997	MAPK activated protein kinase 2b; Belongs to the protein kinase superfamily. (389 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (423 aa)
	LOC109981499	Mitogen-activated protein kinase. (364 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000002780	ENSLBEP00000019973	ENSLBEP00000002780	ENSLBEP00000019973	Uncharacterized protein.	NACHT domain-containing protein.	0.585
ENSLBEP00000002780	ENSLBEP00000038324	ENSLBEP00000002780	ENSLBEP00000038324	Uncharacterized protein.	Uncharacterized protein.	0.860
ENSLBEP00000002780	LOC109981499	ENSLBEP00000002780	ENSLBEP00000012339	Uncharacterized protein.	Mitogen-activated protein kinase.	0.642
ENSLBEP00000002780	LOC109984231	ENSLBEP00000002780	ENSLBEP00000014013	Uncharacterized protein.	Mitogen-activated protein kinase.	0.642
ENSLBEP00000002780	LOC109985578	ENSLBEP00000002780	ENSLBEP00000018109	Uncharacterized protein.	Mitogen-activated protein kinase.	0.642
ENSLBEP00000002780	LOC109987300	ENSLBEP00000002780	ENSLBEP00000037329	Uncharacterized protein.	Mitogen-activated protein kinase kinase 4b; Belongs to the protein kinase superfamily.	0.860
ENSLBEP00000002780	LOC109990744	ENSLBEP00000002780	ENSLBEP00000019657	Uncharacterized protein.	Mitogen-activated protein kinase.	0.794
ENSLBEP00000002780	LOC109990779	ENSLBEP00000002780	ENSLBEP00000022269	Uncharacterized protein.	Mitogen-activated protein kinase.	0.794
ENSLBEP00000002780	LOC109992271	ENSLBEP00000002780	ENSLBEP00000000204	Uncharacterized protein.	Mitogen-activated protein kinase.	0.794
ENSLBEP00000002780	LOC109993502	ENSLBEP00000002780	ENSLBEP00000008823	Uncharacterized protein.	Mitogen-activated protein kinase.	0.900
ENSLBEP00000002780	LOC109994795	ENSLBEP00000002780	ENSLBEP00000019872	Uncharacterized protein.	Mitogen-activated protein kinase.	0.642
ENSLBEP00000002780	LOC109996927	ENSLBEP00000002780	ENSLBEP00000010489	Uncharacterized protein.	Uncharacterized protein.	0.583
ENSLBEP00000002780	MAPK8IP1	ENSLBEP00000002780	ENSLBEP00000025837	Uncharacterized protein.	Mitogen-activated protein kinase 8 interacting protein 1.	0.629
ENSLBEP00000002780	card9	ENSLBEP00000002780	ENSLBEP00000021767	Uncharacterized protein.	CARD domain-containing protein.	0.558
ENSLBEP00000002780	map2k4	ENSLBEP00000002780	ENSLBEP00000036789	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.981
ENSLBEP00000002780	map2k7	ENSLBEP00000002780	ENSLBEP00000012449	Uncharacterized protein.	Mitogen-activated protein kinase kinase 7.	0.945
ENSLBEP00000002780	mapk11	ENSLBEP00000002780	ENSLBEP00000037248	Uncharacterized protein.	Mitogen-activated protein kinase.	0.642
ENSLBEP00000002780	mapk8ip2	ENSLBEP00000002780	ENSLBEP00000019411	Uncharacterized protein.	Mitogen-activated protein kinase 8 interacting protein 2.	0.629
ENSLBEP00000002780	nod1	ENSLBEP00000002780	ENSLBEP00000029926	Uncharacterized protein.	Nucleotide-binding oligomerization domain containing 1.	0.585
ENSLBEP00000002780	nod2	ENSLBEP00000002780	ENSLBEP00000030762	Uncharacterized protein.	Nucleotide-binding oligomerization domain containing 2.	0.585