(51 nodes) Misfolded protein binding network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	derl1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (250 aa)
	LOC109994268	Clusterin; Belongs to the clusterin family. (463 aa)
	LOC109976588	Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
	ENSLBEP00000038778	Uncharacterized protein. (387 aa)
	ENSLBEP00000038776	Uncharacterized protein. (128 aa)
	hspa14	Heat shock protein 14; Belongs to the heat shock protein 70 family. (505 aa)
	LOC109980701	DnaJ (Hsp40) homolog, subfamily C, member 3b. (504 aa)
	sdf2	Stromal cell-derived factor 2. (226 aa)
	ENSLBEP00000036456	Uncharacterized protein; Belongs to the heat shock protein 70 family. (617 aa)
	LOC110002809	Uncharacterized protein; Belongs to the heat shock protein 70 family. (654 aa)
	LOC110002808	Uncharacterized protein; Belongs to the heat shock protein 70 family. (653 aa)
	hspa9	Heat shock protein 9; Belongs to the heat shock protein 70 family. (672 aa)
	ENSLBEP00000027932	Uncharacterized protein. (342 aa)
	HSPA8	Heat shock protein 8; Belongs to the heat shock protein 70 family. (651 aa)
	ENSLBEP00000026991	ANK_REP_REGION domain-containing protein. (188 aa)
	LOC109978637	DnaJ heat shock protein family (Hsp40) member B11. (318 aa)
	ENSLBEP00000025864	Si:ch211-199o1.2. (305 aa)
	LOC109988506	Derlin-2. (239 aa)
	dnajc3	DnaJ (Hsp40) homolog, subfamily C, member 3a. (504 aa)
	hspa13	Heat shock protein 70 family, member 13. (439 aa)
	ENSLBEP00000023845	J domain-containing protein. (97 aa)
	ENSLBEP00000023140	Uncharacterized protein; Belongs to the heat shock protein 70 family. (601 aa)
	LOC109992030	BCL2 associated athanogene 6. (1142 aa)
	LOC109999624	Uncharacterized protein; Belongs to the heat shock protein 70 family. (638 aa)
	edem1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (638 aa)
	ENSLBEP00000000362	Tyrosine-protein kinase. (265 aa)
	dnajb11	DnaJ heat shock protein family (Hsp40) member B11. (360 aa)
	ENSLBEP00000000381	Protein kinase domain-containing protein. (76 aa)
	ENSLBEP00000000610	Uncharacterized protein; Belongs to the heat shock protein 70 family. (635 aa)
	ENSLBEP00000000720	Uncharacterized protein; Belongs to the heat shock protein 70 family. (655 aa)
	sdf2l1	Stromal cell-derived factor 2-like 1. (253 aa)
	LOC109976776	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	LOC109975544	Heat shock protein 5; Belongs to the heat shock protein 70 family. (654 aa)
	ENSLBEP00000005736	Uncharacterized protein; Belongs to the heat shock protein 70 family. (642 aa)
	LOC110005608	Uncharacterized protein; Belongs to the heat shock protein 70 family. (671 aa)
	LOC109996324	DnaJ heat shock protein family (Hsp40) member B9b. (231 aa)
	ENSLBEP00000007512	Uncharacterized protein. (124 aa)
	ENSLBEP00000007894	Uncharacterized protein. (463 aa)
	HSPA2	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family. (639 aa)
	LOC109992911	Uncharacterized protein; Belongs to the heat shock protein 70 family. (639 aa)
	LOC110003920	DnaJ heat shock protein family (Hsp40) member B9a. (217 aa)
	ENSLBEP00000012249	Uncharacterized protein. (490 aa)
	ENSLBEP00000013358	Heat shock cognate 70; Belongs to the heat shock protein 70 family. (628 aa)
	ENSLBEP00000013502	Ubiquitin-like domain-containing protein. (149 aa)
	ENSLBEP00000014437	Uncharacterized protein. (165 aa)
	dnajc10	DnaJ (Hsp40) homolog, subfamily C, member 10. (831 aa)
	bag6	BCL2 associated athanogene 6, like. (1138 aa)
	LOC109985036	Clusterin; Belongs to the clusterin family. (464 aa)
	LOC109985019	Tyrosine-protein kinase. (547 aa)
	clu	Clusterin; Belongs to the clusterin family. (505 aa)
	YES1	Tyrosine-protein kinase. (534 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000000610	ENSLBEP00000007894	ENSLBEP00000000610	ENSLBEP00000007894	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein.	0.619
ENSLBEP00000000610	ENSLBEP00000013358	ENSLBEP00000000610	ENSLBEP00000013358	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock cognate 70; Belongs to the heat shock protein 70 family.	0.619
ENSLBEP00000000610	ENSLBEP00000023140	ENSLBEP00000000610	ENSLBEP00000023140	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.619
ENSLBEP00000000610	ENSLBEP00000023845	ENSLBEP00000000610	ENSLBEP00000023845	Uncharacterized protein; Belongs to the heat shock protein 70 family.	J domain-containing protein.	0.699
ENSLBEP00000000610	ENSLBEP00000025864	ENSLBEP00000000610	ENSLBEP00000025864	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Si:ch211-199o1.2.	0.624
ENSLBEP00000000610	HSPA2	ENSLBEP00000000610	ENSLBEP00000007943	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein family A (Hsp70) member 2; Belongs to the heat shock protein 70 family.	0.618
ENSLBEP00000000610	HSPA8	ENSLBEP00000000610	ENSLBEP00000027365	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein 8; Belongs to the heat shock protein 70 family.	0.618
ENSLBEP00000000610	LOC109976776	ENSLBEP00000000610	ENSLBEP00000004317	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.685
ENSLBEP00000000610	LOC109978637	ENSLBEP00000000610	ENSLBEP00000026460	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ heat shock protein family (Hsp40) member B11.	0.880
ENSLBEP00000000610	LOC109980701	ENSLBEP00000000610	ENSLBEP00000038228	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ (Hsp40) homolog, subfamily C, member 3b.	0.731
ENSLBEP00000000610	LOC109988506	ENSLBEP00000000610	ENSLBEP00000025383	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Derlin-2.	0.685
ENSLBEP00000000610	LOC109992911	ENSLBEP00000000610	ENSLBEP00000008327	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.618
ENSLBEP00000000610	LOC109996324	ENSLBEP00000000610	ENSLBEP00000006013	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ heat shock protein family (Hsp40) member B9b.	0.808
ENSLBEP00000000610	LOC109999624	ENSLBEP00000000610	ENSLBEP00000030955	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Uncharacterized protein; Belongs to the heat shock protein 70 family.	0.620
ENSLBEP00000000610	LOC110003920	ENSLBEP00000000610	ENSLBEP00000010836	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ heat shock protein family (Hsp40) member B9a.	0.811
ENSLBEP00000000610	derl1	ENSLBEP00000000610	ENSLBEP00000007466	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.791
ENSLBEP00000000610	dnajb11	ENSLBEP00000000610	ENSLBEP00000028646	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ heat shock protein family (Hsp40) member B11.	0.902
ENSLBEP00000000610	dnajc10	ENSLBEP00000000610	ENSLBEP00000016054	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ (Hsp40) homolog, subfamily C, member 10.	0.952
ENSLBEP00000000610	dnajc3	ENSLBEP00000000610	ENSLBEP00000025219	Uncharacterized protein; Belongs to the heat shock protein 70 family.	DnaJ (Hsp40) homolog, subfamily C, member 3a.	0.751
ENSLBEP00000000610	hspa13	ENSLBEP00000000610	ENSLBEP00000024326	Uncharacterized protein; Belongs to the heat shock protein 70 family.	Heat shock protein 70 family, member 13.	0.681