(36 nodes) Regulation of type I interferon-mediated signaling pathway network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (732 aa)
	ENSLBEP00000038053	DC-STAMP domain containing 1. (413 aa)
	ttll12	Tubulin tyrosine ligase-like family, member 12. (637 aa)
	LOC109989015	Interferon regulatory factor 3. (465 aa)
	ENSLBEP00000032297	HD domain-containing protein. (528 aa)
	ENSLBEP00000031963	HD domain-containing protein. (529 aa)
	LOC110005387	HD domain-containing protein. (526 aa)
	fadd	Uncharacterized protein. (192 aa)
	mettl3	Methyltransferase like 3; Belongs to the MT-A70-like family. (592 aa)
	ENSLBEP00000027339	HD domain-containing protein. (160 aa)
	ENSLBEP00000026242	HD domain-containing protein. (489 aa)
	ENSLBEP00000026155	HD domain-containing protein. (174 aa)
	ENSLBEP00000025063	Mitochondrial E3 ubiquitin protein ligase 1. (335 aa)
	LOC109993147	RING-type domain-containing protein. (298 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (507 aa)
	ythdf3	YTH N(6)-methyladenosine RNA binding protein 3. (552 aa)
	ENSLBEP00000019673	HD domain-containing protein. (186 aa)
	LOC109977202	HD domain-containing protein. (479 aa)
	ENSLBEP00000018615	HD domain-containing protein. (495 aa)
	LOC110005080	Mitochondrial E3 ubiquitin protein ligase 1b. (352 aa)
	ENSLBEP00000017577	HD domain-containing protein. (565 aa)
	ENSLBEP00000014296	HD domain-containing protein. (518 aa)
	LOC109998717	LSM14A mRNA processing body assembly factor a. (431 aa)
	ENSLBEP00000011609	RING-type domain-containing protein. (316 aa)
	ENSLBEP00000010578	Protein kinase domain-containing protein. (147 aa)
	ENSLBEP00000009556	TANK-binding kinase 1. (663 aa)
	LOC109980900	HD domain-containing protein. (602 aa)
	ube2k	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (211 aa)
	LOC109990537	YTH N(6)-methyladenosine RNA binding protein 2. (646 aa)
	cav1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
	ENSLBEP00000003307	HD domain-containing protein. (592 aa)
	LOC109976756	HD domain-containing protein. (502 aa)
	ENSLBEP00000001481	HD domain-containing protein. (207 aa)
	LOC109990520	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	lsm14a	LSM14A mRNA processing body assembly factor b. (448 aa)
	adar	Adenosine deaminase RNA specific. (1348 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000009556	LOC109989015	ENSLBEP00000009556	ENSLBEP00000032984	TANK-binding kinase 1.	Interferon regulatory factor 3.	0.981
ENSLBEP00000009556	fadd	ENSLBEP00000009556	ENSLBEP00000028812	TANK-binding kinase 1.	Uncharacterized protein.	0.499
ENSLBEP00000010578	LOC109989015	ENSLBEP00000010578	ENSLBEP00000032984	Protein kinase domain-containing protein.	Interferon regulatory factor 3.	0.979
ENSLBEP00000010578	fadd	ENSLBEP00000010578	ENSLBEP00000028812	Protein kinase domain-containing protein.	Uncharacterized protein.	0.499
LOC109989015	ENSLBEP00000009556	ENSLBEP00000032984	ENSLBEP00000009556	Interferon regulatory factor 3.	TANK-binding kinase 1.	0.981
LOC109989015	ENSLBEP00000010578	ENSLBEP00000032984	ENSLBEP00000010578	Interferon regulatory factor 3.	Protein kinase domain-containing protein.	0.979
LOC109989015	fadd	ENSLBEP00000032984	ENSLBEP00000028812	Interferon regulatory factor 3.	Uncharacterized protein.	0.481
LOC109989015	ikbke	ENSLBEP00000032984	ENSLBEP00000016460	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.975
LOC109990520	pias4	ENSLBEP00000001239	ENSLBEP00000023757	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	Protein inhibitor of activated STAT, 4a.	0.543
LOC109990537	mettl3	ENSLBEP00000005314	ENSLBEP00000027657	YTH N(6)-methyladenosine RNA binding protein 2.	Methyltransferase like 3; Belongs to the MT-A70-like family.	0.592
fadd	ENSLBEP00000009556	ENSLBEP00000028812	ENSLBEP00000009556	Uncharacterized protein.	TANK-binding kinase 1.	0.499
fadd	ENSLBEP00000010578	ENSLBEP00000028812	ENSLBEP00000010578	Uncharacterized protein.	Protein kinase domain-containing protein.	0.499
fadd	LOC109989015	ENSLBEP00000028812	ENSLBEP00000032984	Uncharacterized protein.	Interferon regulatory factor 3.	0.481
fadd	ikbke	ENSLBEP00000028812	ENSLBEP00000016460	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.499
ikbke	LOC109989015	ENSLBEP00000016460	ENSLBEP00000032984	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Interferon regulatory factor 3.	0.975
ikbke	fadd	ENSLBEP00000016460	ENSLBEP00000028812	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	Uncharacterized protein.	0.499
mettl3	LOC109990537	ENSLBEP00000027657	ENSLBEP00000005314	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 2.	0.592
mettl3	ythdf3	ENSLBEP00000027657	ENSLBEP00000022142	Methyltransferase like 3; Belongs to the MT-A70-like family.	YTH N(6)-methyladenosine RNA binding protein 3.	0.590
pias4	LOC109990520	ENSLBEP00000023757	ENSLBEP00000001239	Protein inhibitor of activated STAT, 4a.	Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family.	0.543
pias4	ube2k	ENSLBEP00000023757	ENSLBEP00000005672	Protein inhibitor of activated STAT, 4a.	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family.	0.543