(105 nodes) Bone development network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLBEP00000001462	CNX domain-containing protein. (142 aa)
	ENSLBEP00000001446	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (203 aa)
	LOC109991707	Leucine rich repeat containing 17. (457 aa)
	ext2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
	evc	Uncharacterized protein. (966 aa)
	msx1	Muscle segment homeobox 1a. (278 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	ep300	E1A binding protein p300 a. (2577 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1151 aa)
	LOC109985864	FAM20C golgi associated secretory pathway kinase a. (571 aa)
	dhrs3	Dehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	LOC110004120	E1A binding protein p300 b. (2680 aa)
	LOC110002786	Gla domain-containing protein. (167 aa)
	itgb6	Integrin beta; Belongs to the integrin beta chain family. (782 aa)
	ENSLBEP00000034439	Extracellular matrix protein 1a. (115 aa)
	LOC110000320	ATPase H+ transporting accessory protein 1a. (486 aa)
	MEF2D	MADS-box domain-containing protein. (592 aa)
	LOC110001377	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	gp1bb	Glycoprotein Ib platelet subunit beta. (204 aa)
	LOC109988623	Golgi glycoprotein 1b. (1162 aa)
	LOC109985163	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (992 aa)
	LOC109996736	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	ENSLBEP00000032575	MADS-box domain-containing protein. (159 aa)
	LOC109987705	Vitamin K epoxide reductase complex, subunit 1. (165 aa)
	LOC110000840	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
	LOC109990439	Fam20C domain-containing protein. (566 aa)
	LOC109996227	ATPase H+ transporting accessory protein 1b. (449 aa)
	LOC109996231	Tyrosine-protein kinase. (439 aa)
	ift80	Intraflagellar transport 80 homolog (Chlamydomonas). (775 aa)
	nab2	NGFI-A binding protein 2 (EGR1 binding protein 2). (493 aa)
	ENSLBEP00000029576	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (343 aa)
	LOC109985155	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	bbx	BBX high mobility group box domain containing. (897 aa)
	LOC109986980	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	phospho2	Phosphatase, orphan 2. (241 aa)
	lrrk1	Leucine-rich repeat kinase 1. (1935 aa)
	LOC109982371	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	LOC109985782	Bone morphogenetic protein 16. (520 aa)
	LOC109976537	Meis homeobox 2b. (370 aa)
	LOC110001878	Cytochrome P450, family 26, subfamily b, polypeptide 1; Belongs to the cytochrome P450 family. (512 aa)
	ppib	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
	LOC110004714	Tetratricopeptide repeat domain 9. (251 aa)
	atg9a	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (822 aa)
	LOC109992067	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (405 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (888 aa)
	tsku	Tsukushi small leucine rich proteoglycan homolog (Xenopus laevis). (348 aa)
	LOC110002540	BRCT domain-containing protein. (636 aa)
	sp5	Sp5 transcription factor a. (376 aa)
	sh2b3	SH2B adaptor protein 3. (735 aa)
	ENSLBEP00000022422	Uncharacterized protein. (189 aa)
	ENSLBEP00000022416	Epiphycan. (537 aa)
	ENSLBEP00000022272	TAZ-type domain-containing protein. (362 aa)
	LOC109983933	Extracellular sulfatase. (886 aa)
	ENSLBEP00000022073	Uncharacterized protein. (225 aa)
	sulf1	Sulfatase 1. (1157 aa)
	ENSLBEP00000019863	Uncharacterized protein. (144 aa)
	LOC109998011	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (371 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (364 aa)
	LOC109985667	Uncharacterized protein. (185 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
	LOC109985568	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	trip11	Thyroid hormone receptor interactor 11. (1824 aa)
	LOC109991328	Fras1 related extracellular matrix 1a. (1970 aa)
	trim45	Tripartite motif containing 45. (603 aa)
	rab23	RAB23, member RAS oncogene family. (235 aa)
	mbtps2	Membrane-bound transcription factor peptidase, site 2. (409 aa)
	phex	Phosphate regulating endopeptidase homolog, X-linked. (745 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (582 aa)
	LOC109986206	RAP1A, member of RAS oncogene family b. (185 aa)
	srf	Serum response factor b. (526 aa)
	ENSLBEP00000014606	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (201 aa)
	ENSLBEP00000014589	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (160 aa)
	ENSLBEP00000014003	Uncharacterized protein. (118 aa)
	ABI1	Abl-interactor 1a. (574 aa)
	ENSLBEP00000013258	Uncharacterized protein. (404 aa)
	SRF	Serum response factor. (278 aa)
	ebp	EBP cholestenol delta-isomerase. (231 aa)
	bmpr2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1041 aa)
	slc38a10	Solute carrier family 38 member 10. (1119 aa)
	LOC109999905	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC109981009	Glycoprotein IX (platelet). (235 aa)
	smpd3	Sphingomyelin phosphodiesterase 3, neutral. (725 aa)
	ENSLBEP00000008410	Sulfatase domain-containing protein. (154 aa)
	lepr	Leptin receptor. (1144 aa)
	ENSLBEP00000007637	Uncharacterized protein. (450 aa)
	LOC109998617	Si:ch211-129c21.1; Belongs to the semaphorin family. (810 aa)
	LOC109995824	Uncharacterized protein. (1402 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	LOC109995771	Abl-interactor 1b. (496 aa)
	foxn3	Checkpoint suppressor 1. (485 aa)
	LOC109984812	Golgi glycoprotein 1a. (1168 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (797 aa)
	LOC110005565	Uncharacterized protein. (493 aa)
	ankrd11	Ankyrin repeat domain 11. (2723 aa)
	SRC	Tyrosine-protein kinase. (549 aa)
	GJA1	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (388 aa)
	anxa6	Annexin. (656 aa)
	LOC109999233	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (792 aa)
	chad	Chondroadherin. (363 aa)
	edar	Ectodysplasin A receptor. (510 aa)
	mcph1	Uncharacterized protein. (368 aa)
	LOC109979978	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta. (766 aa)
	ENSLBEP00000001811	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC109984042	Semaphorin 4e; Belongs to the semaphorin family. (791 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	LOC109996231	ENSLBEP00000013381	ENSLBEP00000031227	Abl-interactor 1a.	Tyrosine-protein kinase.	0.492
ABI1	SRC	ENSLBEP00000013381	ENSLBEP00000004031	Abl-interactor 1a.	Tyrosine-protein kinase.	0.492
ENSLBEP00000001446	ENSLBEP00000001462	ENSLBEP00000001446	ENSLBEP00000001462	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	CNX domain-containing protein.	0.559
ENSLBEP00000001446	LOC109996231	ENSLBEP00000001446	ENSLBEP00000031227	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Tyrosine-protein kinase.	0.640
ENSLBEP00000001446	SRC	ENSLBEP00000001446	ENSLBEP00000004031	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	Tyrosine-protein kinase.	0.640
ENSLBEP00000001462	ENSLBEP00000001446	ENSLBEP00000001462	ENSLBEP00000001446	CNX domain-containing protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.559
ENSLBEP00000001462	ENSLBEP00000029576	ENSLBEP00000001462	ENSLBEP00000029576	CNX domain-containing protein.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.594
ENSLBEP00000001462	LOC109996231	ENSLBEP00000001462	ENSLBEP00000031227	CNX domain-containing protein.	Tyrosine-protein kinase.	0.640
ENSLBEP00000001462	SRC	ENSLBEP00000001462	ENSLBEP00000004031	CNX domain-containing protein.	Tyrosine-protein kinase.	0.640
ENSLBEP00000001811	LOC109982371	ENSLBEP00000001811	ENSLBEP00000026874	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528
ENSLBEP00000001811	LOC109985155	ENSLBEP00000001811	ENSLBEP00000028869	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528
ENSLBEP00000001811	LOC109985568	ENSLBEP00000001811	ENSLBEP00000018851	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.547
ENSLBEP00000001811	LOC109996736	ENSLBEP00000001811	ENSLBEP00000032847	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528
ENSLBEP00000001811	ptpn11	ENSLBEP00000001811	ENSLBEP00000018954	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.547
ENSLBEP00000001811	ptpn6	ENSLBEP00000001811	ENSLBEP00000016152	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Protein tyrosine phosphatase non-receptor type 6.	0.547
ENSLBEP00000014003	LOC109996231	ENSLBEP00000014003	ENSLBEP00000031227	Uncharacterized protein.	Tyrosine-protein kinase.	0.492
ENSLBEP00000014003	SRC	ENSLBEP00000014003	ENSLBEP00000004031	Uncharacterized protein.	Tyrosine-protein kinase.	0.492
ENSLBEP00000014589	ENSLBEP00000014606	ENSLBEP00000014589	ENSLBEP00000014606	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family.	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family.	0.907
ENSLBEP00000014589	ppib	ENSLBEP00000014589	ENSLBEP00000026045	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.682
ENSLBEP00000014606	ENSLBEP00000014589	ENSLBEP00000014606	ENSLBEP00000014589	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family.	Serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family.	0.907