(129 nodes) Regulation of ERK1 and ERK2 cascade network (Labrus bergylta)

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Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	vrk3	VRK serine/threonine kinase 3. (484 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (450 aa)
	LOC109996736	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	APP	Amyloid beta precursor protein. (646 aa)
	ENSLBEP00000034119	Fibroblast growth factor 21; Belongs to the heparin-binding growth factors family. (198 aa)
	LOC110004107	SCY domain-containing protein. (91 aa)
	LOC109984526	Tyrosine-protein phosphatase non-receptor type. (395 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1151 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	tnip1	TNFAIP3 interacting protein 1. (694 aa)
	LOC110001459	Si:ch211-153j24.3. (390 aa)
	garem1	GRB2 associated, regulator of MAPK1. (843 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	htr2b	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled. (473 aa)
	nox4	FAD-binding FR-type domain-containing protein. (562 aa)
	cib1	Calcium and integrin binding 1 (calmyrin). (189 aa)
	apela	Apelin receptor early endogenous ligand. (54 aa)
	ENSLBEP00000001811	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
	LOC109997381	WNK lysine deficient protein kinase 2. (2293 aa)
	ENSLBEP00000002674	CARD domain-containing protein. (93 aa)
	ENSLBEP00000002730	C-C motif chemokine. (115 aa)
	LOC110000932	G_PROTEIN_RECEP_F1_2 domain-containing protein. (400 aa)
	rapgef2	Rap guanine nucleotide exchange factor (GEF) 2. (1455 aa)
	LOC109991015	Si:dkey-175m17.7. (883 aa)
	SPRY3	Sprouty RTK signaling antagonist 3. (301 aa)
	ENSLBEP00000004175	Sprouty RTK signaling antagonist 2. (376 aa)
	LOC110000409	Uncharacterized protein. (210 aa)
	ENSLBEP00000005453	ALK and LTK ligand 1. (154 aa)
	abl2	Tyrosine-protein kinase. (1213 aa)
	atf3	Activating transcription factor 3. (231 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (625 aa)
	LOC110004342	Uncharacterized protein. (136 aa)
	phb	Prohibitin. (271 aa)
	styx	Serine/threonine/tyrosine interacting protein. (202 aa)
	LOC109989319	SCY domain-containing protein. (97 aa)
	ENSLBEP00000007887	WNK lysine deficient protein kinase 2. (1761 aa)
	tnfaip8l3	Tumor necrosis factor, alpha-induced protein 8-like 3. (202 aa)
	LOC110003655	Elastin microfibril interfacer 1b. (1219 aa)
	ENSLBEP00000008609	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (402 aa)
	ccl17	SCY domain-containing protein. (98 aa)
	LOC109987769	Chemokine (C-C motif) ligand 25b. (100 aa)
	LOC109999905	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC109991202	Mothers against decapentaplegic homolog. (521 aa)
	ENSLBEP00000010472	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (320 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (569 aa)
	traf7	TNF receptor-associated factor 7. (654 aa)
	ENSLBEP00000011198	Pyrin domain-containing protein. (191 aa)
	LOC109990085	C-C motif chemokine. (119 aa)
	map2k7	Mitogen-activated protein kinase kinase 7. (423 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (266 aa)
	dusp10	Dual specificity phosphatase 10. (469 aa)
	nptn	Neuroplastin b. (394 aa)
	ENSLBEP00000013847	CARD domain-containing protein. (99 aa)
	LOC109991565	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	LOC109996964	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (513 aa)
	cd4	CD4-1 molecule. (473 aa)
	ENSLBEP00000014596	CARD domain-containing protein. (98 aa)
	LOC109992014	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (556 aa)
	LOC109998140	C-C motif chemokine. (91 aa)
	gas6	Growth arrest-specific 6. (627 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (582 aa)
	il1b	Interleukin-1. (251 aa)
	itgb1bp1	Integrin beta 1 binding protein 1. (200 aa)
	LOC110003082	Uncharacterized protein. (380 aa)
	ccn1	Cellular communication network factor 1. (374 aa)
	LOC110004274	Si:ch73-330k17.3. (221 aa)
	LOC110002470	Fibrinogen beta chain. (493 aa)
	LOC109985568	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (602 aa)
	spry1	Sprouty homolog 1, antagonist of FGF signaling (Drosophila). (365 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (364 aa)
	LOC109986582	Protein tyrosine phosphatase non-receptor type 1. (462 aa)
	ENSLBEP00000019973	NACHT domain-containing protein. (1428 aa)
	ENSLBEP00000020170	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
	ARHGAP8	Rho GTPase activating protein 8. (472 aa)
	LOC110003002	Uncharacterized protein; Belongs to the semaphorin family. (592 aa)
	ENSLBEP00000021486	CARD domain-containing protein. (103 aa)
	garem2	GRB2 associated, regulator of MAPK1-like. (710 aa)
	LOC109976314	C-C motif chemokine. (103 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (606 aa)
	card9	CARD domain-containing protein. (470 aa)
	dab2	DAB adaptor protein 2. (764 aa)
	LOC109989114	SCY domain-containing protein. (112 aa)
	flcn	Folliculin. (559 aa)
	ENSLBEP00000022120	Uncharacterized protein. (189 aa)
	LOC109990231	Uncharacterized protein. (251 aa)
	ENSLBEP00000022369	CARD domain-containing protein. (92 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	LOC109975219	Uncharacterized protein. (251 aa)
	fam83d	Family with sequence similarity 83 member D. (553 aa)
	LOC109975235	Sema domain-containing protein; Belongs to the semaphorin family. (465 aa)
	LOC109981172	Mothers against decapentaplegic homolog. (503 aa)
	spred3	Sprouty related EVH1 domain containing 3. (521 aa)
	prxl2c	Peroxiredoxin like 2C. (225 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	akap12	A kinase (PRKA) anchor protein 12b. (1472 aa)
	mfhas1	Malignant fibrous histiocytoma amplified sequence 1. (1024 aa)
	abl1	Tyrosine-protein kinase. (1132 aa)
	LOC110001197	BMP binding endothelial regulator. (651 aa)
	LOC110002606	Si:ch211-113g11.6; Belongs to the semaphorin family. (488 aa)
	LOC109985782	Bone morphogenetic protein 16. (520 aa)
	LOC109982371	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (229 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	LOC109998878	SERPIN domain-containing protein; Belongs to the serpin family. (470 aa)
	LOC109983283	ALK and LTK ligand 2a. (167 aa)
	LOC109986980	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (268 aa)
	serpinf2	SERPIN domain-containing protein; Belongs to the serpin family. (372 aa)
	LOC109988511	JunE proto-oncogene, AP-1 transcription factor subunit. (344 aa)
	LOC109985155	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	LOC109982312	Elastin microfibril interfacer 1a. (997 aa)
	ENSLBEP00000029382	DUF3496 domain-containing protein. (482 aa)
	ENSLBEP00000029399	CCDC144C domain-containing protein. (313 aa)
	LOC109987373	Fibronectin 1a. (2192 aa)
	ENSLBEP00000029731	CARD domain-containing protein. (92 aa)
	htr2a	5-hydroxytryptamine (serotonin) receptor 2A, genome duplicate a. (519 aa)
	LOC109983961	Si:ch211-184m13.4; Belongs to the G-protein coupled receptor 1 family. (342 aa)
	LOC109983967	G protein-coupled receptor 183a; Belongs to the G-protein coupled receptor 1 family. (384 aa)
	nod1	Nucleotide-binding oligomerization domain containing 1. (941 aa)
	nod2	Nucleotide-binding oligomerization domain containing 2. (982 aa)
	FGB	Fibrinogen beta chain. (451 aa)
	glipr2	GLI pathogenesis-related 2, like; Belongs to the CRISP family. (156 aa)
	LOC109987453	Tyrosine-protein phosphatase non-receptor type. (413 aa)
	spry4	Sprouty homolog 4 (Drosophila). (375 aa)
	ccn2	Cellular communication network factor 2a. (346 aa)
	LOC109984087	C-C motif chemokine. (100 aa)
	cunh3orf33	C18h3orf33 homolog (H. sapiens). (258 aa)
	LOC109998931	Mothers against decapentaplegic homolog. (563 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LOC109975219	ENSLBEP00000033207	ENSLBEP00000023316	Amyloid beta precursor protein.	Uncharacterized protein.	0.721
APP	LOC109990231	ENSLBEP00000033207	ENSLBEP00000022171	Amyloid beta precursor protein.	Uncharacterized protein.	0.721
APP	LOC109995483	ENSLBEP00000033207	ENSLBEP00000022560	Amyloid beta precursor protein.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.527
ENSLBEP00000001811	LOC109982371	ENSLBEP00000001811	ENSLBEP00000026874	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528
ENSLBEP00000001811	LOC109985155	ENSLBEP00000001811	ENSLBEP00000028869	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528
ENSLBEP00000001811	LOC109985568	ENSLBEP00000001811	ENSLBEP00000018851	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.547
ENSLBEP00000001811	LOC109996736	ENSLBEP00000001811	ENSLBEP00000032847	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.528
ENSLBEP00000001811	fgf19	ENSLBEP00000001811	ENSLBEP00000026929	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.705
ENSLBEP00000001811	ptpn11	ENSLBEP00000001811	ENSLBEP00000018954	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.547
ENSLBEP00000001811	ptpn6	ENSLBEP00000001811	ENSLBEP00000016152	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	Protein tyrosine phosphatase non-receptor type 6.	0.547
ENSLBEP00000002674	il1b	ENSLBEP00000002674	ENSLBEP00000016830	CARD domain-containing protein.	Interleukin-1.	0.733
ENSLBEP00000002730	LOC109976314	ENSLBEP00000002730	ENSLBEP00000021617	C-C motif chemokine.	C-C motif chemokine.	0.504
ENSLBEP00000002730	LOC109984087	ENSLBEP00000002730	ENSLBEP00000031756	C-C motif chemokine.	C-C motif chemokine.	0.855
ENSLBEP00000002730	LOC109987769	ENSLBEP00000002730	ENSLBEP00000008897	C-C motif chemokine.	Chemokine (C-C motif) ligand 25b.	0.504
ENSLBEP00000002730	LOC109989114	ENSLBEP00000002730	ENSLBEP00000021973	C-C motif chemokine.	SCY domain-containing protein.	0.424
ENSLBEP00000002730	LOC109989319	ENSLBEP00000002730	ENSLBEP00000007762	C-C motif chemokine.	SCY domain-containing protein.	0.555
ENSLBEP00000002730	LOC109990085	ENSLBEP00000002730	ENSLBEP00000012384	C-C motif chemokine.	C-C motif chemokine.	0.674
ENSLBEP00000002730	LOC109998140	ENSLBEP00000002730	ENSLBEP00000014987	C-C motif chemokine.	C-C motif chemokine.	0.691
ENSLBEP00000002730	LOC110004107	ENSLBEP00000002730	ENSLBEP00000035313	C-C motif chemokine.	SCY domain-containing protein.	0.463
ENSLBEP00000002730	cd4	ENSLBEP00000002730	ENSLBEP00000014534	C-C motif chemokine.	CD4-1 molecule.	0.542