(41 nodes) Neuron death network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109988105	Beta-synuclein; Belongs to the synuclein family. (118 aa)
	LOC110004142	J domain-containing protein. (197 aa)
	pigt	Phosphatidylinositol glycan anchor biosynthesis, class T. (631 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	APP	Amyloid beta precursor protein. (646 aa)
	LOC109996757	Diablo, IAP-binding mitochondrial protein a. (233 aa)
	BHLHE23	Basic helix-loop-helix family member e23. (227 aa)
	ENSLBEP00000034132	Diablo, IAP-binding mitochondrial protein a. (293 aa)
	LOC109985914	Citron rho-interacting serine/threonine kinase b. (1595 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2422 aa)
	LOC109978454	J domain-containing protein. (216 aa)
	NCSTN	Nicastrin. (701 aa)
	nfatc4	Nuclear factor of activated T cells 4. (853 aa)
	bag5	BCL2 associated athanogene 5. (504 aa)
	LOC109978926	Family with sequence similarity 162 member A. (212 aa)
	pjvk	Pejvakin. (392 aa)
	spg11	SPG11 vesicle trafficking associated, spatacsin. (2367 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (743 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	LOC109983093	Nerve growth factor receptor a (TNFR superfamily, member 16). (326 aa)
	LOC110000529	DnaJ (Hsp40) homolog, subfamily C, member 5ab. (183 aa)
	cln8	CLN8 transmembrane ER and ERGIC protein. (288 aa)
	ENSLBEP00000015326	Uncharacterized protein. (186 aa)
	atm	Non-specific serine/threonine protein kinase. (3019 aa)
	LOC109986845	DnaJ (Hsp40) homolog, subfamily C, member 5aa. (200 aa)
	lig4	DNA ligase. (827 aa)
	rapsn	Receptor-associated protein of the synapse, 43kD. (423 aa)
	LOC109983884	Citron rho-interacting serine/threonine kinase a; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1866 aa)
	dnajc5g	DnaJ (Hsp40) homolog, subfamily C, member 5 gamma a. (221 aa)
	LOC109998289	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (341 aa)
	LOC109992791	Protein FAM162B-like. (212 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (434 aa)
	ppargc1a	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (989 aa)
	nf1	Neurofibromin 1b. (2672 aa)
	LOC109985114	Activity-dependent neuroprotector homeobox b. (1061 aa)
	fadd	Uncharacterized protein. (192 aa)
	LOC110001922	Glyceraldehyde-3-phosphate dehydrogenase. (334 aa)
	tmtc4	Transmembrane O-mannosyltransferase targeting cadherins 4. (741 aa)
	rb1	Retinoblastoma 1. (899 aa)
	tnfrsf21	Tumor necrosis factor receptor superfamily, member 21. (699 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	LOC109983093	ENSLBEP00000033207	ENSLBEP00000010406	Amyloid beta precursor protein.	Nerve growth factor receptor a (TNFR superfamily, member 16).	0.766
APP	LOC110001922	ENSLBEP00000033207	ENSLBEP00000029397	Amyloid beta precursor protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.692
APP	NCSTN	ENSLBEP00000033207	ENSLBEP00000005751	Amyloid beta precursor protein.	Nicastrin.	0.930
APP	gapdh	ENSLBEP00000033207	ENSLBEP00000009110	Amyloid beta precursor protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.692
APP	tnfrsf21	ENSLBEP00000033207	ENSLBEP00000036551	Amyloid beta precursor protein.	Tumor necrosis factor receptor superfamily, member 21.	0.894
ENSLBEP00000034132	aifm1	ENSLBEP00000034132	ENSLBEP00000008435	Diablo, IAP-binding mitochondrial protein a.	Apoptosis inducing factor mitochondrion associated 1.	0.517
ENSLBEP00000034132	bax	ENSLBEP00000034132	ENSLBEP00000030990	Diablo, IAP-binding mitochondrial protein a.	BCL2 associated X, apoptosis regulator a.	0.556
ENSLBEP00000034132	casp9	ENSLBEP00000034132	ENSLBEP00000025551	Diablo, IAP-binding mitochondrial protein a.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.807
LOC109978454	ppargc1a	ENSLBEP00000005483	ENSLBEP00000025662	J domain-containing protein.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.612
LOC109978926	aifm1	ENSLBEP00000006985	ENSLBEP00000008435	Family with sequence similarity 162 member A.	Apoptosis inducing factor mitochondrion associated 1.	0.566
LOC109983093	APP	ENSLBEP00000010406	ENSLBEP00000033207	Nerve growth factor receptor a (TNFR superfamily, member 16).	Amyloid beta precursor protein.	0.766
LOC109983093	NCSTN	ENSLBEP00000010406	ENSLBEP00000005751	Nerve growth factor receptor a (TNFR superfamily, member 16).	Nicastrin.	0.621
LOC109983093	fadd	ENSLBEP00000010406	ENSLBEP00000028812	Nerve growth factor receptor a (TNFR superfamily, member 16).	Uncharacterized protein.	0.883
LOC109983093	tnfrsf21	ENSLBEP00000010406	ENSLBEP00000036551	Nerve growth factor receptor a (TNFR superfamily, member 16).	Tumor necrosis factor receptor superfamily, member 21.	0.439
LOC109986845	ppargc1a	ENSLBEP00000018745	ENSLBEP00000025662	DnaJ (Hsp40) homolog, subfamily C, member 5aa.	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.	0.612
LOC109992791	aifm1	ENSLBEP00000024519	ENSLBEP00000008435	Protein FAM162B-like.	Apoptosis inducing factor mitochondrion associated 1.	0.566
LOC109996757	aifm1	ENSLBEP00000034069	ENSLBEP00000008435	Diablo, IAP-binding mitochondrial protein a.	Apoptosis inducing factor mitochondrion associated 1.	0.517
LOC109996757	bax	ENSLBEP00000034069	ENSLBEP00000030990	Diablo, IAP-binding mitochondrial protein a.	BCL2 associated X, apoptosis regulator a.	0.556
LOC109996757	casp9	ENSLBEP00000034069	ENSLBEP00000025551	Diablo, IAP-binding mitochondrial protein a.	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.807
LOC109998289	LOC110001922	ENSLBEP00000023663	ENSLBEP00000029397	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Glyceraldehyde-3-phosphate dehydrogenase.	0.683