(93 nodes) Cellular response to toxic substance network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gpx7	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (185 aa)
	ENSLBEP00000027308	Uncharacterized protein. (311 aa)
	LOC109980608	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (190 aa)
	cat	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (519 aa)
	ENSLBEP00000027913	Catalase domain-containing protein. (283 aa)
	LOC110004941	Catalase domain-containing protein. (319 aa)
	nxn	Thioredoxin domain-containing protein. (418 aa)
	txndc17	Thioredoxin domain containing 17. (123 aa)
	LOC109975306	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (212 aa)
	SOD3	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (179 aa)
	esd	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
	LOC109981144	Myeloid-specific peroxidase. (765 aa)
	ENSLBEP00000029862	C1q domain-containing protein. (200 aa)
	LOC110004806	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (214 aa)
	sod1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (154 aa)
	ENSLBEP00000019276	Sod_Cu domain-containing protein. (202 aa)
	LOC109995997	Aldo-keto reductase family 1, member A1a (aldehyde reductase). (345 aa)
	glrx	Glutaredoxin (thioltransferase). (106 aa)
	mgst2	Microsomal glutathione S-transferase 2. (141 aa)
	akr1a1	Aldo-keto reductase family 1, member A1b (aldehyde reductase). (324 aa)
	ENSLBEP00000001710	Catalase domain-containing protein. (287 aa)
	LOC109986458	Si:ch211-175m2.5. (235 aa)
	LOC109984079	Glutathione peroxidase 4b. (180 aa)
	LOC110002279	Microsomal glutathione S-transferase 1.2. (153 aa)
	prdx5	Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (190 aa)
	fancc	FA complementation group C. (605 aa)
	LOC110002617	Dual oxidase. (1521 aa)
	srxn1	Sulfiredoxin. (139 aa)
	SELENOF	Selenoprotein F. (145 aa)
	LOC109975129	Uncharacterized protein. (240 aa)
	gpx8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
	ptges2	Prostaglandin E synthase 2-like. (196 aa)
	LOC109990231	Uncharacterized protein. (251 aa)
	LOC109991463	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (186 aa)
	LOC109975219	Uncharacterized protein. (251 aa)
	ubiad1	UbiA prenyltransferase domain containing 1. (349 aa)
	pink1	PTEN induced kinase 1. (575 aa)
	ENSLBEP00000024269	Tumor protein p53 inducible nuclear protein 1. (211 aa)
	ltc4s	Leukotriene C4 synthase. (150 aa)
	LOC110003427	Eosinophil peroxidase. (887 aa)
	prxl2c	Peroxiredoxin like 2C. (225 aa)
	TPO	Thyroid peroxidase. (709 aa)
	txnl1	Thioredoxin-like 1. (289 aa)
	LOC109989588	Peroxiredoxin 2. (197 aa)
	LOC109990098	Uncharacterized protein. (184 aa)
	ENSLBEP00000014090	Pyr_redox_dim domain-containing protein. (169 aa)
	LOC109996886	Peroxiredoxin 1. (198 aa)
	LOC109994152	Thioredoxin reductase 3. (586 aa)
	gfer	Sulfhydryl oxidase. (199 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (432 aa)
	mfsd11	Major facilitator superfamily domain containing 11. (464 aa)
	prdx3	Peroxiredoxin 3. (248 aa)
	LOC109990374	Uncharacterized protein. (446 aa)
	ptges	Prostaglandin E synthase. (147 aa)
	ENSLBEP00000032854	Uncharacterized protein. (193 aa)
	LOC109997910	Uncharacterized protein. (146 aa)
	park7	Parkinson protein 7. (249 aa)
	abcb6	ATP-binding cassette, sub-family B (MDR/TAP), member 6a. (852 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (606 aa)
	LOC109991624	Prostaglandin-endoperoxide synthase 1. (539 aa)
	GPX2	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (142 aa)
	ENSLBEP00000036664	Pyr_redox_2 domain-containing protein. (136 aa)
	ENSLBEP00000037007	Uncharacterized protein. (94 aa)
	gpx3	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (141 aa)
	PTGS1	Prostaglandin-endoperoxide synthase 1. (600 aa)
	TXNRD1	Thioredoxin reductase 1. (509 aa)
	ccs	Copper chaperone for superoxide dismutase. (307 aa)
	ENSLBEP00000037776	Uncharacterized protein. (141 aa)
	ENSLBEP00000037786	Uncharacterized protein. (93 aa)
	clic2	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (244 aa)
	LOC110001647	Uncharacterized protein. (783 aa)
	LOC109992971	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (130 aa)
	LOC109982570	Peroxiredoxin 6. (221 aa)
	LOC109994668	Selenoprotein U 1a. (207 aa)
	ENSLBEP00000009604	Uncharacterized protein. (73 aa)
	ENSLBEP00000009576	Uncharacterized protein. (160 aa)
	selenof	Selenoprotein F. (156 aa)
	nox5	NADPH oxidase, EF-hand calcium binding domain 5. (784 aa)
	LOC109978594	AhpC-TSA domain-containing protein. (282 aa)
	LOC109983622	Peroxiredoxin 4. (312 aa)
	GSTO1	Glutathione S-transferase omega 1; Belongs to the GST superfamily. (256 aa)
	LOC109994603	Peroxidasin. (1419 aa)
	LOC109982979	Microseminoprotein, beta-like; Belongs to the peptidase S1 family. (301 aa)
	mgst3	Microsomal glutathione S-transferase 3a. (179 aa)
	TXNL1	Thioredoxin like 1. (268 aa)
	ENSLBEP00000015138	Microseminoprotein, beta-like; Belongs to the peptidase S1 family. (291 aa)
	PRDX6	Peroxiredoxin 6. (224 aa)
	LOC109996536	C1q domain-containing protein. (877 aa)
	LOC109996542	Uncharacterized protein. (741 aa)
	sod2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (231 aa)
	LOC109992428	Microsomal glutathione S-transferase 3b. (158 aa)
	gstk1	Glutathione S-transferase kappa. (231 aa)
	ENSLBEP00000018919	DSBA domain-containing protein. (161 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000001710	ENSLBEP00000014090	ENSLBEP00000001710	ENSLBEP00000014090	Catalase domain-containing protein.	Pyr_redox_dim domain-containing protein.	0.432
ENSLBEP00000001710	ENSLBEP00000019276	ENSLBEP00000001710	ENSLBEP00000019276	Catalase domain-containing protein.	Sod_Cu domain-containing protein.	0.841
ENSLBEP00000001710	ENSLBEP00000029862	ENSLBEP00000001710	ENSLBEP00000029862	Catalase domain-containing protein.	C1q domain-containing protein.	0.542
ENSLBEP00000001710	ENSLBEP00000036664	ENSLBEP00000001710	ENSLBEP00000036664	Catalase domain-containing protein.	Pyr_redox_2 domain-containing protein.	0.432
ENSLBEP00000001710	ENSLBEP00000037007	ENSLBEP00000001710	ENSLBEP00000037007	Catalase domain-containing protein.	Uncharacterized protein.	0.430
ENSLBEP00000001710	GPX2	ENSLBEP00000001710	ENSLBEP00000036047	Catalase domain-containing protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.430
ENSLBEP00000001710	LOC109975306	ENSLBEP00000001710	ENSLBEP00000028808	Catalase domain-containing protein.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family.	0.846
ENSLBEP00000001710	LOC109980608	ENSLBEP00000001710	ENSLBEP00000027400	Catalase domain-containing protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.430
ENSLBEP00000001710	LOC109981144	ENSLBEP00000001710	ENSLBEP00000029832	Catalase domain-containing protein.	Myeloid-specific peroxidase.	0.542
ENSLBEP00000001710	LOC109982570	ENSLBEP00000001710	ENSLBEP00000010494	Catalase domain-containing protein.	Peroxiredoxin 6.	0.712
ENSLBEP00000001710	LOC109983622	ENSLBEP00000001710	ENSLBEP00000005038	Catalase domain-containing protein.	Peroxiredoxin 4.	0.691
ENSLBEP00000001710	LOC109984079	ENSLBEP00000001710	ENSLBEP00000002529	Catalase domain-containing protein.	Glutathione peroxidase 4b.	0.514
ENSLBEP00000001710	LOC109989588	ENSLBEP00000001710	ENSLBEP00000014497	Catalase domain-containing protein.	Peroxiredoxin 2.	0.691
ENSLBEP00000001710	LOC109990098	ENSLBEP00000001710	ENSLBEP00000014267	Catalase domain-containing protein.	Uncharacterized protein.	0.430
ENSLBEP00000001710	LOC109992971	ENSLBEP00000001710	ENSLBEP00000011391	Catalase domain-containing protein.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.430
ENSLBEP00000001710	LOC109994152	ENSLBEP00000001710	ENSLBEP00000013188	Catalase domain-containing protein.	Thioredoxin reductase 3.	0.432
ENSLBEP00000001710	LOC109994603	ENSLBEP00000001710	ENSLBEP00000004622	Catalase domain-containing protein.	Peroxidasin.	0.683
ENSLBEP00000001710	LOC109996536	ENSLBEP00000001710	ENSLBEP00000017258	Catalase domain-containing protein.	C1q domain-containing protein.	0.542
ENSLBEP00000001710	LOC109996542	ENSLBEP00000001710	ENSLBEP00000017549	Catalase domain-containing protein.	Uncharacterized protein.	0.542
ENSLBEP00000001710	LOC109996886	ENSLBEP00000001710	ENSLBEP00000013686	Catalase domain-containing protein.	Peroxiredoxin 1.	0.691