(107 nodes) Response to alcohol network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC109981467	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (444 aa)
	LOC109980752	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (142 aa)
	LOC110002092	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1154 aa)
	ENSLBEP00000037526	COesterase domain-containing protein. (274 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
	crhbp	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (324 aa)
	LOC109981371	Uncharacterized protein. (362 aa)
	LOC109979512	Uncharacterized protein. (764 aa)
	rusc1	RUN and SH3 domain containing 1. (1216 aa)
	ENSLBEP00000035060	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (522 aa)
	LOC109995657	Uncharacterized protein. (354 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	LOC110000085	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	ENSLBEP00000033897	Uncharacterized protein. (99 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (573 aa)
	ENSLBEP00000033096	Uncharacterized protein. (149 aa)
	LOC109984442	Prostaglandin E receptor 4 (subtype EP4) b. (447 aa)
	LOC109982938	Homeobox domain-containing protein. (291 aa)
	LOC110000840	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (485 aa)
	ENSLBEP00000032004	GRAM domain containing 1A. (415 aa)
	LOC109985151	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (714 aa)
	tufm	Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (445 aa)
	ENSLBEP00000029050	Thromboxane A2 receptor. (340 aa)
	LOC109998896	Zgc:153993. (205 aa)
	LOC109998905	Uncharacterized protein. (204 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1093 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2425 aa)
	LOC109976574	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (625 aa)
	LOC110001890	Uncharacterized protein. (346 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (454 aa)
	LOC110003117	Phosphomevalonate kinase. (194 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
	LOC109998863	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1107 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	LOC109997145	Si:dkey-27b3.2. (293 aa)
	LOC110001857	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (954 aa)
	recql5	RecQ helicase-like 5. (430 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	xrn1	5'-3' exoribonuclease 1. (1655 aa)
	blm	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (846 aa)
	ENSLBEP00000024269	Tumor protein p53 inducible nuclear protein 1. (211 aa)
	gramd1c	GRAM domain containing 1c. (532 aa)
	LOC109996097	Prostaglandin F receptor (FP); Belongs to the G-protein coupled receptor 1 family. (367 aa)
	LOC109981632	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	ENSLBEP00000023018	DNA (cytosine-5-)-methyltransferase 3 alpha a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (777 aa)
	LOC109985061	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (825 aa)
	ENSLBEP00000022374	Uncharacterized protein. (194 aa)
	LOC109989114	SCY domain-containing protein. (112 aa)
	ENSLBEP00000020170	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
	ENSLBEP00000019674	Prostaglandin E receptor 2a (subtype EP2). (356 aa)
	LOC109975918	Uncharacterized protein. (210 aa)
	cd164	CD164 molecule, sialomucin. (194 aa)
	LOC109985460	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1467 aa)
	hsd3b1	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
	LOC109994225	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
	slc10a1	Solute carrier family 10 member 1. (352 aa)
	LOC109984980	Apolipoprotein D-like. (169 aa)
	LOC109985053	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (195 aa)
	LOC109994796	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1156 aa)
	LOC109984270	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (169 aa)
	LOC109994200	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	LOC109984981	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (169 aa)
	LOC109978199	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
	ENSLBEP00000016937	Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	spidr	Uncharacterized protein. (933 aa)
	ENSLBEP00000015105	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (291 aa)
	LOC109998140	C-C motif chemokine. (91 aa)
	LOC110006230	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (484 aa)
	LOC110004950	Phosphomevalonate kinase. (196 aa)
	brca1	Uncharacterized protein. (1180 aa)
	LOC109977538	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (169 aa)
	ENSLBEP00000006251	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (183 aa)
	ENSLBEP00000006166	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (190 aa)
	dmap1	DNA methyltransferase 1 associated protein 1. (484 aa)
	LOC109988848	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
	hsd3b7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (360 aa)
	LOC110005600	Uncharacterized protein. (161 aa)
	LOC109995768	Uncharacterized protein. (748 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1509 aa)
	LOC109987702	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	GLRA3	Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (454 aa)
	LOC110000928	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (592 aa)
	LOC110000932	G_PROTEIN_RECEP_F1_2 domain-containing protein. (400 aa)
	LOC109981389	Orthodenticle homeobox 2b. (290 aa)
	ENSLBEP00000002295	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (137 aa)
	gramd1b	GRAM domain containing 1Bb. (681 aa)
	podn	Podocan. (584 aa)
	mlc1	Modulator of VRAC current 1. (399 aa)
	golph3	Golgi phosphoprotein 3. (260 aa)
	ENSLBEP00000013509	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (203 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	LOC109990637	Junction plakoglobin a. (705 aa)
	LOC110000507	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	ENSLBEP00000010800	PHD-type domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (585 aa)
	ogg1	8-oxoguanine DNA glycosylase. (385 aa)
	LOC109996245	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	ENSLBEP00000009639	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (314 aa)
	fosl1	FOS-like antigen 1a. (344 aa)
	LOC109982009	Fibroblast growth factor receptor. (835 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (258 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (415 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (743 aa)
	LOC109997493	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (524 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000002295	LOC109996245	ENSLBEP00000002295	ENSLBEP00000010408	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.875
ENSLBEP00000009639	ENSLBEP00000015105	ENSLBEP00000009639	ENSLBEP00000015105	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.643
ENSLBEP00000009639	LOC109985061	ENSLBEP00000009639	ENSLBEP00000022869	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.521
ENSLBEP00000009639	LOC109987702	ENSLBEP00000009639	ENSLBEP00000004288	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.642
ENSLBEP00000009639	LOC109994200	ENSLBEP00000009639	ENSLBEP00000017260	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.641
ENSLBEP00000009639	LOC109995657	ENSLBEP00000009639	ENSLBEP00000034719	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.621
ENSLBEP00000009639	LOC109998863	ENSLBEP00000009639	ENSLBEP00000026378	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.639
ENSLBEP00000009639	LOC110000085	ENSLBEP00000009639	ENSLBEP00000033969	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.521
ENSLBEP00000009639	LOC110000507	ENSLBEP00000009639	ENSLBEP00000011087	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.638
ENSLBEP00000009639	LOC110001890	ENSLBEP00000009639	ENSLBEP00000027444	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.621
ENSLBEP00000009639	LOC110002092	ENSLBEP00000009639	ENSLBEP00000038093	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.642
ENSLBEP00000010800	hsd3b1	ENSLBEP00000010800	ENSLBEP00000018222	PHD-type domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family.	0.497
ENSLBEP00000010800	hsd3b7	ENSLBEP00000010800	ENSLBEP00000005681	PHD-type domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family.	0.497
ENSLBEP00000015105	ENSLBEP00000009639	ENSLBEP00000015105	ENSLBEP00000009639	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.643
ENSLBEP00000015105	LOC109979512	ENSLBEP00000015105	ENSLBEP00000035773	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.656
ENSLBEP00000015105	LOC109985061	ENSLBEP00000015105	ENSLBEP00000022869	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.716
ENSLBEP00000015105	LOC109994200	ENSLBEP00000015105	ENSLBEP00000017260	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.683
ENSLBEP00000015105	LOC109994796	ENSLBEP00000015105	ENSLBEP00000017325	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.642
ENSLBEP00000015105	LOC109995657	ENSLBEP00000015105	ENSLBEP00000034719	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.789
ENSLBEP00000015105	LOC109998863	ENSLBEP00000015105	ENSLBEP00000026378	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.679