(89 nodes) Response to ketone network (Labrus bergylta)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSLBEP00000038766	Transforming growth factor, beta 2. (141 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	LOC109987676	Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
	LOC110000932	G_PROTEIN_RECEP_F1_2 domain-containing protein. (400 aa)
	LOC109984772	Periostin, osteoblast specific factor b. (768 aa)
	LOC109987702	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1509 aa)
	SMYD3	SET and MYND domain containing 3. (434 aa)
	ENSLBEP00000005272	Uncharacterized protein. (339 aa)
	LOC110005600	Uncharacterized protein. (161 aa)
	hsd3b7	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase; Belongs to the 3-beta-HSD family. (360 aa)
	ABHD2	Abhydrolase domain containing 2b. (438 aa)
	LOC109989447	Abhydrolase domain containing 2a. (431 aa)
	LOC110001654	NK3 homeobox 1. (191 aa)
	LOC109997493	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (524 aa)
	LOC109981436	Uncharacterized protein. (790 aa)
	tat	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (475 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (743 aa)
	LOC109985425	Transforming growth factor beta; Belongs to the TGF-beta family. (421 aa)
	fosl1	FOS-like antigen 1a. (344 aa)
	ENSLBEP00000009639	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (314 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (624 aa)
	ENSLBEP00000009978	ETS domain-containing protein. (165 aa)
	LOC109996245	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	rwdd1	RWD domain containing 1. (240 aa)
	LOC110000507	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1112 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	golph3	Golgi phosphoprotein 3. (260 aa)
	LOC110006230	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (484 aa)
	ENSLBEP00000015105	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (291 aa)
	LOC109990113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	gas6	Growth arrest-specific 6. (627 aa)
	LOC110006260	RWD domain-containing protein. (182 aa)
	LOC109994200	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1166 aa)
	LOC109984270	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (169 aa)
	LOC109994796	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1156 aa)
	TFAP4	Transcription factor AP-4. (320 aa)
	hsd3b1	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; Belongs to the 3-beta-HSD family. (374 aa)
	dcps	Decapping enzyme, scavenger. (299 aa)
	LOC109981070	Uncharacterized protein. (662 aa)
	ENSLBEP00000019674	Prostaglandin E receptor 2a (subtype EP2). (356 aa)
	LOC109991330	Uncharacterized protein. (1016 aa)
	ENSLBEP00000020170	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (338 aa)
	ENSLBEP00000020730	Growth differentiation factor 11. (133 aa)
	LOC109989114	SCY domain-containing protein. (112 aa)
	LOC110003053	Fin bud initiation factor a. (208 aa)
	tgfb2	Transforming growth factor, beta 2. (275 aa)
	LOC109995483	Transforming growth factor beta; Belongs to the TGF-beta family. (386 aa)
	LOC109985061	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1078 aa)
	LOC109981632	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (451 aa)
	LOC109996097	Prostaglandin F receptor (FP); Belongs to the G-protein coupled receptor 1 family. (367 aa)
	xrn1	5'-3' exoribonuclease 1. (1655 aa)
	P2RY6	Pyrimidinergic receptor P2Y6; Belongs to the G-protein coupled receptor 1 family. (379 aa)
	recql5	RecQ helicase-like 5. (430 aa)
	LOC110001857	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (954 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (434 aa)
	LOC109997145	Si:dkey-27b3.2. (293 aa)
	UBE3A	Ubiquitin protein ligase E3A. (789 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	LOC109998863	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1107 aa)
	tgfbi	Transforming growth factor, beta-induced. (677 aa)
	postn	Periostin, osteoblast specific factor a. (1133 aa)
	LOC109999589	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	ENSLBEP00000026765	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (180 aa)
	LOC109999587	Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (264 aa)
	LOC110001890	Uncharacterized protein. (346 aa)
	ndor1	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (591 aa)
	ENSLBEP00000029050	Thromboxane A2 receptor. (340 aa)
	LOC109990280	Growth differentiation factor 11. (278 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1085 aa)
	errfi1	ERBB receptor feedback inhibitor 1a. (450 aa)
	park7	Parkinson protein 7. (249 aa)
	LOC109984442	Prostaglandin E receptor 4 (subtype EP4) b. (447 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (573 aa)
	LOC109982581	Ubiquitin protein ligase E3A. (827 aa)
	LOC110000085	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1091 aa)
	acod1	Aconitate decarboxylase 1. (447 aa)
	LOC109995657	Uncharacterized protein. (354 aa)
	LOC110002786	Gla domain-containing protein. (167 aa)
	ENSLBEP00000035060	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (522 aa)
	ENSLBEP00000035061	Immunoresponsive gene 1, like. (482 aa)
	tfap4	Transcription factor AP-4 (activating enhancer binding protein 4). (333 aa)
	rusc1	RUN and SH3 domain containing 1. (1216 aa)
	LOC109979512	Uncharacterized protein. (764 aa)
	LOC109987481	Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (633 aa)
	bglap	Gla domain-containing protein. (81 aa)
	LOC110002092	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1154 aa)
	LOC109980752	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (142 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSLBEP00000005272	LOC109981070	ENSLBEP00000005272	ENSLBEP00000018998	Uncharacterized protein.	Uncharacterized protein.	0.852
ENSLBEP00000005272	LOC110001654	ENSLBEP00000005272	ENSLBEP00000006731	Uncharacterized protein.	NK3 homeobox 1.	0.525
ENSLBEP00000005272	UBE3A	ENSLBEP00000005272	ENSLBEP00000025631	Uncharacterized protein.	Ubiquitin protein ligase E3A.	0.433
ENSLBEP00000009639	ENSLBEP00000015105	ENSLBEP00000009639	ENSLBEP00000015105	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.643
ENSLBEP00000009639	LOC109985061	ENSLBEP00000009639	ENSLBEP00000022869	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.521
ENSLBEP00000009639	LOC109987702	ENSLBEP00000009639	ENSLBEP00000004288	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.642
ENSLBEP00000009639	LOC109994200	ENSLBEP00000009639	ENSLBEP00000017260	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.641
ENSLBEP00000009639	LOC109995657	ENSLBEP00000009639	ENSLBEP00000034719	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.621
ENSLBEP00000009639	LOC109998863	ENSLBEP00000009639	ENSLBEP00000026378	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.639
ENSLBEP00000009639	LOC110000085	ENSLBEP00000009639	ENSLBEP00000033969	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.521
ENSLBEP00000009639	LOC110000507	ENSLBEP00000009639	ENSLBEP00000011087	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.638
ENSLBEP00000009639	LOC110001890	ENSLBEP00000009639	ENSLBEP00000027444	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.621
ENSLBEP00000009639	LOC110002092	ENSLBEP00000009639	ENSLBEP00000038093	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.642
ENSLBEP00000009639	ndor1	ENSLBEP00000009639	ENSLBEP00000028203	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.407
ENSLBEP00000015105	ENSLBEP00000009639	ENSLBEP00000015105	ENSLBEP00000009639	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.643
ENSLBEP00000015105	LOC109979512	ENSLBEP00000015105	ENSLBEP00000035773	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.656
ENSLBEP00000015105	LOC109985061	ENSLBEP00000015105	ENSLBEP00000022869	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.716
ENSLBEP00000015105	LOC109994200	ENSLBEP00000015105	ENSLBEP00000017260	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.683
ENSLBEP00000015105	LOC109994796	ENSLBEP00000015105	ENSLBEP00000017325	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.642
ENSLBEP00000015105	LOC109995657	ENSLBEP00000015105	ENSLBEP00000034719	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.789