(71 nodes) Positive regulation of apoptotic signaling pathway network (Labrus bergylta)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	LOC109993502	Mitogen-activated protein kinase. (369 aa)
	PAK2	Non-specific serine/threonine protein kinase. (510 aa)
	LOC109987600	TNF superfamily member 10; Belongs to the tumor necrosis factor family. (287 aa)
	TIMP3	TIMP metallopeptidase inhibitor 3. (214 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1151 aa)
	LOC109983493	Inhibin subunit beta B. (409 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (631 aa)
	eef1e1	Eukaryotic translation elongation factor 1 epsilon 1. (173 aa)
	fbh1	F-box DNA helicase 1. (1069 aa)
	LOC109997240	RanBP-type and C3HC4-type zinc finger containing 1. (516 aa)
	bax	BCL2 associated X, apoptosis regulator a. (192 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (956 aa)
	ENSLBEP00000029731	CARD domain-containing protein. (92 aa)
	LOC109995578	Receptor-interacting serine-threonine kinase 3. (494 aa)
	LOC109995595	Uncharacterized protein. (994 aa)
	agt	Angiotensinogen; Belongs to the serpin family. (426 aa)
	fadd	Uncharacterized protein. (192 aa)
	inhba	Inhibin subunit beta Aa. (454 aa)
	tp73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (652 aa)
	nf1	Neurofibromin 1b. (2672 aa)
	ENSLBEP00000026047	G0/G1 switch 2. (100 aa)
	ENSLBEP00000026021	G0/G1 switch 2. (97 aa)
	nck1	Cytoplasmic protein. (393 aa)
	nck2	Cytoplasmic protein. (411 aa)
	LOC109999342	Protein phosphatase 2, regulatory subunit A, beta b. (685 aa)
	LOC109982254	Cathepsin H; Belongs to the peptidase C1 family. (305 aa)
	ENSLBEP00000024592	Inhibitor_I29 domain-containing protein. (125 aa)
	LOC109991426	Integral membrane protein 2Cb. (256 aa)
	LOC109983871-2	Cylindromatosis (turban tumor syndrome), b. (705 aa)
	ENSLBEP00000022369	CARD domain-containing protein. (92 aa)
	flcn	Folliculin. (559 aa)
	ENSLBEP00000021486	CARD domain-containing protein. (103 aa)
	LOC109978465	Serine/threonine-protein kinase PAK 2. (530 aa)
	bad	BCL2 associated agonist of cell death b. (221 aa)
	LOC109975131	Uncharacterized protein. (303 aa)
	faf1	Fas (TNFRSF6) associated factor 1. (674 aa)
	LOC109981103	Angiotensin II receptor, type 2; Belongs to the G-protein coupled receptor 1 family. (416 aa)
	LOC109993661	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (491 aa)
	LOC109990758	Muscle segment homeobox 3. (250 aa)
	ddit3	DNA-damage-inducible transcript 3. (311 aa)
	skil	SKI-like proto-oncogene a. (765 aa)
	ENSLBEP00000017452	TGF_BETA_2 domain-containing protein. (132 aa)
	sirt1	Sirtuin 1. (681 aa)
	INHBB	TGF_BETA_2 domain-containing protein. (390 aa)
	LOC109998157	Uncharacterized protein; Belongs to the protein kinase superfamily. (449 aa)
	LOC109995405	Uncharacterized protein. (333 aa)
	LOC109990113	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (154 aa)
	ENSLBEP00000014596	CARD domain-containing protein. (98 aa)
	ITM2C	Integral membrane protein 2C. (259 aa)
	ENSLBEP00000013847	CARD domain-containing protein. (99 aa)
	pak2	Non-specific serine/threonine protein kinase. (530 aa)
	dedd2	Death effector domain containing 2. (377 aa)
	LOC109990052	Uncharacterized protein. (678 aa)
	ENSLBEP00000011198	Pyrin domain-containing protein. (191 aa)
	styxl1	Serine/threonine/tyrosine interacting-like 1. (295 aa)
	traf7	TNF receptor-associated factor 7. (654 aa)
	LOC109983093	Nerve growth factor receptor a (TNFR superfamily, member 16). (326 aa)
	tpd52l1	Tpd52 like 1. (215 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (238 aa)
	zswim2	Zinc finger, SWIM-type containing 2. (571 aa)
	atf3	Activating transcription factor 3. (231 aa)
	LOC110001654	NK3 homeobox 1. (191 aa)
	ctsc	Cathepsin C; Belongs to the peptidase C1 family. (458 aa)
	nfatc4	Nuclear factor of activated T cells 4. (853 aa)
	LOC109981905	Uncharacterized protein. (315 aa)
	LOC109989921	Uncharacterized protein. (475 aa)
	pea15	Proliferation and apoptosis adaptor protein 15. (130 aa)
	ENSLBEP00000002674	CARD domain-containing protein. (93 aa)
	srpx	Sushi-repeat containing protein X-linked. (419 aa)
	GSDME	Gasdermin E. (531 aa)
	msx1	Muscle segment homeobox 1a. (278 aa)

Your Current Organism:

Labrus bergylta

NCBI taxonomy Id: 56723
Other names: L. bergylta, ballan wrasse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSH	agt	ENSLBEP00000008998	ENSLBEP00000028962	Cathepsin H; Belongs to the peptidase C1 family.	Angiotensinogen; Belongs to the serpin family.	0.572
CTSH	ctsc	ENSLBEP00000008998	ENSLBEP00000006137	Cathepsin H; Belongs to the peptidase C1 family.	Cathepsin C; Belongs to the peptidase C1 family.	0.768
ENSLBEP00000017452	INHBB	ENSLBEP00000017452	ENSLBEP00000016670	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.729
ENSLBEP00000017452	LOC109983493	ENSLBEP00000017452	ENSLBEP00000036032	TGF_BETA_2 domain-containing protein.	Inhibin subunit beta B.	0.649
ENSLBEP00000024592	agt	ENSLBEP00000024592	ENSLBEP00000028962	Inhibitor_I29 domain-containing protein.	Angiotensinogen; Belongs to the serpin family.	0.572
ENSLBEP00000024592	ctsc	ENSLBEP00000024592	ENSLBEP00000006137	Inhibitor_I29 domain-containing protein.	Cathepsin C; Belongs to the peptidase C1 family.	0.768
GSDME	LOC109993661	ENSLBEP00000000661	ENSLBEP00000018604	Gasdermin E.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.641
GSDME	tp63	ENSLBEP00000000661	ENSLBEP00000034076	Gasdermin E.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.423
GSDME	tp73	ENSLBEP00000000661	ENSLBEP00000026110	Gasdermin E.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.423
INHBB	ENSLBEP00000017452	ENSLBEP00000016670	ENSLBEP00000017452	TGF_BETA_2 domain-containing protein.	TGF_BETA_2 domain-containing protein.	0.729
INHBB	LOC109983493	ENSLBEP00000016670	ENSLBEP00000036032	TGF_BETA_2 domain-containing protein.	Inhibin subunit beta B.	0.846
INHBB	inhba	ENSLBEP00000016670	ENSLBEP00000027364	TGF_BETA_2 domain-containing protein.	Inhibin subunit beta Aa.	0.729
LOC109975131	LOC109987600	ENSLBEP00000020348	ENSLBEP00000037689	Uncharacterized protein.	TNF superfamily member 10; Belongs to the tumor necrosis factor family.	0.780
LOC109975131	LOC109993661	ENSLBEP00000020348	ENSLBEP00000018604	Uncharacterized protein.	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.625
LOC109975131	LOC109995578	ENSLBEP00000020348	ENSLBEP00000029624	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 3.	0.646
LOC109975131	LOC109998157	ENSLBEP00000020348	ENSLBEP00000016647	Uncharacterized protein.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.646
LOC109975131	fadd	ENSLBEP00000020348	ENSLBEP00000028812	Uncharacterized protein.	Uncharacterized protein.	0.993
LOC109975131	faf1	ENSLBEP00000020348	ENSLBEP00000019667	Uncharacterized protein.	Fas (TNFRSF6) associated factor 1.	0.954
LOC109975131	pea15	ENSLBEP00000020348	ENSLBEP00000002839	Uncharacterized protein.	Proliferation and apoptosis adaptor protein 15.	0.522
LOC109975131	ptprc	ENSLBEP00000020348	ENSLBEP00000036424	Uncharacterized protein.	Protein tyrosine phosphatase receptor type C.	0.528